Cargando…
Stem Cell Aging in Skeletal Muscle Regeneration and Disease
Skeletal muscle comprises 30–40% of the weight of a healthy human body and is required for voluntary movements in humans. Mature skeletal muscle is formed by multinuclear cells, which are called myofibers. Formation of myofibers depends on the proliferation, differentiation, and fusion of muscle pro...
Autores principales: | , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2020
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7084237/ https://www.ncbi.nlm.nih.gov/pubmed/32155842 http://dx.doi.org/10.3390/ijms21051830 |
_version_ | 1783508675475800064 |
---|---|
author | Yamakawa, Hiroyuki Kusumoto, Dai Hashimoto, Hisayuki Yuasa, Shinsuke |
author_facet | Yamakawa, Hiroyuki Kusumoto, Dai Hashimoto, Hisayuki Yuasa, Shinsuke |
author_sort | Yamakawa, Hiroyuki |
collection | PubMed |
description | Skeletal muscle comprises 30–40% of the weight of a healthy human body and is required for voluntary movements in humans. Mature skeletal muscle is formed by multinuclear cells, which are called myofibers. Formation of myofibers depends on the proliferation, differentiation, and fusion of muscle progenitor cells during development and after injury. Muscle progenitor cells are derived from muscle satellite (stem) cells (MuSCs), which reside on the surface of the myofiber but beneath the basement membrane. MuSCs play a central role in postnatal maintenance, growth, repair, and regeneration of skeletal muscle. In sedentary adult muscle, MuSCs are mitotically quiescent, but are promptly activated in response to muscle injury. Physiological and chronological aging induces MuSC aging, leading to an impaired regenerative capability. Importantly, in pathological situations, repetitive muscle injury induces early impairment of MuSCs due to stem cell aging and leads to early impairment of regeneration ability. In this review, we discuss (1) the role of MuSCs in muscle regeneration, (2) stem cell aging under physiological and pathological conditions, and (3) prospects related to clinical applications of controlling MuSCs. |
format | Online Article Text |
id | pubmed-7084237 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-70842372020-03-24 Stem Cell Aging in Skeletal Muscle Regeneration and Disease Yamakawa, Hiroyuki Kusumoto, Dai Hashimoto, Hisayuki Yuasa, Shinsuke Int J Mol Sci Review Skeletal muscle comprises 30–40% of the weight of a healthy human body and is required for voluntary movements in humans. Mature skeletal muscle is formed by multinuclear cells, which are called myofibers. Formation of myofibers depends on the proliferation, differentiation, and fusion of muscle progenitor cells during development and after injury. Muscle progenitor cells are derived from muscle satellite (stem) cells (MuSCs), which reside on the surface of the myofiber but beneath the basement membrane. MuSCs play a central role in postnatal maintenance, growth, repair, and regeneration of skeletal muscle. In sedentary adult muscle, MuSCs are mitotically quiescent, but are promptly activated in response to muscle injury. Physiological and chronological aging induces MuSC aging, leading to an impaired regenerative capability. Importantly, in pathological situations, repetitive muscle injury induces early impairment of MuSCs due to stem cell aging and leads to early impairment of regeneration ability. In this review, we discuss (1) the role of MuSCs in muscle regeneration, (2) stem cell aging under physiological and pathological conditions, and (3) prospects related to clinical applications of controlling MuSCs. MDPI 2020-03-06 /pmc/articles/PMC7084237/ /pubmed/32155842 http://dx.doi.org/10.3390/ijms21051830 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Yamakawa, Hiroyuki Kusumoto, Dai Hashimoto, Hisayuki Yuasa, Shinsuke Stem Cell Aging in Skeletal Muscle Regeneration and Disease |
title | Stem Cell Aging in Skeletal Muscle Regeneration and Disease |
title_full | Stem Cell Aging in Skeletal Muscle Regeneration and Disease |
title_fullStr | Stem Cell Aging in Skeletal Muscle Regeneration and Disease |
title_full_unstemmed | Stem Cell Aging in Skeletal Muscle Regeneration and Disease |
title_short | Stem Cell Aging in Skeletal Muscle Regeneration and Disease |
title_sort | stem cell aging in skeletal muscle regeneration and disease |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7084237/ https://www.ncbi.nlm.nih.gov/pubmed/32155842 http://dx.doi.org/10.3390/ijms21051830 |
work_keys_str_mv | AT yamakawahiroyuki stemcellaginginskeletalmuscleregenerationanddisease AT kusumotodai stemcellaginginskeletalmuscleregenerationanddisease AT hashimotohisayuki stemcellaginginskeletalmuscleregenerationanddisease AT yuasashinsuke stemcellaginginskeletalmuscleregenerationanddisease |