Cargando…

Replication Protein A (RPA) Mediates Radio-Resistance of Glioblastoma Cancer Stem-Like Cells

Glioblastoma (GBM) is among the deadliest of solid tumors with median survival rates of approximately 12–15 months despite maximal therapeutic intervention. A rare population of self-renewing cells referred to as GBM cancer stem-like cells (GSCs) are believed to be the source of inevitable recurrenc...

Descripción completa

Detalles Bibliográficos
Autores principales:	Pedersen, Henriette, Anne Adanma Obara, Elisabeth, Elbæk, Kirstine Juul, Vitting-Serup, Kristoffer, Hamerlik, Petra
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2020
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7084771/ https://www.ncbi.nlm.nih.gov/pubmed/32111042 http://dx.doi.org/10.3390/ijms21051588

Ejemplares similares

SPT6-driven error-free DNA repair safeguards genomic stability of glioblastoma cancer stem-like cells
por: Obara, Elisabeth Anne Adanma, et al.
Publicado: (2020)

Perspective: targeting VEGF-A and YKL-40 in glioblastoma – matter matters
por: Holst, Camilla Bjørnbak, et al.
Publicado: (2021)

Radio-Resistance and DNA Repair in Pediatric Diffuse Midline Gliomas
por: Pedersen, Henriette, et al.
Publicado: (2020)

Targeting glioma stem‐like cell survival and chemoresistance through inhibition of lysine‐specific histone demethylase KDM2B
por: Staberg, Mikkel, et al.
Publicado: (2018)

Plasma IL-8 and ICOSLG as prognostic biomarkers in glioblastoma
por: Holst, Camilla Bjørnbak, et al.
Publicado: (2021)

Transcriptional changes induced by bevacizumab combination therapy in responding and non-responding recurrent glioblastoma patients
por: Urup, Thomas, et al.
Publicado: (2017)

Mapping of equine mesenchymal stromal cell surface proteomes for identification of specific markers using proteomics and gene expression analysis: an in vitro cross-sectional study
por: Bundgaard, Louise, et al.
Publicado: (2018)

Mass spectrometric analysis of the in vitro secretome from equine bone marrow-derived mesenchymal stromal cells to assess the effect of chondrogenic differentiation on response to interleukin-1β treatment
por: Bundgaard, Louise, et al.
Publicado: (2020)

Molecular basis for PrimPol recruitment to replication forks by RPA
por: Guilliam, Thomas A., et al.
Publicado: (2017)

Proper RPA acetylation promotes accurate DNA replication and repair
por: Gan, Xiaoli, et al.
Publicado: (2023)

Development of a New Enzyme-Linked Immunosorbent Assay (ELISA) for Measuring the Content of PACAP in Mammalian Tissue and Plasma
por: Obara, Elisabeth Anne Adanma, et al.
Publicado: (2023)

Dpb11 may function with RPA and DNA to initiate DNA replication
por: Bruck, Irina, et al.
Publicado: (2017)

Determinants of RPA megafoci localization to the nuclear periphery in response to replication stress
por: Kim, Seong Min, et al.
Publicado: (2022)

Distinct RPA functions promote eukaryotic DNA replication initiation and elongation
por: Pike, Alexandra M, et al.
Publicado: (2023)

Germline landscape of RPA1, RPA2 and RPA3 variants in pediatric malignancies: identification of RPA1 as a novel cancer predisposition candidate gene
por: Sharma, Richa, et al.
Publicado: (2023)

DOCK7 protects against replication stress by promoting RPA stability on chromatin
por: Gao, Ming, et al.
Publicado: (2021)

Most protein domains exist as variants with distinct functions across cells, tissues and diseases
por: Vitting-Seerup, Kristoffer
Publicado: (2023)

Stem cell cultures derived from pediatric brain tumors accurately model the originating tumors
por: Wenger, Anna, et al.
Publicado: (2017)

A dynamic model for replication protein A (RPA) function in DNA processing pathways
por: Fanning, Ellen, et al.
Publicado: (2006)

RPA complexes in Caenorhabditis elegans meiosis; unique roles in replication, meiotic recombination and apoptosis
por: Hefel, Adam, et al.
Publicado: (2021)

Crosstalk between CST and RPA regulates RAD51 activity during replication stress
por: Lei, Kai-Hang, et al.
Publicado: (2021)

Cancer Stem Cells and Glioblastoma: Time for Innovative Biomarkers of Radio-Resistance?
por: Pasqualetti, Francesco, et al.
Publicado: (2023)

Remote Homology Detection Identifies a Eukaryotic RPA DBD-C-like DNA Binding Domain as a Conserved Feature of Archaeal Rpa1-Like Proteins
por: MacNeill, Stuart A.
Publicado: (2021)

HARP preferentially co-purifies with RPA bound to DNA-PK and blocks RPA phosphorylation
por: Quan, Jinhua, et al.
Publicado: (2014)

Phosphorylated RPA recruits PALB2 to stalled DNA replication forks to facilitate fork recovery
por: Murphy, Anar K., et al.
Publicado: (2014)

Typhoid toxin exhausts the RPA response to DNA replication stress driving senescence and Salmonella infection
por: Ibler, Angela E. M., et al.
Publicado: (2019)

Correction to ‘RPA complexes in Caenorhabditis elegans meiosis; unique roles in replication, meiotic recombination and apoptosis’
por: Hefel, Adam, et al.
Publicado: (2021)

WASp modulates RPA function on single-stranded DNA in response to replication stress and DNA damage
por: Han, Seong-Su, et al.
Publicado: (2022)

Genomes of the autonomous parvovirus minute virus of mice induce replication stress through RPA exhaustion
por: Haubold, MegAnn K., et al.
Publicado: (2023)

Unravelling the clinicopathological and functional significance of replication protein A (RPA) heterotrimeric complex in breast cancers
por: Algethami, Mashael, et al.
Publicado: (2023)

Renormalized RPA at finite temperature
por: Avdeenkov, A V, et al.
Publicado: (1995)

Distinct roles for DNA-PK, ATM and ATR in RPA phosphorylation and checkpoint activation in response to replication stress
por: Liu, Shengqin, et al.
Publicado: (2012)

The Bloom syndrome complex senses RPA-coated single-stranded DNA to restart stalled replication forks
por: Shorrocks, Ann-Marie K., et al.
Publicado: (2021)

PHOSPHORYLATION-DEPENDENT ASSOCIATION OF WRN WITH RPA IS REQUIRED FOR RECOVERY OF REPLICATION FORKS STALLED AT SECONDARY DNA STRUCTURES
por: Noto, Alessandro, et al.
Publicado: (2023)

Evidence for direct contact between the RPA3 subunit of the human replication protein A and single-stranded DNA
por: Salas, Tonatiuh Romero, et al.
Publicado: (2009)

Functions of MutLα, Replication Protein A (RPA), and HMGB1 in 5′-Directed Mismatch Repair
por: Genschel, Jochen, et al.
Publicado: (2009)

A naturally occurring human RPA subunit homolog does not support DNA replication or cell-cycle progression
por: Haring, Stuart J., et al.
Publicado: (2010)

Extensive RPA2 hyperphosphorylation promotes apoptosis in response to DNA replication stress in CHK1 inhibited cells
por: Zuazua-Villar, Pedro, et al.
Publicado: (2015)

BRCA1-regulated RRM2 expression protects glioblastoma cells from endogenous replication stress and promotes tumorigenicity
por: Rasmussen, Rikke D., et al.
Publicado: (2016)

Glioblastoma Stem-Like Cells (GSCs) with Mesenchymal Signature: Lipid Profiles of Mobile Lipids Obtained with MRS before and after Radio/Chemical Treatments
por: Grande, Sveva, et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_h3rh0dnqlu9ap040fovb6la59f