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Stem Cell Aging in Skeletal Muscle Regeneration and Disease

Skeletal muscle comprises 30–40% of the weight of a healthy human body and is required for voluntary movements in humans. Mature skeletal muscle is formed by multinuclear cells, which are called myofibers. Formation of myofibers depends on the proliferation, differentiation, and fusion of muscle pro...

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Detalles Bibliográficos
Autores principales: Yamakawa, Hiroyuki, Kusumoto, Dai, Hashimoto, Hisayuki, Yuasa, Shinsuke
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7084237/
https://www.ncbi.nlm.nih.gov/pubmed/32155842
http://dx.doi.org/10.3390/ijms21051830
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author Yamakawa, Hiroyuki
Kusumoto, Dai
Hashimoto, Hisayuki
Yuasa, Shinsuke
author_facet Yamakawa, Hiroyuki
Kusumoto, Dai
Hashimoto, Hisayuki
Yuasa, Shinsuke
author_sort Yamakawa, Hiroyuki
collection PubMed
description Skeletal muscle comprises 30–40% of the weight of a healthy human body and is required for voluntary movements in humans. Mature skeletal muscle is formed by multinuclear cells, which are called myofibers. Formation of myofibers depends on the proliferation, differentiation, and fusion of muscle progenitor cells during development and after injury. Muscle progenitor cells are derived from muscle satellite (stem) cells (MuSCs), which reside on the surface of the myofiber but beneath the basement membrane. MuSCs play a central role in postnatal maintenance, growth, repair, and regeneration of skeletal muscle. In sedentary adult muscle, MuSCs are mitotically quiescent, but are promptly activated in response to muscle injury. Physiological and chronological aging induces MuSC aging, leading to an impaired regenerative capability. Importantly, in pathological situations, repetitive muscle injury induces early impairment of MuSCs due to stem cell aging and leads to early impairment of regeneration ability. In this review, we discuss (1) the role of MuSCs in muscle regeneration, (2) stem cell aging under physiological and pathological conditions, and (3) prospects related to clinical applications of controlling MuSCs.
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spelling pubmed-70842372020-03-24 Stem Cell Aging in Skeletal Muscle Regeneration and Disease Yamakawa, Hiroyuki Kusumoto, Dai Hashimoto, Hisayuki Yuasa, Shinsuke Int J Mol Sci Review Skeletal muscle comprises 30–40% of the weight of a healthy human body and is required for voluntary movements in humans. Mature skeletal muscle is formed by multinuclear cells, which are called myofibers. Formation of myofibers depends on the proliferation, differentiation, and fusion of muscle progenitor cells during development and after injury. Muscle progenitor cells are derived from muscle satellite (stem) cells (MuSCs), which reside on the surface of the myofiber but beneath the basement membrane. MuSCs play a central role in postnatal maintenance, growth, repair, and regeneration of skeletal muscle. In sedentary adult muscle, MuSCs are mitotically quiescent, but are promptly activated in response to muscle injury. Physiological and chronological aging induces MuSC aging, leading to an impaired regenerative capability. Importantly, in pathological situations, repetitive muscle injury induces early impairment of MuSCs due to stem cell aging and leads to early impairment of regeneration ability. In this review, we discuss (1) the role of MuSCs in muscle regeneration, (2) stem cell aging under physiological and pathological conditions, and (3) prospects related to clinical applications of controlling MuSCs. MDPI 2020-03-06 /pmc/articles/PMC7084237/ /pubmed/32155842 http://dx.doi.org/10.3390/ijms21051830 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Yamakawa, Hiroyuki
Kusumoto, Dai
Hashimoto, Hisayuki
Yuasa, Shinsuke
Stem Cell Aging in Skeletal Muscle Regeneration and Disease
title Stem Cell Aging in Skeletal Muscle Regeneration and Disease
title_full Stem Cell Aging in Skeletal Muscle Regeneration and Disease
title_fullStr Stem Cell Aging in Skeletal Muscle Regeneration and Disease
title_full_unstemmed Stem Cell Aging in Skeletal Muscle Regeneration and Disease
title_short Stem Cell Aging in Skeletal Muscle Regeneration and Disease
title_sort stem cell aging in skeletal muscle regeneration and disease
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7084237/
https://www.ncbi.nlm.nih.gov/pubmed/32155842
http://dx.doi.org/10.3390/ijms21051830
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