Cargando…

Characterizing the Neurodevelopmental Pesticide Exposome in a Children’s Agricultural Cohort

The exposome provides a conceptual model for identifying and characterizing lifetime environmental exposures and resultant health effects. In this study, we applied key exposome concepts to look specifically at the neurodevelopmental pesticide exposome, which focuses on exposures to pesticides that...

Descripción completa

Detalles Bibliográficos
Autores principales: Bennett, Breana, Workman, Tomomi, Smith, Marissa N., Griffith, William C., Thompson, Beti, Faustman, Elaine M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7084326/
https://www.ncbi.nlm.nih.gov/pubmed/32106530
http://dx.doi.org/10.3390/ijerph17051479
_version_ 1783508696021598208
author Bennett, Breana
Workman, Tomomi
Smith, Marissa N.
Griffith, William C.
Thompson, Beti
Faustman, Elaine M.
author_facet Bennett, Breana
Workman, Tomomi
Smith, Marissa N.
Griffith, William C.
Thompson, Beti
Faustman, Elaine M.
author_sort Bennett, Breana
collection PubMed
description The exposome provides a conceptual model for identifying and characterizing lifetime environmental exposures and resultant health effects. In this study, we applied key exposome concepts to look specifically at the neurodevelopmental pesticide exposome, which focuses on exposures to pesticides that have the potential to cause an adverse neurodevelopmental impact. Using household dust samples from a children’s agricultural cohort located in the Yakima Valley of Washington state, we identified 87 individual pesticides using liquid chromatography-tandem mass spectrometry. A total of 47 of these have evidence of neurotoxicity included in the Environmental Protection Agency (EPA) (re)registration materials. We used a mixed effects model to model trends in pesticide exposure. Over the two study years (2005 and 2011), we demonstrate a significant decrease in the neurodevelopmental pesticide exposome across the cohort, but particularly among farmworker households. Additional analysis with a non-parametric binomial analysis that weighted the levels of potentially neurotoxic pesticides detected in household dust by their reference doses revealed that the decrease in potentially neurotoxic pesticides was largely a result of decreases in some of the most potent neurotoxicants. Overall, this study provides evidence that the neurodevelopmental pesticide exposome framework is a useful tool in assessing the effectiveness of specific interventions in reducing exposure as well as setting priorities for future targeted actions.
format Online
Article
Text
id pubmed-7084326
institution National Center for Biotechnology Information
language English
publishDate 2020
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-70843262020-03-24 Characterizing the Neurodevelopmental Pesticide Exposome in a Children’s Agricultural Cohort Bennett, Breana Workman, Tomomi Smith, Marissa N. Griffith, William C. Thompson, Beti Faustman, Elaine M. Int J Environ Res Public Health Article The exposome provides a conceptual model for identifying and characterizing lifetime environmental exposures and resultant health effects. In this study, we applied key exposome concepts to look specifically at the neurodevelopmental pesticide exposome, which focuses on exposures to pesticides that have the potential to cause an adverse neurodevelopmental impact. Using household dust samples from a children’s agricultural cohort located in the Yakima Valley of Washington state, we identified 87 individual pesticides using liquid chromatography-tandem mass spectrometry. A total of 47 of these have evidence of neurotoxicity included in the Environmental Protection Agency (EPA) (re)registration materials. We used a mixed effects model to model trends in pesticide exposure. Over the two study years (2005 and 2011), we demonstrate a significant decrease in the neurodevelopmental pesticide exposome across the cohort, but particularly among farmworker households. Additional analysis with a non-parametric binomial analysis that weighted the levels of potentially neurotoxic pesticides detected in household dust by their reference doses revealed that the decrease in potentially neurotoxic pesticides was largely a result of decreases in some of the most potent neurotoxicants. Overall, this study provides evidence that the neurodevelopmental pesticide exposome framework is a useful tool in assessing the effectiveness of specific interventions in reducing exposure as well as setting priorities for future targeted actions. MDPI 2020-02-25 2020-03 /pmc/articles/PMC7084326/ /pubmed/32106530 http://dx.doi.org/10.3390/ijerph17051479 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Bennett, Breana
Workman, Tomomi
Smith, Marissa N.
Griffith, William C.
Thompson, Beti
Faustman, Elaine M.
Characterizing the Neurodevelopmental Pesticide Exposome in a Children’s Agricultural Cohort
title Characterizing the Neurodevelopmental Pesticide Exposome in a Children’s Agricultural Cohort
title_full Characterizing the Neurodevelopmental Pesticide Exposome in a Children’s Agricultural Cohort
title_fullStr Characterizing the Neurodevelopmental Pesticide Exposome in a Children’s Agricultural Cohort
title_full_unstemmed Characterizing the Neurodevelopmental Pesticide Exposome in a Children’s Agricultural Cohort
title_short Characterizing the Neurodevelopmental Pesticide Exposome in a Children’s Agricultural Cohort
title_sort characterizing the neurodevelopmental pesticide exposome in a children’s agricultural cohort
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7084326/
https://www.ncbi.nlm.nih.gov/pubmed/32106530
http://dx.doi.org/10.3390/ijerph17051479
work_keys_str_mv AT bennettbreana characterizingtheneurodevelopmentalpesticideexposomeinachildrensagriculturalcohort
AT workmantomomi characterizingtheneurodevelopmentalpesticideexposomeinachildrensagriculturalcohort
AT smithmarissan characterizingtheneurodevelopmentalpesticideexposomeinachildrensagriculturalcohort
AT griffithwilliamc characterizingtheneurodevelopmentalpesticideexposomeinachildrensagriculturalcohort
AT thompsonbeti characterizingtheneurodevelopmentalpesticideexposomeinachildrensagriculturalcohort
AT faustmanelainem characterizingtheneurodevelopmentalpesticideexposomeinachildrensagriculturalcohort