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Examination of the neural basis of psychotic-like experiences in adolescence during processing of emotional faces
Contemporary theories propose that dysregulation of emotional perception is involved in the aetiology of psychosis. 298 healthy adolescents were assessed at age 14- and 19-years using fMRI while performing a facial emotion task. Psychotic-like experiences (PLEs) were assessed with the CAPE-42 questi...
Autores principales: | , , , , , , , , , , , , , , , , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Nature Publishing Group UK
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7083946/ https://www.ncbi.nlm.nih.gov/pubmed/32198484 http://dx.doi.org/10.1038/s41598-020-62026-7 |
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author | Papanastasiou, Evangelos Mouchlianitis, Elias Joyce, Dan W. McGuire, Philip Boussebaa, Celia Banaschewski, Tobias Bokde, Arun L. W. Büchel, Christian Quinlan, Erin Desrivières, Sylvane Flor, Herta Grigis, Antoine Garavan, Hugh Spechler, Philip Gowland, Penny Heinz, Andreas Ittermann, Bernd Martinot, Marie-Laure Paillère Artiges, Eric Nees, Frauke Orfanos, Dimitri Papadopoulos Paus, Tomáš Poustka, Luise Millenet, Sabina Fröhner, Juliane H. Smolka, Michael N. Walter, Henrik Whelan, Robert Schumann, Gunter Shergill, Sukhwinder S. |
author_facet | Papanastasiou, Evangelos Mouchlianitis, Elias Joyce, Dan W. McGuire, Philip Boussebaa, Celia Banaschewski, Tobias Bokde, Arun L. W. Büchel, Christian Quinlan, Erin Desrivières, Sylvane Flor, Herta Grigis, Antoine Garavan, Hugh Spechler, Philip Gowland, Penny Heinz, Andreas Ittermann, Bernd Martinot, Marie-Laure Paillère Artiges, Eric Nees, Frauke Orfanos, Dimitri Papadopoulos Paus, Tomáš Poustka, Luise Millenet, Sabina Fröhner, Juliane H. Smolka, Michael N. Walter, Henrik Whelan, Robert Schumann, Gunter Shergill, Sukhwinder S. |
author_sort | Papanastasiou, Evangelos |
collection | PubMed |
description | Contemporary theories propose that dysregulation of emotional perception is involved in the aetiology of psychosis. 298 healthy adolescents were assessed at age 14- and 19-years using fMRI while performing a facial emotion task. Psychotic-like experiences (PLEs) were assessed with the CAPE-42 questionnaire at age 19. The high PLEs group at age 19 years exhibited an enhanced response in right insular cortex and decreased response in right prefrontal, right parahippocampal and left striatal regions; also, a gradient of decreasing response to emotional faces with age, from 14 to 19 years, in the right parahippocampal region and left insular cortical area. The right insula demonstrated an increasing response to emotional faces with increasing age in the low PLEs group, and a decreasing response over time in the high PLEs group. The change in parahippocampal/amygdala and insula responses during the perception of emotional faces in adolescents with high PLEs between the ages of 14 and 19 suggests a potential ‘aberrant’ neurodevelopmental trajectory for critical limbic areas. Our findings emphasize the role of the frontal and limbic areas in the aetiology of psychotic symptoms, in subjects without the illness phenotype and the confounds introduced by antipsychotic medication. |
format | Online Article Text |
id | pubmed-7083946 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | Nature Publishing Group UK |
record_format | MEDLINE/PubMed |
spelling | pubmed-70839462020-03-26 Examination of the neural basis of psychotic-like experiences in adolescence during processing of emotional faces Papanastasiou, Evangelos Mouchlianitis, Elias Joyce, Dan W. McGuire, Philip Boussebaa, Celia Banaschewski, Tobias Bokde, Arun L. W. Büchel, Christian Quinlan, Erin Desrivières, Sylvane Flor, Herta Grigis, Antoine Garavan, Hugh Spechler, Philip Gowland, Penny Heinz, Andreas Ittermann, Bernd Martinot, Marie-Laure Paillère Artiges, Eric Nees, Frauke Orfanos, Dimitri Papadopoulos Paus, Tomáš Poustka, Luise Millenet, Sabina Fröhner, Juliane H. Smolka, Michael N. Walter, Henrik Whelan, Robert Schumann, Gunter Shergill, Sukhwinder S. Sci Rep Article Contemporary theories propose that dysregulation of emotional perception is involved in the aetiology of psychosis. 298 healthy adolescents were assessed at age 14- and 19-years using fMRI while performing a facial emotion task. Psychotic-like experiences (PLEs) were assessed with the CAPE-42 questionnaire at age 19. The high PLEs group at age 19 years exhibited an enhanced response in right insular cortex and decreased response in right prefrontal, right parahippocampal and left striatal regions; also, a gradient of decreasing response to emotional faces with age, from 14 to 19 years, in the right parahippocampal region and left insular cortical area. The right insula demonstrated an increasing response to emotional faces with increasing age in the low PLEs group, and a decreasing response over time in the high PLEs group. The change in parahippocampal/amygdala and insula responses during the perception of emotional faces in adolescents with high PLEs between the ages of 14 and 19 suggests a potential ‘aberrant’ neurodevelopmental trajectory for critical limbic areas. Our findings emphasize the role of the frontal and limbic areas in the aetiology of psychotic symptoms, in subjects without the illness phenotype and the confounds introduced by antipsychotic medication. Nature Publishing Group UK 2020-03-20 /pmc/articles/PMC7083946/ /pubmed/32198484 http://dx.doi.org/10.1038/s41598-020-62026-7 Text en © The Author(s) 2020 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/. |
spellingShingle | Article Papanastasiou, Evangelos Mouchlianitis, Elias Joyce, Dan W. McGuire, Philip Boussebaa, Celia Banaschewski, Tobias Bokde, Arun L. W. Büchel, Christian Quinlan, Erin Desrivières, Sylvane Flor, Herta Grigis, Antoine Garavan, Hugh Spechler, Philip Gowland, Penny Heinz, Andreas Ittermann, Bernd Martinot, Marie-Laure Paillère Artiges, Eric Nees, Frauke Orfanos, Dimitri Papadopoulos Paus, Tomáš Poustka, Luise Millenet, Sabina Fröhner, Juliane H. Smolka, Michael N. Walter, Henrik Whelan, Robert Schumann, Gunter Shergill, Sukhwinder S. Examination of the neural basis of psychotic-like experiences in adolescence during processing of emotional faces |
title | Examination of the neural basis of psychotic-like experiences in adolescence during processing of emotional faces |
title_full | Examination of the neural basis of psychotic-like experiences in adolescence during processing of emotional faces |
title_fullStr | Examination of the neural basis of psychotic-like experiences in adolescence during processing of emotional faces |
title_full_unstemmed | Examination of the neural basis of psychotic-like experiences in adolescence during processing of emotional faces |
title_short | Examination of the neural basis of psychotic-like experiences in adolescence during processing of emotional faces |
title_sort | examination of the neural basis of psychotic-like experiences in adolescence during processing of emotional faces |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7083946/ https://www.ncbi.nlm.nih.gov/pubmed/32198484 http://dx.doi.org/10.1038/s41598-020-62026-7 |
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