Acid Ceramidase Depletion Impairs Neuronal Survival and Induces Morphological Defects in Neurites Associated with Altered Gene Transcription and Sphingolipid Content

The ASAH1 gene encodes acid ceramidase (AC), an enzyme that is implicated in the metabolism of ceramide (Cer). Mutations in the ASAH1 gene cause two different disorders, Farber disease (FD), a rare lysosomal storage disorder, and a rare form of spinal muscular atrophy combined with progressive myocl...

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Detalles Bibliográficos
Autores principales: Kyriakou, Kalia, W. Lederer, Carsten, Kleanthous, Marina, Drousiotou, Anthi, Malekkou, Anna
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7084529/
https://www.ncbi.nlm.nih.gov/pubmed/32111095
http://dx.doi.org/10.3390/ijms21051607

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7084529/
https://www.ncbi.nlm.nih.gov/pubmed/32111095
http://dx.doi.org/10.3390/ijms21051607

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