Development of a new oral poliovirus vaccine for the eradication end game using codon deoptimization

Enormous progress has been made in global efforts to eradicate poliovirus, using live-attenuated Sabin oral poliovirus vaccine (OPV). However, as the incidence of disease due to wild poliovirus has declined, vaccine-derived poliovirus (VDPV) has emerged in areas of low-vaccine coverage. Coordinated...

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Detalles Bibliográficos
Autores principales: Konopka-Anstadt, Jennifer L., Campagnoli, Ray, Vincent, Annelet, Shaw, Jing, Wei, Ling, Wynn, Nhien T., Smithee, Shane E., Bujaki, Erika, Te Yeh, Ming, Laassri, Majid, Zagorodnyaya, Tatiana, Weiner, Amy J., Chumakov, Konstantin, Andino, Raul, Macadam, Andrew, Kew, Olen, Burns, Cara C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7083942/
https://www.ncbi.nlm.nih.gov/pubmed/32218998
http://dx.doi.org/10.1038/s41541-020-0176-7

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