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Biomarkers for the Noninvasive Diagnosis of Endometriosis: State of the Art and Future Perspectives

Background: Early and accurate diagnosis of endometriosis is crucial for the management of this benign, yet debilitating pathology. Despite the advances of modern medicine, there is no common ground regarding the pathophysiology of this disease as it continues to affect the quality of life of millio...

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Autores principales: Anastasiu, Costin Vlad, Moga, Marius Alexandru, Elena Neculau, Andrea, Bălan, Andreea, Scârneciu, Ioan, Dragomir, Roxana Maria, Dull, Ana-Maria, Chicea, Liana-Maria
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7084761/
https://www.ncbi.nlm.nih.gov/pubmed/32143439
http://dx.doi.org/10.3390/ijms21051750
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author Anastasiu, Costin Vlad
Moga, Marius Alexandru
Elena Neculau, Andrea
Bălan, Andreea
Scârneciu, Ioan
Dragomir, Roxana Maria
Dull, Ana-Maria
Chicea, Liana-Maria
author_facet Anastasiu, Costin Vlad
Moga, Marius Alexandru
Elena Neculau, Andrea
Bălan, Andreea
Scârneciu, Ioan
Dragomir, Roxana Maria
Dull, Ana-Maria
Chicea, Liana-Maria
author_sort Anastasiu, Costin Vlad
collection PubMed
description Background: Early and accurate diagnosis of endometriosis is crucial for the management of this benign, yet debilitating pathology. Despite the advances of modern medicine, there is no common ground regarding the pathophysiology of this disease as it continues to affect the quality of life of millions of women of reproductive age. The lack of specific symptoms often determines a belated diagnosis. The gold standard remains invasive, surgery followed by a histopathological exam. A biomarker or a panel of biomarkers is easy to measure, usually noninvasive, and could benefit the clinician in both diagnosing and monitoring the treatment response. Several studies have advanced the idea of biomarkers for endometriosis, thereby circumventing unnecessary invasive techniques. Our paper aims at harmonizing the results of these studies in the search of promising perspectives on early diagnosis. Methods: We selected the papers from Google Academic, PubMed, and CrossRef and reviewed recent articles from the literature, aiming to evaluate the effectiveness of various putative serum and urinary biomarkers for endometriosis. Results: The majority of studies focused on a panel of biomarkers, rather than a single biomarker and were unable to identify a single biomolecule or a panel of biomarkers with sufficient specificity and sensitivity in endometriosis. Conclusion: Noninvasive biomarkers, proteomics, genomics, and miRNA microarray may aid the diagnosis, but further research on larger datasets along with a better understanding of the pathophysiologic mechanisms are needed.
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spelling pubmed-70847612020-03-24 Biomarkers for the Noninvasive Diagnosis of Endometriosis: State of the Art and Future Perspectives Anastasiu, Costin Vlad Moga, Marius Alexandru Elena Neculau, Andrea Bălan, Andreea Scârneciu, Ioan Dragomir, Roxana Maria Dull, Ana-Maria Chicea, Liana-Maria Int J Mol Sci Review Background: Early and accurate diagnosis of endometriosis is crucial for the management of this benign, yet debilitating pathology. Despite the advances of modern medicine, there is no common ground regarding the pathophysiology of this disease as it continues to affect the quality of life of millions of women of reproductive age. The lack of specific symptoms often determines a belated diagnosis. The gold standard remains invasive, surgery followed by a histopathological exam. A biomarker or a panel of biomarkers is easy to measure, usually noninvasive, and could benefit the clinician in both diagnosing and monitoring the treatment response. Several studies have advanced the idea of biomarkers for endometriosis, thereby circumventing unnecessary invasive techniques. Our paper aims at harmonizing the results of these studies in the search of promising perspectives on early diagnosis. Methods: We selected the papers from Google Academic, PubMed, and CrossRef and reviewed recent articles from the literature, aiming to evaluate the effectiveness of various putative serum and urinary biomarkers for endometriosis. Results: The majority of studies focused on a panel of biomarkers, rather than a single biomarker and were unable to identify a single biomolecule or a panel of biomarkers with sufficient specificity and sensitivity in endometriosis. Conclusion: Noninvasive biomarkers, proteomics, genomics, and miRNA microarray may aid the diagnosis, but further research on larger datasets along with a better understanding of the pathophysiologic mechanisms are needed. MDPI 2020-03-04 /pmc/articles/PMC7084761/ /pubmed/32143439 http://dx.doi.org/10.3390/ijms21051750 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Anastasiu, Costin Vlad
Moga, Marius Alexandru
Elena Neculau, Andrea
Bălan, Andreea
Scârneciu, Ioan
Dragomir, Roxana Maria
Dull, Ana-Maria
Chicea, Liana-Maria
Biomarkers for the Noninvasive Diagnosis of Endometriosis: State of the Art and Future Perspectives
title Biomarkers for the Noninvasive Diagnosis of Endometriosis: State of the Art and Future Perspectives
title_full Biomarkers for the Noninvasive Diagnosis of Endometriosis: State of the Art and Future Perspectives
title_fullStr Biomarkers for the Noninvasive Diagnosis of Endometriosis: State of the Art and Future Perspectives
title_full_unstemmed Biomarkers for the Noninvasive Diagnosis of Endometriosis: State of the Art and Future Perspectives
title_short Biomarkers for the Noninvasive Diagnosis of Endometriosis: State of the Art and Future Perspectives
title_sort biomarkers for the noninvasive diagnosis of endometriosis: state of the art and future perspectives
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7084761/
https://www.ncbi.nlm.nih.gov/pubmed/32143439
http://dx.doi.org/10.3390/ijms21051750
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