Estrogen-Related Receptor Alpha: An Under-Appreciated Potential Target for the Treatment of Metabolic Diseases

The estrogen-related receptor alpha (ESRRA) is an orphan nuclear receptor (NR) that significantly influences cellular metabolism. ESRRA is predominantly expressed in metabolically-active tissues and regulates the transcription of metabolic genes, including those involved in mitochondrial turnover an...

Descripción completa

Detalles Bibliográficos
Autores principales: Tripathi, Madhulika, Yen, Paul Michael, Singh, Brijesh Kumar
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7084735/
https://www.ncbi.nlm.nih.gov/pubmed/32121253
http://dx.doi.org/10.3390/ijms21051645
_version_ 1783508790926114816
author Tripathi, Madhulika
Yen, Paul Michael
Singh, Brijesh Kumar
author_facet Tripathi, Madhulika
Yen, Paul Michael
Singh, Brijesh Kumar
author_sort Tripathi, Madhulika
collection PubMed
description The estrogen-related receptor alpha (ESRRA) is an orphan nuclear receptor (NR) that significantly influences cellular metabolism. ESRRA is predominantly expressed in metabolically-active tissues and regulates the transcription of metabolic genes, including those involved in mitochondrial turnover and autophagy. Although ESRRA activity is well-characterized in several types of cancer, recent reports suggest that it also has an important role in metabolic diseases. This minireview focuses on the regulation of cellular metabolism and function by ESRRA and its potential as a target for the treatment of metabolic disorders.
format Online
Article
Text
id pubmed-7084735
institution National Center for Biotechnology Information
language English
publishDate 2020
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-70847352020-03-24 Estrogen-Related Receptor Alpha: An Under-Appreciated Potential Target for the Treatment of Metabolic Diseases Tripathi, Madhulika Yen, Paul Michael Singh, Brijesh Kumar Int J Mol Sci Review The estrogen-related receptor alpha (ESRRA) is an orphan nuclear receptor (NR) that significantly influences cellular metabolism. ESRRA is predominantly expressed in metabolically-active tissues and regulates the transcription of metabolic genes, including those involved in mitochondrial turnover and autophagy. Although ESRRA activity is well-characterized in several types of cancer, recent reports suggest that it also has an important role in metabolic diseases. This minireview focuses on the regulation of cellular metabolism and function by ESRRA and its potential as a target for the treatment of metabolic disorders. MDPI 2020-02-28 /pmc/articles/PMC7084735/ /pubmed/32121253 http://dx.doi.org/10.3390/ijms21051645 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Tripathi, Madhulika
Yen, Paul Michael
Singh, Brijesh Kumar
Estrogen-Related Receptor Alpha: An Under-Appreciated Potential Target for the Treatment of Metabolic Diseases
title Estrogen-Related Receptor Alpha: An Under-Appreciated Potential Target for the Treatment of Metabolic Diseases
title_full Estrogen-Related Receptor Alpha: An Under-Appreciated Potential Target for the Treatment of Metabolic Diseases
title_fullStr Estrogen-Related Receptor Alpha: An Under-Appreciated Potential Target for the Treatment of Metabolic Diseases
title_full_unstemmed Estrogen-Related Receptor Alpha: An Under-Appreciated Potential Target for the Treatment of Metabolic Diseases
title_short Estrogen-Related Receptor Alpha: An Under-Appreciated Potential Target for the Treatment of Metabolic Diseases
title_sort estrogen-related receptor alpha: an under-appreciated potential target for the treatment of metabolic diseases
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7084735/
https://www.ncbi.nlm.nih.gov/pubmed/32121253
http://dx.doi.org/10.3390/ijms21051645
work_keys_str_mv AT tripathimadhulika estrogenrelatedreceptoralphaanunderappreciatedpotentialtargetforthetreatmentofmetabolicdiseases
AT yenpaulmichael estrogenrelatedreceptoralphaanunderappreciatedpotentialtargetforthetreatmentofmetabolicdiseases
AT singhbrijeshkumar estrogenrelatedreceptoralphaanunderappreciatedpotentialtargetforthetreatmentofmetabolicdiseases

Ejemplares similares