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Female Infertility Associated with Blood Lead and Cadmium Levels

Lead and cadmium are known to be potential female reproductive toxins. However, studies on the relationship between these metals and infertility are limited. This study examines the association between self-reported infertility and blood lead and cadmium levels in US women by comparing metal levels...

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Autores principales: Lee, Sohyae, Min, Jin-young, Min, Kyoung-bok
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7084729/
https://www.ncbi.nlm.nih.gov/pubmed/32164251
http://dx.doi.org/10.3390/ijerph17051794
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author Lee, Sohyae
Min, Jin-young
Min, Kyoung-bok
author_facet Lee, Sohyae
Min, Jin-young
Min, Kyoung-bok
author_sort Lee, Sohyae
collection PubMed
description Lead and cadmium are known to be potential female reproductive toxins. However, studies on the relationship between these metals and infertility are limited. This study examines the association between self-reported infertility and blood lead and cadmium levels in US women by comparing metal levels in infertile and pregnant women. Data on blood lead, blood cadmium, and infertility from women aged 20–39 years who participated in the 2013–2014 and 2015–2016 National Health and Nutrition Examination Surveys were analyzed (n = 124, ‘pregnant’ n = 42, ‘infertile’ n = 82). Blood lead and cadmium levels were measured using inductively coupled plasma mass spectrometry, and infertility and pregnancy status were assessed using a self-reported questionnaire. Low blood lead and cadmium levels (geometric mean of blood lead = 0.50 µg/dL and blood cadmium = 0.26 µg/L) were positively associated with self-reported infertility after adjusting for confounding effects (odds ratio (OR) for lead per two-fold increase in blood metal levels = 2.60; 95% confidence interval (95% CI), 1.05–6.41 and OR for cadmium per two-fold increase = 1.84; 95% CI, 1.07–3.15). Although our findings require confirmation, they suggest that even low blood cadmium and lead levels may be deleterious to female fecundity.
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spelling pubmed-70847292020-03-24 Female Infertility Associated with Blood Lead and Cadmium Levels Lee, Sohyae Min, Jin-young Min, Kyoung-bok Int J Environ Res Public Health Article Lead and cadmium are known to be potential female reproductive toxins. However, studies on the relationship between these metals and infertility are limited. This study examines the association between self-reported infertility and blood lead and cadmium levels in US women by comparing metal levels in infertile and pregnant women. Data on blood lead, blood cadmium, and infertility from women aged 20–39 years who participated in the 2013–2014 and 2015–2016 National Health and Nutrition Examination Surveys were analyzed (n = 124, ‘pregnant’ n = 42, ‘infertile’ n = 82). Blood lead and cadmium levels were measured using inductively coupled plasma mass spectrometry, and infertility and pregnancy status were assessed using a self-reported questionnaire. Low blood lead and cadmium levels (geometric mean of blood lead = 0.50 µg/dL and blood cadmium = 0.26 µg/L) were positively associated with self-reported infertility after adjusting for confounding effects (odds ratio (OR) for lead per two-fold increase in blood metal levels = 2.60; 95% confidence interval (95% CI), 1.05–6.41 and OR for cadmium per two-fold increase = 1.84; 95% CI, 1.07–3.15). Although our findings require confirmation, they suggest that even low blood cadmium and lead levels may be deleterious to female fecundity. MDPI 2020-03-10 2020-03 /pmc/articles/PMC7084729/ /pubmed/32164251 http://dx.doi.org/10.3390/ijerph17051794 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Lee, Sohyae
Min, Jin-young
Min, Kyoung-bok
Female Infertility Associated with Blood Lead and Cadmium Levels
title Female Infertility Associated with Blood Lead and Cadmium Levels
title_full Female Infertility Associated with Blood Lead and Cadmium Levels
title_fullStr Female Infertility Associated with Blood Lead and Cadmium Levels
title_full_unstemmed Female Infertility Associated with Blood Lead and Cadmium Levels
title_short Female Infertility Associated with Blood Lead and Cadmium Levels
title_sort female infertility associated with blood lead and cadmium levels
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7084729/
https://www.ncbi.nlm.nih.gov/pubmed/32164251
http://dx.doi.org/10.3390/ijerph17051794
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