2,6-Diaminopurine as a highly potent corrector of UGA nonsense mutations

Nonsense mutations cause about 10% of genetic disease cases, and no treatments are available. Nonsense mutations can be corrected by molecules with nonsense mutation readthrough activity. An extract of the mushroom Lepista inversa has recently shown high-efficiency correction of UGA and UAA nonsense...

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Detalles Bibliográficos
Autores principales: Trzaska, Carole, Amand, Séverine, Bailly, Christine, Leroy, Catherine, Marchand, Virginie, Duvernois-Berthet, Evelyne, Saliou, Jean-Michel, Benhabiles, Hana, Werkmeister, Elisabeth, Chassat, Thierry, Guilbert, Romain, Hannebique, David, Mouray, Anthony, Copin, Marie-Christine, Moreau, Pierre-Arthur, Adriaenssens, Eric, Kulozik, Andreas, Westhof, Eric, Tulasne, David, Motorin, Yuri, Rebuffat, Sylvie, Lejeune, Fabrice
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7083880/
https://www.ncbi.nlm.nih.gov/pubmed/32198346
http://dx.doi.org/10.1038/s41467-020-15140-z

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