Discovery of 1-Pyrimidinyl-2-Aryl-4,6-Dihydropyrrolo [3,4-d]Imidazole-5(1H)-Carboxamide as a Novel JNK Inhibitor

We designed and synthesized 1-pyrimidinyl-2-aryl-4, 6-dihydropyrrolo [3,4-d] imidazole-5(1H)-carboxamide derivatives as selective inhibitors of c-Jun-N-terminal Kinase 3 (JNK3), a target for the treatment of neurodegenerative diseases. Based on the compounds found in previous studies, a novel scaffo...

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Detalles Bibliográficos
Autores principales: Jang, Miyoung, Oh, Youri, Cho, Hyunwook, Yang, Songyi, Moon, Hyungwoo, Im, Daseul, Hah, Jung-Mi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7084495/
https://www.ncbi.nlm.nih.gov/pubmed/32131443
http://dx.doi.org/10.3390/ijms21051698

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7084495/
https://www.ncbi.nlm.nih.gov/pubmed/32131443
http://dx.doi.org/10.3390/ijms21051698

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