Neonatal outcome of children born after ICSI with epididymal or testicular sperm: A 10-year study in China

Some studies show that children born after ICSI with non-ejaculated sperm are at increased risk of birth defects, other studies hold the opposite view. Does neonatal outcome including congenital malformations in children born after ICSI with percutaneous epididymal sperm aspiration (PESA) and testic...

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Autores principales: Jin, Lei, Li, Zhou, Gu, Longjie, Huang, Bo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
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Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7083972/
https://www.ncbi.nlm.nih.gov/pubmed/32198466
http://dx.doi.org/10.1038/s41598-020-62102-y
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author Jin, Lei
Li, Zhou
Gu, Longjie
Huang, Bo
author_facet Jin, Lei
Li, Zhou
Gu, Longjie
Huang, Bo
author_sort Jin, Lei
collection PubMed
description Some studies show that children born after ICSI with non-ejaculated sperm are at increased risk of birth defects, other studies hold the opposite view. Does neonatal outcome including congenital malformations in children born after ICSI with percutaneous epididymal sperm aspiration (PESA) and testicular sperm aspiration (TESA) differ from neonatal outcome in children born after ICSI with ejaculated sperm? In this study, we examined the data from our IVF center from 2006 to 2016, to compare neonatal outcomes and rates of congenital malformations in children born after ICSI with different sperm origin. The results showed the clinical pregnancy rate and implantation rate of non-ejaculated sperm group were significantly higher (P < 0.001) than ejaculated sperm group. There were 775 clinical pregnancies from non-ejaculated sperm group and 2,486 clinical pregnancies from ejaculated sperm group. Most of the clinical pregnancy outcomes were comparable between non-ejaculated sperm group and ejaculated sperm group (p > 0.05): the miscarriage rate per transfer, ectopic pregnancy rate per clinical pregnancy, induced abortion rate per clinical pregnancy and fetal deaths per clinical pregnancy. However, the live delivery rate per transfer of non-ejaculated sperm group was significantly higher than that of ejaculated sperm group (45.4% vs 36.7%, P < 0.001). Moreover, the comparison between the epididymal sperm, testicular sperm and ejaculated sperm groups showed there were no difference in the incidence of congenital malformations of babies live birth. Among singleton gestation live births, there were more girls than boys in both non-ejaculated sperm and ejaculated sperm group. In conclusion, the present study clearly showed no statistical increased risk in neonatal outcomes of newborns were found in the ICSI treatment with epididymal or testicular sperm. It may provide information for consultation for ICSI treatment in PESA or TESA patients.
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spelling pubmed-70839722020-03-26 Neonatal outcome of children born after ICSI with epididymal or testicular sperm: A 10-year study in China Jin, Lei Li, Zhou Gu, Longjie Huang, Bo Sci Rep Article Some studies show that children born after ICSI with non-ejaculated sperm are at increased risk of birth defects, other studies hold the opposite view. Does neonatal outcome including congenital malformations in children born after ICSI with percutaneous epididymal sperm aspiration (PESA) and testicular sperm aspiration (TESA) differ from neonatal outcome in children born after ICSI with ejaculated sperm? In this study, we examined the data from our IVF center from 2006 to 2016, to compare neonatal outcomes and rates of congenital malformations in children born after ICSI with different sperm origin. The results showed the clinical pregnancy rate and implantation rate of non-ejaculated sperm group were significantly higher (P < 0.001) than ejaculated sperm group. There were 775 clinical pregnancies from non-ejaculated sperm group and 2,486 clinical pregnancies from ejaculated sperm group. Most of the clinical pregnancy outcomes were comparable between non-ejaculated sperm group and ejaculated sperm group (p > 0.05): the miscarriage rate per transfer, ectopic pregnancy rate per clinical pregnancy, induced abortion rate per clinical pregnancy and fetal deaths per clinical pregnancy. However, the live delivery rate per transfer of non-ejaculated sperm group was significantly higher than that of ejaculated sperm group (45.4% vs 36.7%, P < 0.001). Moreover, the comparison between the epididymal sperm, testicular sperm and ejaculated sperm groups showed there were no difference in the incidence of congenital malformations of babies live birth. Among singleton gestation live births, there were more girls than boys in both non-ejaculated sperm and ejaculated sperm group. In conclusion, the present study clearly showed no statistical increased risk in neonatal outcomes of newborns were found in the ICSI treatment with epididymal or testicular sperm. It may provide information for consultation for ICSI treatment in PESA or TESA patients. Nature Publishing Group UK 2020-03-20 /pmc/articles/PMC7083972/ /pubmed/32198466 http://dx.doi.org/10.1038/s41598-020-62102-y Text en © The Author(s) 2020 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
spellingShingle Article
Jin, Lei
Li, Zhou
Gu, Longjie
Huang, Bo
Neonatal outcome of children born after ICSI with epididymal or testicular sperm: A 10-year study in China
title Neonatal outcome of children born after ICSI with epididymal or testicular sperm: A 10-year study in China
title_full Neonatal outcome of children born after ICSI with epididymal or testicular sperm: A 10-year study in China
title_fullStr Neonatal outcome of children born after ICSI with epididymal or testicular sperm: A 10-year study in China
title_full_unstemmed Neonatal outcome of children born after ICSI with epididymal or testicular sperm: A 10-year study in China
title_short Neonatal outcome of children born after ICSI with epididymal or testicular sperm: A 10-year study in China
title_sort neonatal outcome of children born after icsi with epididymal or testicular sperm: a 10-year study in china
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7083972/
https://www.ncbi.nlm.nih.gov/pubmed/32198466
http://dx.doi.org/10.1038/s41598-020-62102-y
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AT gulongjie neonataloutcomeofchildrenbornaftericsiwithepididymalortesticularsperma10yearstudyinchina
AT huangbo neonataloutcomeofchildrenbornaftericsiwithepididymalortesticularsperma10yearstudyinchina

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