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What Are the Molecular Mechanisms by Which Functional Bacterial Amyloids Influence Amyloid Beta Deposition and Neuroinflammation in Neurodegenerative Disorders?

Despite the enormous literature documenting the importance of amyloid beta (Aβ) protein in Alzheimer’s disease, we do not know how Aβ aggregation is initiated and why it has its unique distribution in the brain. In vivo and in vitro evidence has been developed to suggest that functional microbial am...

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Detalles Bibliográficos
Autores principales: Friedland, Robert P., McMillan, Joseph D., Kurlawala, Zimple
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7084682/
https://www.ncbi.nlm.nih.gov/pubmed/32121263
http://dx.doi.org/10.3390/ijms21051652
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author Friedland, Robert P.
McMillan, Joseph D.
Kurlawala, Zimple
author_facet Friedland, Robert P.
McMillan, Joseph D.
Kurlawala, Zimple
author_sort Friedland, Robert P.
collection PubMed
description Despite the enormous literature documenting the importance of amyloid beta (Aβ) protein in Alzheimer’s disease, we do not know how Aβ aggregation is initiated and why it has its unique distribution in the brain. In vivo and in vitro evidence has been developed to suggest that functional microbial amyloid proteins produced in the gut may cross-seed Aβ aggregation and prime the innate immune system to have an enhanced and pathogenic response to neuronal amyloids. In this commentary, we summarize the molecular mechanisms by which the microbiota may initiate and sustain the pathogenic processes of neurodegeneration in aging.
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spelling pubmed-70846822020-03-24 What Are the Molecular Mechanisms by Which Functional Bacterial Amyloids Influence Amyloid Beta Deposition and Neuroinflammation in Neurodegenerative Disorders? Friedland, Robert P. McMillan, Joseph D. Kurlawala, Zimple Int J Mol Sci Commentary Despite the enormous literature documenting the importance of amyloid beta (Aβ) protein in Alzheimer’s disease, we do not know how Aβ aggregation is initiated and why it has its unique distribution in the brain. In vivo and in vitro evidence has been developed to suggest that functional microbial amyloid proteins produced in the gut may cross-seed Aβ aggregation and prime the innate immune system to have an enhanced and pathogenic response to neuronal amyloids. In this commentary, we summarize the molecular mechanisms by which the microbiota may initiate and sustain the pathogenic processes of neurodegeneration in aging. MDPI 2020-02-28 /pmc/articles/PMC7084682/ /pubmed/32121263 http://dx.doi.org/10.3390/ijms21051652 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Commentary
Friedland, Robert P.
McMillan, Joseph D.
Kurlawala, Zimple
What Are the Molecular Mechanisms by Which Functional Bacterial Amyloids Influence Amyloid Beta Deposition and Neuroinflammation in Neurodegenerative Disorders?
title What Are the Molecular Mechanisms by Which Functional Bacterial Amyloids Influence Amyloid Beta Deposition and Neuroinflammation in Neurodegenerative Disorders?
title_full What Are the Molecular Mechanisms by Which Functional Bacterial Amyloids Influence Amyloid Beta Deposition and Neuroinflammation in Neurodegenerative Disorders?
title_fullStr What Are the Molecular Mechanisms by Which Functional Bacterial Amyloids Influence Amyloid Beta Deposition and Neuroinflammation in Neurodegenerative Disorders?
title_full_unstemmed What Are the Molecular Mechanisms by Which Functional Bacterial Amyloids Influence Amyloid Beta Deposition and Neuroinflammation in Neurodegenerative Disorders?
title_short What Are the Molecular Mechanisms by Which Functional Bacterial Amyloids Influence Amyloid Beta Deposition and Neuroinflammation in Neurodegenerative Disorders?
title_sort what are the molecular mechanisms by which functional bacterial amyloids influence amyloid beta deposition and neuroinflammation in neurodegenerative disorders?
topic Commentary
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7084682/
https://www.ncbi.nlm.nih.gov/pubmed/32121263
http://dx.doi.org/10.3390/ijms21051652
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