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A Novel 2D Standard Cartesian Representation for the Human Sensorimotor Cortex

For some experimental approaches in brain imaging, the existing normalization techniques are not always sufficient. This may be the case if the anatomical shape of the region of interest varies substantially across subjects, or if one needs to compare the left and right hemisphere in the same subjec...

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Autores principales: Bruurmijn, Mark L.C.M., Schellekens, Wouter, Raemaekers, Mathijs A.H., Ramsey, Nick F.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer US 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7083812/
https://www.ncbi.nlm.nih.gov/pubmed/31797264
http://dx.doi.org/10.1007/s12021-019-09441-y
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author Bruurmijn, Mark L.C.M.
Schellekens, Wouter
Raemaekers, Mathijs A.H.
Ramsey, Nick F.
author_facet Bruurmijn, Mark L.C.M.
Schellekens, Wouter
Raemaekers, Mathijs A.H.
Ramsey, Nick F.
author_sort Bruurmijn, Mark L.C.M.
collection PubMed
description For some experimental approaches in brain imaging, the existing normalization techniques are not always sufficient. This may be the case if the anatomical shape of the region of interest varies substantially across subjects, or if one needs to compare the left and right hemisphere in the same subject. Here we propose a new standard representation, building upon existing normalization methods: Cgrid (Cartesian geometric representation with isometric dimensions). Cgrid is based on imposing a Cartesian grid over a cortical region of interest that is bounded by anatomical (atlas-based) landmarks. We applied this new representation to the sensorimotor cortex and we evaluated its performance by studying the similarity of activation patterns for hand, foot and tongue movements between subjects, and similarity between hemispheres within subjects. The Cgrid similarities were benchmarked against the similarities of activation patterns when transformed into standard MNI space using SPM, and to similarities from FreeSurfer’s surface-based normalization. For both between-subject and between-hemisphere comparisons, similarity scores in Cgrid were high, similar to those from FreeSurfer normalization and higher than similarity scores from SPM’s MNI normalization. This indicates that Cgrid allows for a straightforward way of representing and comparing sensorimotor activity patterns across subjects and between hemispheres of the same subjects.
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spelling pubmed-70838122020-03-23 A Novel 2D Standard Cartesian Representation for the Human Sensorimotor Cortex Bruurmijn, Mark L.C.M. Schellekens, Wouter Raemaekers, Mathijs A.H. Ramsey, Nick F. Neuroinformatics Original Article For some experimental approaches in brain imaging, the existing normalization techniques are not always sufficient. This may be the case if the anatomical shape of the region of interest varies substantially across subjects, or if one needs to compare the left and right hemisphere in the same subject. Here we propose a new standard representation, building upon existing normalization methods: Cgrid (Cartesian geometric representation with isometric dimensions). Cgrid is based on imposing a Cartesian grid over a cortical region of interest that is bounded by anatomical (atlas-based) landmarks. We applied this new representation to the sensorimotor cortex and we evaluated its performance by studying the similarity of activation patterns for hand, foot and tongue movements between subjects, and similarity between hemispheres within subjects. The Cgrid similarities were benchmarked against the similarities of activation patterns when transformed into standard MNI space using SPM, and to similarities from FreeSurfer’s surface-based normalization. For both between-subject and between-hemisphere comparisons, similarity scores in Cgrid were high, similar to those from FreeSurfer normalization and higher than similarity scores from SPM’s MNI normalization. This indicates that Cgrid allows for a straightforward way of representing and comparing sensorimotor activity patterns across subjects and between hemispheres of the same subjects. Springer US 2019-12-03 2020 /pmc/articles/PMC7083812/ /pubmed/31797264 http://dx.doi.org/10.1007/s12021-019-09441-y Text en © The Author(s) 2019 Open Access This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.
spellingShingle Original Article
Bruurmijn, Mark L.C.M.
Schellekens, Wouter
Raemaekers, Mathijs A.H.
Ramsey, Nick F.
A Novel 2D Standard Cartesian Representation for the Human Sensorimotor Cortex
title A Novel 2D Standard Cartesian Representation for the Human Sensorimotor Cortex
title_full A Novel 2D Standard Cartesian Representation for the Human Sensorimotor Cortex
title_fullStr A Novel 2D Standard Cartesian Representation for the Human Sensorimotor Cortex
title_full_unstemmed A Novel 2D Standard Cartesian Representation for the Human Sensorimotor Cortex
title_short A Novel 2D Standard Cartesian Representation for the Human Sensorimotor Cortex
title_sort novel 2d standard cartesian representation for the human sensorimotor cortex
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7083812/
https://www.ncbi.nlm.nih.gov/pubmed/31797264
http://dx.doi.org/10.1007/s12021-019-09441-y
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