Cargando…

OXPHOS remodeling in high-grade prostate cancer involves mtDNA mutations and increased succinate oxidation

Rewiring of energy metabolism and adaptation of mitochondria are considered to impact on prostate cancer development and progression. Here, we report on mitochondrial respiration, DNA mutations and gene expression in paired benign/malignant human prostate tissue samples. Results reveal reduced respi...

Descripción completa

Detalles Bibliográficos
Autores principales:	Schöpf, Bernd, Weissensteiner, Hansi, Schäfer, Georg, Fazzini, Federica, Charoentong, Pornpimol, Naschberger, Andreas, Rupp, Bernhard, Fendt, Liane, Bukur, Valesca, Giese, Irina, Sorn, Patrick, Sant’Anna-Silva, Ana Carolina, Iglesias-Gonzalez, Javier, Sahin, Ugur, Kronenberg, Florian, Gnaiger, Erich, Klocker, Helmut
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2020
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7083862/ https://www.ncbi.nlm.nih.gov/pubmed/32198407 http://dx.doi.org/10.1038/s41467-020-15237-5

Ejemplares similares

Analyzing Low-Level mtDNA Heteroplasmy—Pitfalls and Challenges from Bench to Benchmarking
por: Fazzini, Federica, et al.
Publicado: (2021)

Implications of Standardized Uptake Values of Oral Squamous Cell Carcinoma in PET-CT on Prognosis, Tumor Characteristics and Mitochondrial DNA Heteroplasmy
por: Latzko, Lukas, et al.
Publicado: (2021)

mtDNA-Server: next-generation sequencing data analysis of human mitochondrial DNA in the cloud
por: Weissensteiner, Hansi, et al.
Publicado: (2016)

Contamination detection in sequencing studies using the mitochondrial phylogeny
por: Weissensteiner, Hansi, et al.
Publicado: (2021)

eCOMPAGT integrates mtDNA: import, validation and export of mitochondrial DNA profiles for population genetics, tumour dynamics and genotype-phenotype association studies
por: Weißensteiner, Hansi, et al.
Publicado: (2010)

Succinate Anaplerosis Has an Onco-Driving Potential in Prostate Cancer Cells
por: Sant’Anna-Silva, Ana Carolina B., et al.
Publicado: (2021)

Profiling of Mitochondrial DNA Heteroplasmy in a Prospective Oral Squamous Cell Carcinoma Study
por: Fendt, Liane, et al.
Publicado: (2020)

TFAM’s Contributions to mtDNA Replication and OXPHOS Biogenesis Are Genetically Separable
por: Kozhukhar, Natalya, et al.
Publicado: (2022)

Plasmid-normalized quantification of relative mitochondrial DNA copy number
por: Fazzini, Federica, et al.
Publicado: (2018)

Systemic Evidence for Mitochondrial Dysfunction in Age-Related Macular Degeneration as Revealed by mtDNA Copy Number Measurements in Peripheral Blood
por: Koller, Adriana, et al.
Publicado: (2023)

Validation of Next-Generation Sequencing of Entire Mitochondrial Genomes and the Diversity of Mitochondrial DNA Mutations in Oral Squamous Cell Carcinoma
por: Kloss-Brandstätter, Anita, et al.
Publicado: (2015)

Haplogrep 3 - an interactive haplogroup classification and analysis platform
por: Schönherr, Sebastian, et al.
Publicado: (2023)

Tfam Knockdown Results in Reduction of mtDNA Copy Number, OXPHOS Deficiency and Abnormalities in Zebrafish Embryos
por: Otten, Auke B. C., et al.
Publicado: (2020)

Succinate Accumulation Is Associated with a Shift of Mitochondrial Respiratory Control and HIF-1α Upregulation in PTEN Negative Prostate Cancer Cells
por: Weber, Anja, et al.
Publicado: (2018)

From Forensics to Clinical Research: Expanding the Variant Calling Pipeline for the Precision ID mtDNA Whole Genome Panel
por: Cortes-Figueiredo, Filipe, et al.
Publicado: (2021)

eCOMPAGT – efficient Combination and Management of Phenotypes and Genotypes for Genetic Epidemiology
por: Schönherr, Sebastian, et al.
Publicado: (2009)

MtDNA diversity of Ghana: a forensic and phylogeographic view
por: Fendt, Liane, et al.
Publicado: (2012)

Cloudgene: A graphical execution platform for MapReduce programs on private and public clouds
por: Schönherr, Sebastian, et al.
Publicado: (2012)

mtDNA Heteroplasmy at the Core of Aging-Associated Heart Failure. An Integrative View of OXPHOS and Mitochondrial Life Cycle in Cardiac Mitochondrial Physiology
por: Elorza, Alvaro A., et al.
Publicado: (2021)

The colorectal cancer immune paradox revisited
por: Angelova, Mihaela, et al.
Publicado: (2015)

Mitoribosomal regulation of OXPHOS biogenesis in plants
por: Janska, Hanna, et al.
Publicado: (2014)

Proteinopathies and OXPHOS dysfunction in neurodegenerative diseases
por: Kawamata, Hibiki, et al.
Publicado: (2017)

Impaired OXPHOS Complex III in Breast Cancer
por: Owens, Kjerstin M., et al.
Publicado: (2011)

Correction: Proteinopathies and OXPHOS dysfunction in neurodegenerative diseases
por: Kawamata, Hibiki, et al.
Publicado: (2018)

Mathematical models for translational and clinical oncology
por: Gallasch, Ralf, et al.
Publicado: (2013)

SNPflow: A Lightweight Application for the Processing, Storing and Automatic Quality Checking of Genotyping Assays
por: Weissensteiner, Hansi, et al.
Publicado: (2013)

Comparative Study of Flax and Pineapple Leaf Fiber Reinforced Poly(butylene succinate): Effect of Fiber Content on Mechanical Properties
por: Amornsakchai, Taweechai, et al.
Publicado: (2023)

HaploGrep 2: mitochondrial haplogroup classification in the era of high-throughput sequencing
por: Weissensteiner, Hansi, et al.
Publicado: (2016)

Parallel Structural Evolution of Mitochondrial Ribosomes and OXPHOS Complexes
por: van der Sluis, Eli O., et al.
Publicado: (2015)

Human diseases associated with defects in assembly of OXPHOS complexes
por: Ghezzi, Daniele, et al.
Publicado: (2018)

Intrinsic OXPHOS limitations underlie cellular bioenergetics in leukemia
por: Nelson, Margaret AM, et al.
Publicado: (2021)

Targeting Mitochondrial OXPHOS and Their Regulatory Signals in Prostate Cancers
por: Chen, Chia-Lin, et al.
Publicado: (2021)

Pyruvate and uridine rescue the metabolic profile of OXPHOS dysfunction
por: Adant, Isabelle, et al.
Publicado: (2022)

Short-term succinic acid treatment mitigates cerebellar mitochondrial OXPHOS dysfunction, neurodegeneration and ataxia in a Purkinje-specific spinocerebellar ataxia type 1 (SCA1) mouse model
por: Ferro, Austin, et al.
Publicado: (2017)

An in-depth analysis of the mitochondrial phylogenetic landscape of Cambodia
por: Kloss-Brandstätter, Anita, et al.
Publicado: (2021)

TIminer: NGS data mining pipeline for cancer immunology and immunotherapy
por: Tappeiner, Elias, et al.
Publicado: (2017)

CONAN: copy number variation analysis software for genome-wide association studies
por: Forer, Lukas, et al.
Publicado: (2010)

HLA and proteasome expression body map
por: Boegel, Sebastian, et al.
Publicado: (2018)

Achieving High-Performance Green Composites from Pineapple Leaf Fiber–Poly(butylene succinate) through Both Fiber Alignment and Matrix Orientation across the Thickness
por: Duangsuwan, Sorn, et al.
Publicado: (2023)

Microscale oxygraphy reveals OXPHOS impairment in MRC mutant cells
por: Invernizzi, F., et al.
Publicado: (2012)

Cannot write session to /tmp/vufind_sessions/sess_ko59lqfr2rf8u8l7k4ei4lv6tp