Cargando…
Enzymatic and metabolic regulation of lysine succinylation
Lysine succinylation (Ksucc), defined as a transfer of a succinyl group to a lysine residue of a protein, is a newly identified protein post-translational modification(1–3). This chemical modification is reversible, dynamic, and evolutionarily conserved (4) where it has been comprehensively studied...
Autores principales: | , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Chongqing Medical University
2019
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7083736/ https://www.ncbi.nlm.nih.gov/pubmed/32215286 http://dx.doi.org/10.1016/j.gendis.2019.09.011 |
_version_ | 1783508582220693504 |
---|---|
author | Sreedhar, Annapoorna Wiese, Elizabeth K. Hitosugi, Taro |
author_facet | Sreedhar, Annapoorna Wiese, Elizabeth K. Hitosugi, Taro |
author_sort | Sreedhar, Annapoorna |
collection | PubMed |
description | Lysine succinylation (Ksucc), defined as a transfer of a succinyl group to a lysine residue of a protein, is a newly identified protein post-translational modification(1–3). This chemical modification is reversible, dynamic, and evolutionarily conserved (4) where it has been comprehensively studied in both bacterial and mammalian cells(5–7). Numerous proteins involved in the regulation of various cellular and biological processes have been shown to be heavily succinylated(5–7). Emerging clinical data provides evidence that dysregulation of Ksucc is correlated with the development of several diseases, including cardiovascular diseases and cancer(7–9). Therefore, an in-depth understanding of Ksucc and its regulation is important not only for understanding its physiological function but also for developing drug therapies and targeted agents for these diseases. In this review, we highlight some of the recent advances in understanding the role of Ksucc and desuccinylation under physiological and pathological conditions. |
format | Online Article Text |
id | pubmed-7083736 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | Chongqing Medical University |
record_format | MEDLINE/PubMed |
spelling | pubmed-70837362020-03-25 Enzymatic and metabolic regulation of lysine succinylation Sreedhar, Annapoorna Wiese, Elizabeth K. Hitosugi, Taro Genes Dis Article Lysine succinylation (Ksucc), defined as a transfer of a succinyl group to a lysine residue of a protein, is a newly identified protein post-translational modification(1–3). This chemical modification is reversible, dynamic, and evolutionarily conserved (4) where it has been comprehensively studied in both bacterial and mammalian cells(5–7). Numerous proteins involved in the regulation of various cellular and biological processes have been shown to be heavily succinylated(5–7). Emerging clinical data provides evidence that dysregulation of Ksucc is correlated with the development of several diseases, including cardiovascular diseases and cancer(7–9). Therefore, an in-depth understanding of Ksucc and its regulation is important not only for understanding its physiological function but also for developing drug therapies and targeted agents for these diseases. In this review, we highlight some of the recent advances in understanding the role of Ksucc and desuccinylation under physiological and pathological conditions. Chongqing Medical University 2019-10-08 /pmc/articles/PMC7083736/ /pubmed/32215286 http://dx.doi.org/10.1016/j.gendis.2019.09.011 Text en © 2019 Chongqing Medical University. Production and hosting by Elsevier B.V. http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). |
spellingShingle | Article Sreedhar, Annapoorna Wiese, Elizabeth K. Hitosugi, Taro Enzymatic and metabolic regulation of lysine succinylation |
title | Enzymatic and metabolic regulation of lysine succinylation |
title_full | Enzymatic and metabolic regulation of lysine succinylation |
title_fullStr | Enzymatic and metabolic regulation of lysine succinylation |
title_full_unstemmed | Enzymatic and metabolic regulation of lysine succinylation |
title_short | Enzymatic and metabolic regulation of lysine succinylation |
title_sort | enzymatic and metabolic regulation of lysine succinylation |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7083736/ https://www.ncbi.nlm.nih.gov/pubmed/32215286 http://dx.doi.org/10.1016/j.gendis.2019.09.011 |
work_keys_str_mv | AT sreedharannapoorna enzymaticandmetabolicregulationoflysinesuccinylation AT wieseelizabethk enzymaticandmetabolicregulationoflysinesuccinylation AT hitosugitaro enzymaticandmetabolicregulationoflysinesuccinylation |