Cargando…

Hsp90 Relieves Heat Stress-Induced Damage in Mouse Kidneys: Involvement of Antiapoptotic PKM2-AKT and Autophagic HIF-1α Signaling

Heat stress can particularly affect the kidney because of its high rate of adenosine triphosphate consumption. Competition between apoptosis and autophagy-mediated survival always exists in damaged tissue. And Hsp90 can enhance cellular protection to resist heat stress. However, the relationship bet...

Descripción completa

Detalles Bibliográficos
Autores principales:	Chen, Bixia, Yang, Bo, Zhu, Jie, Wu, Jiaxin, Sha, Junzhou, Sun, Jiarui, Bao, Endong, Zhang, Xiaohui
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2020
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7084842/ https://www.ncbi.nlm.nih.gov/pubmed/32121259 http://dx.doi.org/10.3390/ijms21051646

Ejemplares similares

Aspirin Enhances the Protection of Hsp90 from Heat-Stressed Injury in Cardiac Microvascular Endothelial Cells Through PI3K-Akt and PKM2 Pathways
por: Zhang, Xiaohui, et al.
Publicado: (2020)

Heat shock protein 90 relieves heat stress damage of myocardial cells by regulating Akt and PKM2 signaling in vivo
por: Zhang, Xiao-Hui, et al.
Publicado: (2020)

Transcriptomic investigation reveals toxic damage due to tilmicosin and potential resistance against tilmicosin in primary chicken myocardial cells
por: Zhang, Xiaohui, et al.
Publicado: (2020)

Extracellular Hsp90α Supports the ePKM2-GRP78-AKT Axis to Promote Tumor Metastasis
por: Zhang, Shaosen, et al.
Publicado: (2022)

Circulating heat shock protein 90 (Hsp90) and autoantibodies to Hsp90 are increased in patients with atopic dermatitis
por: Sitko, Krzysztof, et al.
Publicado: (2021)

Heat Shock Protein 90 (Hsp90) Expression and Breast Cancer
por: Zagouri, Flora, et al.
Publicado: (2012)

Traditional and Novel Mechanisms of Heat Shock Protein 90 (HSP90) Inhibition in Cancer Chemotherapy Including HSP90 Cleavage
por: Park, Sangkyu, et al.
Publicado: (2019)

Y‐632 inhibits heat shock protein 90 (Hsp90) function by disrupting the interaction between Hsp90 and Hsp70/Hsp90 organizing protein, and exerts antitumor activity in vitro and in vivo
por: Wang, Wenqian, et al.
Publicado: (2016)

Role of Heat Shock Proteins (HSP70 and HSP90) in Viral Infection
por: Lubkowska, Anna, et al.
Publicado: (2021)

Heat Shock Protein 90 (Hsp90) and Hsp70 as Potential Therapeutic Targets in Autoimmune Skin Diseases
por: Tukaj, Stefan, et al.
Publicado: (2022)

Potential role of heat shock protein 90 (Hsp90) in HIV uncoating
por: Joshi, Pheroze, et al.
Publicado: (2011)

Heat Shock Protein 90 (HSP90) and Her2 in Adenocarcinomas of the Esophagus
por: Slotta-Huspenina, Julia, et al.
Publicado: (2014)

Sensitization of multidrug-resistant cancer cells to Hsp90 inhibitors by NSAIDs-induced apoptotic and autophagic cell death
por: Moon, Hyun-Jung, et al.
Publicado: (2018)

Identification and Characterization of Three Heat Shock Protein 90 (Hsp90) Homologs in the Brown Planthopper
por: Chen, Xuan, et al.
Publicado: (2020)

Identification of Isoform-Selective Ligands for the Middle Domain of Heat Shock Protein 90 (Hsp90)
por: Mak, Oi Wei, et al.
Publicado: (2019)

Extracellular Heat Shock Protein-90 (eHsp90): Everything You Need to Know
por: Jay, Daniel, et al.
Publicado: (2022)

Silencing of heat shock protein 90 (hsp90): Effect on development and infectivity of Ichthyophthirius multifiliis
por: Saleh, Mona, et al.
Publicado: (2023)

Elevated expression of HSP90 and the antitumor effect of an HSP90 inhibitor via inactivation of the Akt/mTOR pathway in undifferentiated pleomorphic sarcoma
por: Bekki, Hirofumi, et al.
Publicado: (2015)

Rosemary Reduces Heat Stress by Inducing CRYAB and HSP70 Expression in Broiler Chickens
por: Tang, Shu, et al.
Publicado: (2018)

HSP90 promotes cell glycolysis, proliferation and inhibits apoptosis by regulating PKM2 abundance via Thr-328 phosphorylation in hepatocellular carcinoma
por: Xu, Qiuran, et al.
Publicado: (2017)

PKM2 Regulates HSP90-Mediated Stability of the IGF-1R Precursor Protein and Promotes Cancer Cell Survival during Hypoxia
por: Koo, Han, et al.
Publicado: (2021)

The effect of HIF-1α and PKM1 expression on acquisition of chemoresistance
por: Okazaki, Mitsuyoshi, et al.
Publicado: (2018)

Molecular docking and pharmacophore studies of heterocyclic compounds as Heat shock protein 90 (Hsp90) Inhibitors
por: Baby, Suby T, et al.
Publicado: (2016)

Overexpression of GmHsp90s, a Heat Shock Protein 90 (Hsp90) Gene Family Cloning from Soybean, Decrease Damage of Abiotic Stresses in Arabidopsis thaliana
por: Xu, Jinyan, et al.
Publicado: (2013)

HSP90 inhibits apoptosis and promotes growth by regulating HIF-1α abundance in hepatocellular carcinoma
por: Liu, Xin, et al.
Publicado: (2022)

Identification and Characterization of HSP90 Gene Family Reveals Involvement of HSP90, GRP94 and Not TRAP1 in Heat Stress Response in Chlamys farreri
por: Yu, Haitao, et al.
Publicado: (2021)

Quantification of Hsp90 availability reveals differential coupling to the heat shock response
por: Alford, Brian D., et al.
Publicado: (2018)

Targeting secreted heat shock protein-90alpha (Hsp90α) to prevent breast cancer progression
por: Zhao, Zhengwei, et al.
Publicado: (2010)

Heat Shock Protein 90 (Hsp90)-Inhibitor-Luminespib-Loaded-Protein-Based Nanoformulation for Cancer Therapy
por: K. Rochani, Ankit, et al.
Publicado: (2020)

PKM2, STAT3 and HIF-1α: The Warburg’s vicious circle
por: Demaria, Marco, et al.
Publicado: (2012)

PKM2 and HIF-1α regulation in prostate cancer cell lines
por: Hasan, Diya, et al.
Publicado: (2018)

FKBP51 plays an essential role in Akt ubiquitination that requires Hsp90 and PHLPP
por: Tufano, Martina, et al.
Publicado: (2023)

HSF-1, HIF-1and HSP90 expression on recombinant Pichia pastoris under fed-batch fermentation
por: Zepeda, Andrea B., et al.
Publicado: (2014)

Inhibition of Heat Shock proteins HSP90 and HSP70 induce oxidative stress, suppressing cotton fiber development
por: Sable, Anshulika, et al.
Publicado: (2018)

The Major Heat Shock Proteins, Hsp70 and Hsp90, in 2-Methoxyestradiol-Mediated Osteosarcoma Cell Death Model
por: Gorska-Ponikowska, Magdalena, et al.
Publicado: (2020)

Hsp-90 and the biology of nematodes
por: Him, Nik AIIN, et al.
Publicado: (2009)

Mechanisms of Hsp90 regulation
por: Prodromou, Chrisostomos
Publicado: (2016)

Regulatory Mechanisms of Hsp90
por: Prodromou, Chrisostomos
Publicado: (2017)

Inhibitors of HSP90 in melanoma
por: Mielczarek-Lewandowska, Aleksandra, et al.
Publicado: (2019)

Role of HSP90 in Cancer
por: Birbo, Bereket, et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_echr82fhcj4k35hfeirc7js0bk