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Generation of New Isogenic Models of Huntington’s Disease Using CRISPR-Cas9 Technology

Huntington’s disease (HD) is a fatal neurodegenerative disorder caused by the expansion of CAG repeats in exon 1 of the huntingtin gene (HTT). Despite its monogenic nature, HD pathogenesis is still not fully understood, and no effective therapy is available to patients. The development of new techni...

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Detalles Bibliográficos
Autores principales:	Dabrowska, Magdalena, Ciolak, Agata, Kozlowska, Emilia, Fiszer, Agnieszka, Olejniczak, Marta
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2020
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7084361/ https://www.ncbi.nlm.nih.gov/pubmed/32182692 http://dx.doi.org/10.3390/ijms21051854

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