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ADAM17 Genetic Variants and the Response of TNF-α Inhibitor in Rheumatoid Arthritis Patients

PURPOSE: TNF-α is a transmembrane protein which requires cleavage by ADAM17 in order to act systemically. The activation of ADAM17 to generate soluble TNF‑α results in an increased inflammatory activity. We hypothesized that variants spanning the ADAM17 gene contribute towards the observed variation...

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Detalles Bibliográficos
Autores principales:	Kim, Hyun Jeong, Trinh, Nga Thi, Choi, Yunjeong, Kim, Woorim, Min, Kyung Hyun, Kang, Sang Oh, Kim, Joo Hee, Kim, Hyoun-Ah, Jung, Ju-Yang, Choi, In Ah, Lee, Kyung Eun
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Dove 2020
Materias:	Original Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7083627/ https://www.ncbi.nlm.nih.gov/pubmed/32214841 http://dx.doi.org/10.2147/PGPM.S235035

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