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Massively parallel microwire arrays integrated with CMOS chips for neural recording

Multi-channel electrical recordings of neural activity in the brain is an increasingly powerful method revealing new aspects of neural communication, computation, and prosthetics. However, while planar silicon-based CMOS devices in conventional electronics scale rapidly, neural interface devices hav...

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Detalles Bibliográficos
Autores principales: Obaid, Abdulmalik, Hanna, Mina-Elraheb, Wu, Yu-Wei, Kollo, Mihaly, Racz, Romeo, Angle, Matthew R., Müller, Jan, Brackbill, Nora, Wray, William, Franke, Felix, Chichilnisky, E. J., Hierlemann, Andreas, Ding, Jun B., Schaefer, Andreas T., Melosh, Nicholas A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for the Advancement of Science 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7083623/
https://www.ncbi.nlm.nih.gov/pubmed/32219158
http://dx.doi.org/10.1126/sciadv.aay2789
Descripción
Sumario:Multi-channel electrical recordings of neural activity in the brain is an increasingly powerful method revealing new aspects of neural communication, computation, and prosthetics. However, while planar silicon-based CMOS devices in conventional electronics scale rapidly, neural interface devices have not kept pace. Here, we present a new strategy to interface silicon-based chips with three-dimensional microwire arrays, providing the link between rapidly-developing electronics and high density neural interfaces. The system consists of a bundle of microwires mated to large-scale microelectrode arrays, such as camera chips. This system has excellent recording performance, demonstrated via single unit and local-field potential recordings in isolated retina and in the motor cortex or striatum of awake moving mice. The modular design enables a variety of microwire types and sizes to be integrated with different types of pixel arrays, connecting the rapid progress of commercial multiplexing, digitisation and data acquisition hardware together with a three-dimensional neural interface.