Phagocytosis of Wnt inhibitor SFRP4 by late wound macrophages drives chronic Wnt activity for fibrotic skin healing

Human and murine skin wounding commonly results in fibrotic scarring, but the murine wounding model wound-induced hair neogenesis (WIHN) can frequently result in a regenerative repair response. Here, we show in single-cell RNA sequencing comparisons of semi-regenerative and fibrotic WIHN wounds, inc...

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Detalles Bibliográficos
Autores principales: Gay, Denise, Ghinatti, Giulia, Guerrero-Juarez, Christian F., Ferrer, Rubén A., Ferri, Federica, Lim, Chae Ho, Murakami, Shohei, Gault, Nathalie, Barroca, Vilma, Rombeau, Isabelle, Mauffrey, Philippe, Irbah, Lamya, Treffeisen, Elsa, Franz, Sandra, Boissonnas, Alexandre, Combadière, Christophe, Ito, Mayumi, Plikus, Maksim V., Romeo, Paul-Henri
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for the Advancement of Science 2020
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7083618/
https://www.ncbi.nlm.nih.gov/pubmed/32219160
http://dx.doi.org/10.1126/sciadv.aay3704

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