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Obatoclax, a Pan-BCL-2 Inhibitor, Downregulates Survivin to Induce Apoptosis in Human Colorectal Carcinoma Cells Via Suppressing WNT/β-catenin Signaling

Colorectal cancer (CRC) is a highly prevailing cancer and the fourth leading cause of cancer mortality worldwide. Aberrant expression of antiapoptotic BCL-2 family proteins is closely linked to neoplastic progression and chemoresistance. Obatoclax is a clinically developed drug, which binds antiapop...

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Detalles Bibliográficos
Autores principales:	Or, Chi-Hung R., Huang, Chiao-Wen, Chang, Ching-Chin, Lai, You-Chen, Chen, Yi-Ju, Chang, Chia-Che
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2020
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7084590/ https://www.ncbi.nlm.nih.gov/pubmed/32150830 http://dx.doi.org/10.3390/ijms21051773

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