Transglutaminase 3 Reduces the Severity of Psoriasis in Imiquimod-Treated Mouse Skin

Four transglutaminase (TG) isoforms have been detected in epidermal keratinocytes: TG1, TG2, TG3, and TG5. Except for TG1 and TG3, their contribution to keratinocyte development and structure remains undefined. In this paper, we focused on the roles of TG2 and TG3 in imiquimod-induced psoriasis in m...

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Autores principales: Piro, Maria Cristina, Ventura, Alessandra, Smirnov, Artem, Saggini, Andrea, Lena, Anna Maria, Mauriello, Alessandro, Bianchi, Luca, Melino, Gerry, Candi, Eleonora
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7084269/
https://www.ncbi.nlm.nih.gov/pubmed/32106600
http://dx.doi.org/10.3390/ijms21051566
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author Piro, Maria Cristina
Ventura, Alessandra
Smirnov, Artem
Saggini, Andrea
Lena, Anna Maria
Mauriello, Alessandro
Bianchi, Luca
Melino, Gerry
Candi, Eleonora
author_facet Piro, Maria Cristina
Ventura, Alessandra
Smirnov, Artem
Saggini, Andrea
Lena, Anna Maria
Mauriello, Alessandro
Bianchi, Luca
Melino, Gerry
Candi, Eleonora
author_sort Piro, Maria Cristina
collection PubMed
description Four transglutaminase (TG) isoforms have been detected in epidermal keratinocytes: TG1, TG2, TG3, and TG5. Except for TG1 and TG3, their contribution to keratinocyte development and structure remains undefined. In this paper, we focused on the roles of TG2 and TG3 in imiquimod-induced psoriasis in mouse skin. We evaluated the severity of psoriasis markers in the skin of imiquimod-treated TG3 null and TG2 null mice. Our results showed that compromised TG3KO mouse skin was more responsive than WT or TG2KO mouse skin to the action of the pro-inflammatory drug imiquimod.
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spelling pubmed-70842692020-03-24 Transglutaminase 3 Reduces the Severity of Psoriasis in Imiquimod-Treated Mouse Skin Piro, Maria Cristina Ventura, Alessandra Smirnov, Artem Saggini, Andrea Lena, Anna Maria Mauriello, Alessandro Bianchi, Luca Melino, Gerry Candi, Eleonora Int J Mol Sci Communication Four transglutaminase (TG) isoforms have been detected in epidermal keratinocytes: TG1, TG2, TG3, and TG5. Except for TG1 and TG3, their contribution to keratinocyte development and structure remains undefined. In this paper, we focused on the roles of TG2 and TG3 in imiquimod-induced psoriasis in mouse skin. We evaluated the severity of psoriasis markers in the skin of imiquimod-treated TG3 null and TG2 null mice. Our results showed that compromised TG3KO mouse skin was more responsive than WT or TG2KO mouse skin to the action of the pro-inflammatory drug imiquimod. MDPI 2020-02-25 /pmc/articles/PMC7084269/ /pubmed/32106600 http://dx.doi.org/10.3390/ijms21051566 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Communication
Piro, Maria Cristina
Ventura, Alessandra
Smirnov, Artem
Saggini, Andrea
Lena, Anna Maria
Mauriello, Alessandro
Bianchi, Luca
Melino, Gerry
Candi, Eleonora
Transglutaminase 3 Reduces the Severity of Psoriasis in Imiquimod-Treated Mouse Skin
title Transglutaminase 3 Reduces the Severity of Psoriasis in Imiquimod-Treated Mouse Skin
title_full Transglutaminase 3 Reduces the Severity of Psoriasis in Imiquimod-Treated Mouse Skin
title_fullStr Transglutaminase 3 Reduces the Severity of Psoriasis in Imiquimod-Treated Mouse Skin
title_full_unstemmed Transglutaminase 3 Reduces the Severity of Psoriasis in Imiquimod-Treated Mouse Skin
title_short Transglutaminase 3 Reduces the Severity of Psoriasis in Imiquimod-Treated Mouse Skin
title_sort transglutaminase 3 reduces the severity of psoriasis in imiquimod-treated mouse skin
topic Communication
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7084269/
https://www.ncbi.nlm.nih.gov/pubmed/32106600
http://dx.doi.org/10.3390/ijms21051566
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