Composition-based prediction and rational manipulation of prion-like domain recruitment to stress granules

Mutations in a number of stress granule-associated proteins have been linked to various neurodegenerative diseases. Several of these mutations are found in aggregation-prone prion-like domains (PrLDs) within these proteins. In this work, we examine the sequence features governing PrLD localization t...

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Detalles Bibliográficos
Autores principales: Boncella, Amy E., Shattuck, Jenifer E., Cascarina, Sean M., Paul, Kacy R., Baer, Matthew H., Fomicheva, Anastasia, Lamb, Andrew K., Ross, Eric D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: National Academy of Sciences 2020
Materias:
Biological Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7084078/
https://www.ncbi.nlm.nih.gov/pubmed/32127480
http://dx.doi.org/10.1073/pnas.1912723117

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