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Inter- and intra-reader reproducibility of shear wave elastography measurements for musculoskeletal soft tissue masses

OBJECTIVE: To determine inter- and intra-reader reproducibility of shear wave elastography measurements for musculoskeletal soft tissue masses. MATERIALS AND METHODS: In all, 64 patients with musculoskeletal soft tissue masses were scanned by two readers prior to biopsy; each taking five measurement...

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Autores principales: Nicholls, Jonathan, Alfuraih, Abdulrahman M., Hensor, Elizabeth M. A., Robinson, Philip
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Berlin Heidelberg 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7083807/
https://www.ncbi.nlm.nih.gov/pubmed/31832739
http://dx.doi.org/10.1007/s00256-019-03300-2
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author Nicholls, Jonathan
Alfuraih, Abdulrahman M.
Hensor, Elizabeth M. A.
Robinson, Philip
author_facet Nicholls, Jonathan
Alfuraih, Abdulrahman M.
Hensor, Elizabeth M. A.
Robinson, Philip
author_sort Nicholls, Jonathan
collection PubMed
description OBJECTIVE: To determine inter- and intra-reader reproducibility of shear wave elastography measurements for musculoskeletal soft tissue masses. MATERIALS AND METHODS: In all, 64 patients with musculoskeletal soft tissue masses were scanned by two readers prior to biopsy; each taking five measurements of shear wave velocity (m/s) and stiffness (kPa). A single lesion per patient was scanned in transverse and cranio-caudal planes. Depth measurements (cm) and volume (cm(3)) were recorded for each lesion, for each reader. Linear mixed modelling was performed to assess limits of agreement (LOA), inter- and intra-reader repeatability, including analyses for measured depth and volume. RESULTS: Of the 64 lesions scanned, 24 (38%) were malignant. Bland-Altman plots demonstrated negligible bias with wide LOA for all measurements. Transverse velocity was the most reliable measure—intraclass correlation (95% CI) = 0.917 (0.886, 1)—though reader 1 measures could be between 38% lower and 57% higher than reader 2 [ratio-scale bias (95% LOA) = 0.99 (0.64, 1.55)]. Repeatability coefficients indicated most disagreement resulted from poor within-reader reproducibility. LOA between readers calculated from means of five repeated measurements were narrower—transverse velocity ratio-scale bias (95% LOA) = 1.00 (0.74, 1.35). Depth affected both estimated velocity and repeatability; volume also affected repeatability. CONCLUSION: This study found poor repeatability of measurements with wide LOA due mostly to intra-reader variability. Transverse velocity was the most reliable measure; variability may be affected by lesion depth. At least five measurements should be reported with LOA to assist future comparability between shear wave elastography systems in evaluating soft tissue masses. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (10.1007/s00256-019-03300-2) contains supplementary material, which is available to authorized users.
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spelling pubmed-70838072020-03-23 Inter- and intra-reader reproducibility of shear wave elastography measurements for musculoskeletal soft tissue masses Nicholls, Jonathan Alfuraih, Abdulrahman M. Hensor, Elizabeth M. A. Robinson, Philip Skeletal Radiol Scientific Article OBJECTIVE: To determine inter- and intra-reader reproducibility of shear wave elastography measurements for musculoskeletal soft tissue masses. MATERIALS AND METHODS: In all, 64 patients with musculoskeletal soft tissue masses were scanned by two readers prior to biopsy; each taking five measurements of shear wave velocity (m/s) and stiffness (kPa). A single lesion per patient was scanned in transverse and cranio-caudal planes. Depth measurements (cm) and volume (cm(3)) were recorded for each lesion, for each reader. Linear mixed modelling was performed to assess limits of agreement (LOA), inter- and intra-reader repeatability, including analyses for measured depth and volume. RESULTS: Of the 64 lesions scanned, 24 (38%) were malignant. Bland-Altman plots demonstrated negligible bias with wide LOA for all measurements. Transverse velocity was the most reliable measure—intraclass correlation (95% CI) = 0.917 (0.886, 1)—though reader 1 measures could be between 38% lower and 57% higher than reader 2 [ratio-scale bias (95% LOA) = 0.99 (0.64, 1.55)]. Repeatability coefficients indicated most disagreement resulted from poor within-reader reproducibility. LOA between readers calculated from means of five repeated measurements were narrower—transverse velocity ratio-scale bias (95% LOA) = 1.00 (0.74, 1.35). Depth affected both estimated velocity and repeatability; volume also affected repeatability. CONCLUSION: This study found poor repeatability of measurements with wide LOA due mostly to intra-reader variability. Transverse velocity was the most reliable measure; variability may be affected by lesion depth. At least five measurements should be reported with LOA to assist future comparability between shear wave elastography systems in evaluating soft tissue masses. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (10.1007/s00256-019-03300-2) contains supplementary material, which is available to authorized users. Springer Berlin Heidelberg 2019-12-12 2020 /pmc/articles/PMC7083807/ /pubmed/31832739 http://dx.doi.org/10.1007/s00256-019-03300-2 Text en © The Author(s) 2019 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.
spellingShingle Scientific Article
Nicholls, Jonathan
Alfuraih, Abdulrahman M.
Hensor, Elizabeth M. A.
Robinson, Philip
Inter- and intra-reader reproducibility of shear wave elastography measurements for musculoskeletal soft tissue masses
title Inter- and intra-reader reproducibility of shear wave elastography measurements for musculoskeletal soft tissue masses
title_full Inter- and intra-reader reproducibility of shear wave elastography measurements for musculoskeletal soft tissue masses
title_fullStr Inter- and intra-reader reproducibility of shear wave elastography measurements for musculoskeletal soft tissue masses
title_full_unstemmed Inter- and intra-reader reproducibility of shear wave elastography measurements for musculoskeletal soft tissue masses
title_short Inter- and intra-reader reproducibility of shear wave elastography measurements for musculoskeletal soft tissue masses
title_sort inter- and intra-reader reproducibility of shear wave elastography measurements for musculoskeletal soft tissue masses
topic Scientific Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7083807/
https://www.ncbi.nlm.nih.gov/pubmed/31832739
http://dx.doi.org/10.1007/s00256-019-03300-2
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