Cargando…

Pioglitazone ameliorates neuronal damage after traumatic brain injury via the PPARγ/NF-κB/IL-6 signaling pathway

Traumatic brain injury (TBI) is the major cause of high mortality and disability rates worldwide. Pioglitazone is an activator of peroxisome proliferator-activated receptor-gamma (PPARγ) that can reduce inflammation following TBI. Clinically, neuroinflammation after TBI lacks effective treatment. Al...

Descripción completa

Detalles Bibliográficos
Autores principales:	Deng, Yongbing, Jiang, Xue, Deng, Xiaoyan, Chen, Hong, Xu, Jie, Zhang, Zhaosi, Liu, Geli, Yong, Zhu, Yuan, Chengfu, Sun, Xiaochuan, Wang, Changdong
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Chongqing Medical University 2019
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7083749/ https://www.ncbi.nlm.nih.gov/pubmed/32215295 http://dx.doi.org/10.1016/j.gendis.2019.05.002

Ejemplares similares

PP2 Ameliorates Renal Fibrosis by Regulating the NF-κB/COX-2 and PPARγ/UCP2 Pathway in Diabetic Mice
por: Wei, Jinying, et al.
Publicado: (2021)

The PPAR-γ agonist pioglitazone modulates inflammation and induces neuroprotection in parkinsonian monkeys
por: Swanson, Christine R, et al.
Publicado: (2011)

Avicularin ameliorates human hepatocellular carcinoma via the regulation of NF-κB/COX-2/PPAR-γ activities
por: Wang, Zhimin, et al.
Publicado: (2019)

Yarrow oil ameliorates ulcerative colitis in mice model via regulating the NF‐κB and PPAR-γ pathways
por: Mohamed, Maged E., et al.
Publicado: (2021)

Deuterium‐Stabilized (R)‐Pioglitazone (PXL065) Is Responsible for Pioglitazone Efficacy in NASH yet Exhibits Little to No PPARγ Activity
por: Jacques, Vincent, et al.
Publicado: (2021)

IFT80 Improves Invasion Ability in Gastric Cancer Cell Line via ift80/p75NGFR/MMP9 Signaling
por: Wang, Rui, et al.
Publicado: (2018)

Effects of Pioglitazone Mediated Activation of PPAR-γ on CIDEC and Obesity Related Changes in Mice
por: Shamsi, Bilal Haider, et al.
Publicado: (2014)

Diet Modifies Pioglitazone's Influence on Hepatic PPARγ-Regulated Mitochondrial Gene Expression
por: Kulkarni, Sakil, et al.
Publicado: (2020)

Pioglitazone Ameliorates Renal Ischemia-Reperfusion Injury via Inhibition of NF-κB Activation and Inflammation in Rats
por: Zou, Gaode, et al.
Publicado: (2021)

Different skeletal effects of the peroxisome proliferator activated receptor (PPAR)α agonist fenofibrate and the PPARγ agonist pioglitazone
por: Syversen, Unni, et al.
Publicado: (2009)

Pseudolaric acid B ameliorates synovial inflammation and vessel formation by stabilizing PPARγ to inhibit NF‐κB signalling pathway
por: Lu, Jiansen, et al.
Publicado: (2021)

Structures of PPARγ complexed with lobeglitazone and pioglitazone reveal key determinants for the recognition of antidiabetic drugs
por: Lee, Min A, et al.
Publicado: (2017)

Carvacrol and PPARγ agonist, pioglitazone, affects inhaled paraquat-induced lung injury in rats
por: Amin, Fatemeh, et al.
Publicado: (2021)

Alteration of PPAR‐GAMMA (PPARG; PPARγ) and PTEN gene expression in acute myeloid leukemia patients and the promising anticancer effects of PPARγ stimulation using pioglitazone on AML cells
por: Esmaeili, Shadi, et al.
Publicado: (2021)

β-Sitosterol Protects against Myocardial Ischemia/Reperfusion Injury via Targeting PPARγ/NF-κB Signalling
por: Lin, Fengxia, et al.
Publicado: (2020)

1,8-Cineole Ameliorates LPS-Induced Vascular Endothelium Dysfunction in Mice via PPAR-γ Dependent Regulation of NF-κB
por: Linghu, Ke-Gang, et al.
Publicado: (2019)

Diacerein ameliorates acetaminophen hepatotoxicity in rats via inhibiting HMGB1/TLR4/NF-κB and upregulating PPAR-γ signal
por: Mohamed Kamel, Gellan Alaa, et al.
Publicado: (2022)

Bexarotene Exerts Protective Effects Through Modulation of the Cerebral Vascular Smooth Muscle Cell Phenotypic Transformation by Regulating PPARγ/FLAP/LTB(4) After Subarachnoid Hemorrhage in Rats
por: Zhang, Zhaosi, et al.
Publicado: (2019)

Gentiopicroside ameliorates CCl(4)-induced liver injury in mice by regulating the PPAR-γ/Nrf2 and NF-κB/IκB signaling pathways
por: Zhang, Yun, et al.
Publicado: (2023)

Prophylactic and Ameliorative Effects of PPAR-γ Agonist Pioglitazone in Improving Oxidative Stress, Germ Cell Apoptosis and Inflammation in Gentamycin-Induced Testicular Damage in Adult Male Albino Rats
por: El-Sayed, Karima, et al.
Publicado: (2022)

5-Lipoxygenase inhibition reduces inflammation and neuronal apoptosis via AKT signaling after subarachnoid hemorrhage in rats
por: Liu, Liu, et al.
Publicado: (2021)

Selected Extracts of Chinese Herbal Medicines: Their Effect on NF-κB, PPARα and PPARγ and the Respective Bioactive Compounds
por: Rozema, E., et al.
Publicado: (2012)

Roles of PPARγ/NF-κB Signaling Pathway in the Pathogenesis of Intrahepatic Cholestasis of Pregnancy
por: Zhang, Yan, et al.
Publicado: (2014)

PAK1 modulates a PPARγ/NF-κB cascade in intestinal inflammation
por: Dammann, Kyle, et al.
Publicado: (2015)

Effects of PPARγ Agonist Pioglitazone on Redox-Sensitive Cellular Signaling in Young Spontaneously Hypertensive Rats
por: Dovinová, Ima, et al.
Publicado: (2013)

Evaluation of the PPAR-γ Agonist Pioglitazone in Mild Asthma: A Double-Blind Randomized Controlled Trial
por: Anderson, J. R., et al.
Publicado: (2016)

Pioglitazone, a PPAR-γ Activator, Stimulates BK(Ca) but Suppresses IK(M) in Hippocampal Neurons
por: Chen, Tsang-Shan, et al.
Publicado: (2018)

Post-treatment with the PPAR-γ agonist pioglitazone inhibits inflammation and bacterial growth during Klebsiella pneumonia
por: Ramirez-Moral, Ivan, et al.
Publicado: (2021)

Primary cilia regulate gastric cancer-induced bone loss via cilia/Wnt/β-catenin signaling pathway
por: Xu, Jie, et al.
Publicado: (2021)

PPAR γ/Nnat/NF-κB Axis Involved in Promoting Effects of Adiponectin on Preadipocyte Differentiation
por: Yang, Wenkai, et al.
Publicado: (2019)

Ischemia reperfusion-induced metastasis is resistant to PPARγ agonist pioglitazone in a murine model of colon cancer
por: Tashiro, Yoshihiko, et al.
Publicado: (2020)

Retraction Note: Carvacrol and PPARγ agonist, pioglitazone, affects inhaled paraquat-induced lung injury in rats
por: Amin, Fatemeh, et al.
Publicado: (2022)

The PPAR-γ Agonist Pioglitazone Modulates Proliferation and Migration in HUVEC, HAOSMC and Human Arteriovenous Fistula-Derived Cells
por: Ciavarella, Carmen, et al.
Publicado: (2023)

PTEN and AKT/GSK-3β/CRMP-2 signaling pathway are involved in neuronal apoptosis and axonal injury in early brain injury after SAH in rats
por: Chen, Hong, et al.
Publicado: (2020)

Pioglitazone modulates immune activation and ameliorates inflammation induced by injured renal tubular epithelial cells via PPARγ/miRNA‑124/STAT3 signaling
por: El Gazzar, Walaa Bayoumie, et al.
Publicado: (2022)

Curcumin Attenuates Asthmatic Airway Inflammation and Mucus Hypersecretion Involving a PPARγ-Dependent NF-κB Signaling Pathway In Vivo and In Vitro
por: Zhu, Tao, et al.
Publicado: (2019)

Influence of Rosiglitazone on the Expression of PPARγ, NF-κB, and TNF-α in Rat Model of Ulcerative Colitis
por: Mao, Jing-Wei, et al.
Publicado: (2012)

Trans‐repression of NFκB pathway mediated by PPARγ improves vascular endothelium insulin resistance
por: Kong, Ying, et al.
Publicado: (2018)

Saikosaponin a attenuates hyperlipidemic pancreatitis in rats via the PPAR-γ/NF-κB signaling pathway
por: Feng, Pingping, et al.
Publicado: (2020)

Pioglitazone Reduces β Amyloid Levels via Inhibition of PPARγ Phosphorylation in a Neuronal Model of Alzheimer’s Disease
por: Quan, Qiankun, et al.
Publicado: (2019)

Cannot write session to /tmp/vufind_sessions/sess_jtcikkpvubi4gs3g1tg65fif40