pH-Responsive Artesunate Polymer Prodrugs with Enhanced Ablation Effect on Rodent Xenograft Colon Cancer

PURPOSE: In this study, pH-sensitive poly(2-ethyl-2-oxazoline)-poly(lactic acid)-poly(β-amino ester) (PEOz-PLA-PBAE) triblock copolymers were synthesized and were conjugated with an antimalaria drug artesunate (ART), for inhibition of a colon cancer xenograft model. METHODS: The as-prepared polymer...

Descripción completa

Detalles Bibliográficos
Autores principales: Hao, Dan-Li, Xie, Ran, De, Ge-Jing, Yi, Hong, Zang, Chen, Yang, Mi-Yi, Liu, Li, Ma, Hai, Cai, Wei-Yan, Zhao, Qing-He, Sui, Feng, Chen, Yan-Jun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove 2020
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7083641/
https://www.ncbi.nlm.nih.gov/pubmed/32214810
http://dx.doi.org/10.2147/IJN.S242032

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7083641/
https://www.ncbi.nlm.nih.gov/pubmed/32214810
http://dx.doi.org/10.2147/IJN.S242032

Ejemplares similares