Treatment of Anti–NMDA Receptor Encephalitis with Ovarian Teratoma Removal: A Literature Review and Two Case Reports

BACKGROUND: N-methyl-d-aspartate receptor (NMDAR) antibody encephalitis appears common in the world, but the number of clinical cases in Vietnam which were recorded is rare. CASE REPORT: We describe two new cases of disease in recent years with the aim of contributing to diagnosis and treatment expe...

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Autores principales: Tu, Nguyen Phuong, Nha, Pham Ba, Hung, Nguyen Duy, Minh, Nguyen Hoang, Anh, Hoang Ngoc, Dinh, Thien Chu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Republic of Macedonia 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7084035/
https://www.ncbi.nlm.nih.gov/pubmed/32215098
http://dx.doi.org/10.3889/oamjms.2019.839
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author Tu, Nguyen Phuong
Nha, Pham Ba
Hung, Nguyen Duy
Minh, Nguyen Hoang
Anh, Hoang Ngoc
Dinh, Thien Chu
author_facet Tu, Nguyen Phuong
Nha, Pham Ba
Hung, Nguyen Duy
Minh, Nguyen Hoang
Anh, Hoang Ngoc
Dinh, Thien Chu
author_sort Tu, Nguyen Phuong
collection PubMed
description BACKGROUND: N-methyl-d-aspartate receptor (NMDAR) antibody encephalitis appears common in the world, but the number of clinical cases in Vietnam which were recorded is rare. CASE REPORT: We describe two new cases of disease in recent years with the aim of contributing to diagnosis and treatment experiences. These cases were noted over the past 3 years with the patients who have been treated at lower levels but have no results. They came to us when symptoms became worse and therefore required prolonged treatment with special intensive care facilities. The atypical and easily confused symptoms are the reasons that make the disease be detected late; leading to a much higher cost of treatment and the complication may appear in the patient. In the past, patients with these manifestations were diagnosed with unexplained encephalitis and severe sequelae or death. Autoimmune encephalitis has many types; NMDA encephalitis associated with ovarian teratoma is the most common autoimmune encephalitis in young women. CONCLUSION: In conclusion, based on the case report, we hope to contribute some experiences on the diagnosis and the strategy in early treatment. With most female patients at very young age, early treatment to avoid complications will help patients have a quality life and maintain reproductive function.
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spelling pubmed-70840352020-03-25 Treatment of Anti–NMDA Receptor Encephalitis with Ovarian Teratoma Removal: A Literature Review and Two Case Reports Tu, Nguyen Phuong Nha, Pham Ba Hung, Nguyen Duy Minh, Nguyen Hoang Anh, Hoang Ngoc Dinh, Thien Chu Open Access Maced J Med Sci Basic and Clinical Medical Researches in Vietnam BACKGROUND: N-methyl-d-aspartate receptor (NMDAR) antibody encephalitis appears common in the world, but the number of clinical cases in Vietnam which were recorded is rare. CASE REPORT: We describe two new cases of disease in recent years with the aim of contributing to diagnosis and treatment experiences. These cases were noted over the past 3 years with the patients who have been treated at lower levels but have no results. They came to us when symptoms became worse and therefore required prolonged treatment with special intensive care facilities. The atypical and easily confused symptoms are the reasons that make the disease be detected late; leading to a much higher cost of treatment and the complication may appear in the patient. In the past, patients with these manifestations were diagnosed with unexplained encephalitis and severe sequelae or death. Autoimmune encephalitis has many types; NMDA encephalitis associated with ovarian teratoma is the most common autoimmune encephalitis in young women. CONCLUSION: In conclusion, based on the case report, we hope to contribute some experiences on the diagnosis and the strategy in early treatment. With most female patients at very young age, early treatment to avoid complications will help patients have a quality life and maintain reproductive function. Republic of Macedonia 2019-12-20 /pmc/articles/PMC7084035/ /pubmed/32215098 http://dx.doi.org/10.3889/oamjms.2019.839 Text en Copyright: © 2019 Nguyen Phuong Tu, Pham Ba Nha, Nguyen Duy Hung, Nguyen Hoang Minh, Hoang Ngoc Anh, Thien Chu Dinh. http://creativecommons.org/licenses/CC BY-NC/4.0 This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License (CC BY-NC 4.0)
spellingShingle Basic and Clinical Medical Researches in Vietnam
Tu, Nguyen Phuong
Nha, Pham Ba
Hung, Nguyen Duy
Minh, Nguyen Hoang
Anh, Hoang Ngoc
Dinh, Thien Chu
Treatment of Anti–NMDA Receptor Encephalitis with Ovarian Teratoma Removal: A Literature Review and Two Case Reports
title Treatment of Anti–NMDA Receptor Encephalitis with Ovarian Teratoma Removal: A Literature Review and Two Case Reports
title_full Treatment of Anti–NMDA Receptor Encephalitis with Ovarian Teratoma Removal: A Literature Review and Two Case Reports
title_fullStr Treatment of Anti–NMDA Receptor Encephalitis with Ovarian Teratoma Removal: A Literature Review and Two Case Reports
title_full_unstemmed Treatment of Anti–NMDA Receptor Encephalitis with Ovarian Teratoma Removal: A Literature Review and Two Case Reports
title_short Treatment of Anti–NMDA Receptor Encephalitis with Ovarian Teratoma Removal: A Literature Review and Two Case Reports
title_sort treatment of anti–nmda receptor encephalitis with ovarian teratoma removal: a literature review and two case reports
topic Basic and Clinical Medical Researches in Vietnam
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7084035/
https://www.ncbi.nlm.nih.gov/pubmed/32215098
http://dx.doi.org/10.3889/oamjms.2019.839
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