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Transient Receptor Potential Canonical (TRPC) Channels as Modulators of Migration and Invasion

Calcium (Ca(2+)) is perhaps the most versatile signaling molecule in cells. Ca(2+) regulates a large number of key events in cells, ranging from gene transcription, motility, and contraction, to energy production and channel gating. To accomplish all these different functions, a multitude of channel...

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Detalles Bibliográficos
Autores principales: Asghar, Muhammad Yasir, Törnquist, Kid
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7084769/
https://www.ncbi.nlm.nih.gov/pubmed/32138386
http://dx.doi.org/10.3390/ijms21051739
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author Asghar, Muhammad Yasir
Törnquist, Kid
author_facet Asghar, Muhammad Yasir
Törnquist, Kid
author_sort Asghar, Muhammad Yasir
collection PubMed
description Calcium (Ca(2+)) is perhaps the most versatile signaling molecule in cells. Ca(2+) regulates a large number of key events in cells, ranging from gene transcription, motility, and contraction, to energy production and channel gating. To accomplish all these different functions, a multitude of channels, pumps, and transporters are necessary. A group of channels participating in these processes is the transient receptor potential (TRP) family of cation channels. These channels are divided into 29 subfamilies, and are differentially expressed in man, rodents, worms, and flies. One of these subfamilies is the transient receptor potential canonical (TRPC) family of channels. This ion channel family comprises of seven isoforms, labeled TRPC1–7. In man, six functional forms are expressed (TRPC1, TRPC3–7), whereas TRPC2 is a pseudogene; thus, not functionally expressed. In this review, we will describe the importance of the TRPC channels and their interacting molecular partners in the etiology of cancer, particularly in regard to regulating migration and invasion.
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spelling pubmed-70847692020-03-24 Transient Receptor Potential Canonical (TRPC) Channels as Modulators of Migration and Invasion Asghar, Muhammad Yasir Törnquist, Kid Int J Mol Sci Review Calcium (Ca(2+)) is perhaps the most versatile signaling molecule in cells. Ca(2+) regulates a large number of key events in cells, ranging from gene transcription, motility, and contraction, to energy production and channel gating. To accomplish all these different functions, a multitude of channels, pumps, and transporters are necessary. A group of channels participating in these processes is the transient receptor potential (TRP) family of cation channels. These channels are divided into 29 subfamilies, and are differentially expressed in man, rodents, worms, and flies. One of these subfamilies is the transient receptor potential canonical (TRPC) family of channels. This ion channel family comprises of seven isoforms, labeled TRPC1–7. In man, six functional forms are expressed (TRPC1, TRPC3–7), whereas TRPC2 is a pseudogene; thus, not functionally expressed. In this review, we will describe the importance of the TRPC channels and their interacting molecular partners in the etiology of cancer, particularly in regard to regulating migration and invasion. MDPI 2020-03-03 /pmc/articles/PMC7084769/ /pubmed/32138386 http://dx.doi.org/10.3390/ijms21051739 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Asghar, Muhammad Yasir
Törnquist, Kid
Transient Receptor Potential Canonical (TRPC) Channels as Modulators of Migration and Invasion
title Transient Receptor Potential Canonical (TRPC) Channels as Modulators of Migration and Invasion
title_full Transient Receptor Potential Canonical (TRPC) Channels as Modulators of Migration and Invasion
title_fullStr Transient Receptor Potential Canonical (TRPC) Channels as Modulators of Migration and Invasion
title_full_unstemmed Transient Receptor Potential Canonical (TRPC) Channels as Modulators of Migration and Invasion
title_short Transient Receptor Potential Canonical (TRPC) Channels as Modulators of Migration and Invasion
title_sort transient receptor potential canonical (trpc) channels as modulators of migration and invasion
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7084769/
https://www.ncbi.nlm.nih.gov/pubmed/32138386
http://dx.doi.org/10.3390/ijms21051739
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