Transglutaminase 3 Reduces the Severity of Psoriasis in Imiquimod-Treated Mouse Skin

Four transglutaminase (TG) isoforms have been detected in epidermal keratinocytes: TG1, TG2, TG3, and TG5. Except for TG1 and TG3, their contribution to keratinocyte development and structure remains undefined. In this paper, we focused on the roles of TG2 and TG3 in imiquimod-induced psoriasis in m...

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Detalles Bibliográficos
Autores principales: Piro, Maria Cristina, Ventura, Alessandra, Smirnov, Artem, Saggini, Andrea, Lena, Anna Maria, Mauriello, Alessandro, Bianchi, Luca, Melino, Gerry, Candi, Eleonora
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7084269/
https://www.ncbi.nlm.nih.gov/pubmed/32106600
http://dx.doi.org/10.3390/ijms21051566
Descripción
Sumario:Four transglutaminase (TG) isoforms have been detected in epidermal keratinocytes: TG1, TG2, TG3, and TG5. Except for TG1 and TG3, their contribution to keratinocyte development and structure remains undefined. In this paper, we focused on the roles of TG2 and TG3 in imiquimod-induced psoriasis in mouse skin. We evaluated the severity of psoriasis markers in the skin of imiquimod-treated TG3 null and TG2 null mice. Our results showed that compromised TG3KO mouse skin was more responsive than WT or TG2KO mouse skin to the action of the pro-inflammatory drug imiquimod.

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