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Characterizing the Neurodevelopmental Pesticide Exposome in a Children’s Agricultural Cohort
The exposome provides a conceptual model for identifying and characterizing lifetime environmental exposures and resultant health effects. In this study, we applied key exposome concepts to look specifically at the neurodevelopmental pesticide exposome, which focuses on exposures to pesticides that...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7084326/ https://www.ncbi.nlm.nih.gov/pubmed/32106530 http://dx.doi.org/10.3390/ijerph17051479 |
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author | Bennett, Breana Workman, Tomomi Smith, Marissa N. Griffith, William C. Thompson, Beti Faustman, Elaine M. |
author_facet | Bennett, Breana Workman, Tomomi Smith, Marissa N. Griffith, William C. Thompson, Beti Faustman, Elaine M. |
author_sort | Bennett, Breana |
collection | PubMed |
description | The exposome provides a conceptual model for identifying and characterizing lifetime environmental exposures and resultant health effects. In this study, we applied key exposome concepts to look specifically at the neurodevelopmental pesticide exposome, which focuses on exposures to pesticides that have the potential to cause an adverse neurodevelopmental impact. Using household dust samples from a children’s agricultural cohort located in the Yakima Valley of Washington state, we identified 87 individual pesticides using liquid chromatography-tandem mass spectrometry. A total of 47 of these have evidence of neurotoxicity included in the Environmental Protection Agency (EPA) (re)registration materials. We used a mixed effects model to model trends in pesticide exposure. Over the two study years (2005 and 2011), we demonstrate a significant decrease in the neurodevelopmental pesticide exposome across the cohort, but particularly among farmworker households. Additional analysis with a non-parametric binomial analysis that weighted the levels of potentially neurotoxic pesticides detected in household dust by their reference doses revealed that the decrease in potentially neurotoxic pesticides was largely a result of decreases in some of the most potent neurotoxicants. Overall, this study provides evidence that the neurodevelopmental pesticide exposome framework is a useful tool in assessing the effectiveness of specific interventions in reducing exposure as well as setting priorities for future targeted actions. |
format | Online Article Text |
id | pubmed-7084326 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-70843262020-03-24 Characterizing the Neurodevelopmental Pesticide Exposome in a Children’s Agricultural Cohort Bennett, Breana Workman, Tomomi Smith, Marissa N. Griffith, William C. Thompson, Beti Faustman, Elaine M. Int J Environ Res Public Health Article The exposome provides a conceptual model for identifying and characterizing lifetime environmental exposures and resultant health effects. In this study, we applied key exposome concepts to look specifically at the neurodevelopmental pesticide exposome, which focuses on exposures to pesticides that have the potential to cause an adverse neurodevelopmental impact. Using household dust samples from a children’s agricultural cohort located in the Yakima Valley of Washington state, we identified 87 individual pesticides using liquid chromatography-tandem mass spectrometry. A total of 47 of these have evidence of neurotoxicity included in the Environmental Protection Agency (EPA) (re)registration materials. We used a mixed effects model to model trends in pesticide exposure. Over the two study years (2005 and 2011), we demonstrate a significant decrease in the neurodevelopmental pesticide exposome across the cohort, but particularly among farmworker households. Additional analysis with a non-parametric binomial analysis that weighted the levels of potentially neurotoxic pesticides detected in household dust by their reference doses revealed that the decrease in potentially neurotoxic pesticides was largely a result of decreases in some of the most potent neurotoxicants. Overall, this study provides evidence that the neurodevelopmental pesticide exposome framework is a useful tool in assessing the effectiveness of specific interventions in reducing exposure as well as setting priorities for future targeted actions. MDPI 2020-02-25 2020-03 /pmc/articles/PMC7084326/ /pubmed/32106530 http://dx.doi.org/10.3390/ijerph17051479 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Bennett, Breana Workman, Tomomi Smith, Marissa N. Griffith, William C. Thompson, Beti Faustman, Elaine M. Characterizing the Neurodevelopmental Pesticide Exposome in a Children’s Agricultural Cohort |
title | Characterizing the Neurodevelopmental Pesticide Exposome in a Children’s Agricultural Cohort |
title_full | Characterizing the Neurodevelopmental Pesticide Exposome in a Children’s Agricultural Cohort |
title_fullStr | Characterizing the Neurodevelopmental Pesticide Exposome in a Children’s Agricultural Cohort |
title_full_unstemmed | Characterizing the Neurodevelopmental Pesticide Exposome in a Children’s Agricultural Cohort |
title_short | Characterizing the Neurodevelopmental Pesticide Exposome in a Children’s Agricultural Cohort |
title_sort | characterizing the neurodevelopmental pesticide exposome in a children’s agricultural cohort |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7084326/ https://www.ncbi.nlm.nih.gov/pubmed/32106530 http://dx.doi.org/10.3390/ijerph17051479 |
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