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Influence of the Menstrual Cycle on Blood Markers of Muscle Damage and Inflammation Following Eccentric Exercise

The aim of this study was to evaluate whether the menstrual cycle and its underlying hormonal fluctuations affect muscle damage and inflammation in well-trained females following an eccentric exercise. Nineteen eumenorrheic women performed an eccentric squat-based exercise in the early follicular ph...

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Autores principales: Romero-Parra, Nuria, Barba-Moreno, Laura, Rael, Beatriz, Alfaro-Magallanes, Víctor M., Cupeiro, Rocío, Díaz, Ángel E., Calderón, Francisco J., Peinado, Ana B.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7084328/
https://www.ncbi.nlm.nih.gov/pubmed/32131554
http://dx.doi.org/10.3390/ijerph17051618
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author Romero-Parra, Nuria
Barba-Moreno, Laura
Rael, Beatriz
Alfaro-Magallanes, Víctor M.
Cupeiro, Rocío
Díaz, Ángel E.
Calderón, Francisco J.
Peinado, Ana B.
author_facet Romero-Parra, Nuria
Barba-Moreno, Laura
Rael, Beatriz
Alfaro-Magallanes, Víctor M.
Cupeiro, Rocío
Díaz, Ángel E.
Calderón, Francisco J.
Peinado, Ana B.
author_sort Romero-Parra, Nuria
collection PubMed
description The aim of this study was to evaluate whether the menstrual cycle and its underlying hormonal fluctuations affect muscle damage and inflammation in well-trained females following an eccentric exercise. Nineteen eumenorrheic women performed an eccentric squat-based exercise in the early follicular phase, late follicular phase and mid-luteal phase of their menstrual cycle. Sex hormones and blood markers of muscle damage and inflammation –creatine kinase, myoglobin, lactate dehydrogenase, interleukin-6, tumoral necrosis factor-α, and C reactive protein– were analyzed in each phase. No effect of menstrual cycle phase was observed (p > 0.05), while an interaction for interleukin-6 was shown (p = 0.047). Accordingly, a moderate effect size [0.68 (0.53)–0.84 (0.74)], indicated that interleukin-6 values 2 h post-trial (2.07 ± 1.26 pg/mL) were likely to be higher than baseline (1.59 ± 0.33 pg/mL), 24 h (1.50 ± 0.01 pg/mL) and 48 h (1.54 ± 0.13 pg/mL) in the mid-luteal phase. Blood markers of muscle damage and inflammation were not affected by the menstrual cycle in well-trained women. The eccentric exercise barely triggered muscle damage and hence, no inflammation was observed, possibly due to participants training status. The mid-luteal phase was the only phase reflecting a possible inflammatory response in terms of interleukin-6, although further factors than sex hormones seem to be responsible for this finding.
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spelling pubmed-70843282020-03-24 Influence of the Menstrual Cycle on Blood Markers of Muscle Damage and Inflammation Following Eccentric Exercise Romero-Parra, Nuria Barba-Moreno, Laura Rael, Beatriz Alfaro-Magallanes, Víctor M. Cupeiro, Rocío Díaz, Ángel E. Calderón, Francisco J. Peinado, Ana B. Int J Environ Res Public Health Article The aim of this study was to evaluate whether the menstrual cycle and its underlying hormonal fluctuations affect muscle damage and inflammation in well-trained females following an eccentric exercise. Nineteen eumenorrheic women performed an eccentric squat-based exercise in the early follicular phase, late follicular phase and mid-luteal phase of their menstrual cycle. Sex hormones and blood markers of muscle damage and inflammation –creatine kinase, myoglobin, lactate dehydrogenase, interleukin-6, tumoral necrosis factor-α, and C reactive protein– were analyzed in each phase. No effect of menstrual cycle phase was observed (p > 0.05), while an interaction for interleukin-6 was shown (p = 0.047). Accordingly, a moderate effect size [0.68 (0.53)–0.84 (0.74)], indicated that interleukin-6 values 2 h post-trial (2.07 ± 1.26 pg/mL) were likely to be higher than baseline (1.59 ± 0.33 pg/mL), 24 h (1.50 ± 0.01 pg/mL) and 48 h (1.54 ± 0.13 pg/mL) in the mid-luteal phase. Blood markers of muscle damage and inflammation were not affected by the menstrual cycle in well-trained women. The eccentric exercise barely triggered muscle damage and hence, no inflammation was observed, possibly due to participants training status. The mid-luteal phase was the only phase reflecting a possible inflammatory response in terms of interleukin-6, although further factors than sex hormones seem to be responsible for this finding. MDPI 2020-03-02 2020-03 /pmc/articles/PMC7084328/ /pubmed/32131554 http://dx.doi.org/10.3390/ijerph17051618 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Romero-Parra, Nuria
Barba-Moreno, Laura
Rael, Beatriz
Alfaro-Magallanes, Víctor M.
Cupeiro, Rocío
Díaz, Ángel E.
Calderón, Francisco J.
Peinado, Ana B.
Influence of the Menstrual Cycle on Blood Markers of Muscle Damage and Inflammation Following Eccentric Exercise
title Influence of the Menstrual Cycle on Blood Markers of Muscle Damage and Inflammation Following Eccentric Exercise
title_full Influence of the Menstrual Cycle on Blood Markers of Muscle Damage and Inflammation Following Eccentric Exercise
title_fullStr Influence of the Menstrual Cycle on Blood Markers of Muscle Damage and Inflammation Following Eccentric Exercise
title_full_unstemmed Influence of the Menstrual Cycle on Blood Markers of Muscle Damage and Inflammation Following Eccentric Exercise
title_short Influence of the Menstrual Cycle on Blood Markers of Muscle Damage and Inflammation Following Eccentric Exercise
title_sort influence of the menstrual cycle on blood markers of muscle damage and inflammation following eccentric exercise
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7084328/
https://www.ncbi.nlm.nih.gov/pubmed/32131554
http://dx.doi.org/10.3390/ijerph17051618
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