The Biology of Prostaglandins and Their Role as a Target for Allergic Airway Disease Therapy

Prostaglandins (PGs) are a family of lipid compounds that are derived from arachidonic acid via the cyclooxygenase pathway, and consist of PGD(2), PGI(2), PGE(2), PGF(2), and thromboxane B(2). PGs signal through G-protein coupled receptors, and individual PGs affect allergic inflammation through dif...

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Detalles Bibliográficos
Autores principales: Lee, Kijeong, Lee, Sang Hag, Kim, Tae Hoon
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7084947/
https://www.ncbi.nlm.nih.gov/pubmed/32182661
http://dx.doi.org/10.3390/ijms21051851
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author Lee, Kijeong
Lee, Sang Hag
Kim, Tae Hoon
author_facet Lee, Kijeong
Lee, Sang Hag
Kim, Tae Hoon
author_sort Lee, Kijeong
collection PubMed
description Prostaglandins (PGs) are a family of lipid compounds that are derived from arachidonic acid via the cyclooxygenase pathway, and consist of PGD(2), PGI(2), PGE(2), PGF(2), and thromboxane B(2). PGs signal through G-protein coupled receptors, and individual PGs affect allergic inflammation through different mechanisms according to the receptors with which they are associated. In this review article, we have focused on the metabolism of the cyclooxygenase pathway, and the distinct biological effect of each PG type on various cell types involved in allergic airway diseases, including asthma, allergic rhinitis, nasal polyposis, and aspirin-exacerbated respiratory disease.
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spelling pubmed-70849472020-03-23 The Biology of Prostaglandins and Their Role as a Target for Allergic Airway Disease Therapy Lee, Kijeong Lee, Sang Hag Kim, Tae Hoon Int J Mol Sci Review Prostaglandins (PGs) are a family of lipid compounds that are derived from arachidonic acid via the cyclooxygenase pathway, and consist of PGD(2), PGI(2), PGE(2), PGF(2), and thromboxane B(2). PGs signal through G-protein coupled receptors, and individual PGs affect allergic inflammation through different mechanisms according to the receptors with which they are associated. In this review article, we have focused on the metabolism of the cyclooxygenase pathway, and the distinct biological effect of each PG type on various cell types involved in allergic airway diseases, including asthma, allergic rhinitis, nasal polyposis, and aspirin-exacerbated respiratory disease. MDPI 2020-03-08 /pmc/articles/PMC7084947/ /pubmed/32182661 http://dx.doi.org/10.3390/ijms21051851 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Lee, Kijeong
Lee, Sang Hag
Kim, Tae Hoon
The Biology of Prostaglandins and Their Role as a Target for Allergic Airway Disease Therapy
title The Biology of Prostaglandins and Their Role as a Target for Allergic Airway Disease Therapy
title_full The Biology of Prostaglandins and Their Role as a Target for Allergic Airway Disease Therapy
title_fullStr The Biology of Prostaglandins and Their Role as a Target for Allergic Airway Disease Therapy
title_full_unstemmed The Biology of Prostaglandins and Their Role as a Target for Allergic Airway Disease Therapy
title_short The Biology of Prostaglandins and Their Role as a Target for Allergic Airway Disease Therapy
title_sort biology of prostaglandins and their role as a target for allergic airway disease therapy
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7084947/
https://www.ncbi.nlm.nih.gov/pubmed/32182661
http://dx.doi.org/10.3390/ijms21051851
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