Antitumor Efficacy of Focused Ultrasound-MFL Nanoparticles Combination Therapy in Mouse Breast Cancer Xenografts

High doses of chemotherapy agents can cause adverse effects. To address this issue, drug-loaded vesicles with minimum drug loss, guided by an external element for precise delivery, are desired. Combinational therapy of both a focused ultrasound-induced drug delivery method and membrane fusogenic lip...

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Detalles Bibliográficos
Autores principales: Kim, Daehyun, Han, Junhee, Park, So Yeon, Kim, Heegon, Park, Ji-Ho, Lee, Hak Jong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7084991/
https://www.ncbi.nlm.nih.gov/pubmed/32121631
http://dx.doi.org/10.3390/ma13051099
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author Kim, Daehyun
Han, Junhee
Park, So Yeon
Kim, Heegon
Park, Ji-Ho
Lee, Hak Jong
author_facet Kim, Daehyun
Han, Junhee
Park, So Yeon
Kim, Heegon
Park, Ji-Ho
Lee, Hak Jong
author_sort Kim, Daehyun
collection PubMed
description High doses of chemotherapy agents can cause adverse effects. To address this issue, drug-loaded vesicles with minimum drug loss, guided by an external element for precise delivery, are desired. Combinational therapy of both a focused ultrasound-induced drug delivery method and membrane fusogenic liposomes (MFLs) as drug delivery vehicles can satisfy such premises. In this study, we confirmed that the use of a small quantity of docetaxel-loaded membrane fusogenic liposomes (DTX-MFL) with focused ultrasound can induce better antitumor response in a xenograft mouse model compared to conventional docetaxel monotherapy and DTX-MFL only.
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spelling pubmed-70849912020-03-23 Antitumor Efficacy of Focused Ultrasound-MFL Nanoparticles Combination Therapy in Mouse Breast Cancer Xenografts Kim, Daehyun Han, Junhee Park, So Yeon Kim, Heegon Park, Ji-Ho Lee, Hak Jong Materials (Basel) Article High doses of chemotherapy agents can cause adverse effects. To address this issue, drug-loaded vesicles with minimum drug loss, guided by an external element for precise delivery, are desired. Combinational therapy of both a focused ultrasound-induced drug delivery method and membrane fusogenic liposomes (MFLs) as drug delivery vehicles can satisfy such premises. In this study, we confirmed that the use of a small quantity of docetaxel-loaded membrane fusogenic liposomes (DTX-MFL) with focused ultrasound can induce better antitumor response in a xenograft mouse model compared to conventional docetaxel monotherapy and DTX-MFL only. MDPI 2020-03-02 /pmc/articles/PMC7084991/ /pubmed/32121631 http://dx.doi.org/10.3390/ma13051099 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Kim, Daehyun
Han, Junhee
Park, So Yeon
Kim, Heegon
Park, Ji-Ho
Lee, Hak Jong
Antitumor Efficacy of Focused Ultrasound-MFL Nanoparticles Combination Therapy in Mouse Breast Cancer Xenografts
title Antitumor Efficacy of Focused Ultrasound-MFL Nanoparticles Combination Therapy in Mouse Breast Cancer Xenografts
title_full Antitumor Efficacy of Focused Ultrasound-MFL Nanoparticles Combination Therapy in Mouse Breast Cancer Xenografts
title_fullStr Antitumor Efficacy of Focused Ultrasound-MFL Nanoparticles Combination Therapy in Mouse Breast Cancer Xenografts
title_full_unstemmed Antitumor Efficacy of Focused Ultrasound-MFL Nanoparticles Combination Therapy in Mouse Breast Cancer Xenografts
title_short Antitumor Efficacy of Focused Ultrasound-MFL Nanoparticles Combination Therapy in Mouse Breast Cancer Xenografts
title_sort antitumor efficacy of focused ultrasound-mfl nanoparticles combination therapy in mouse breast cancer xenografts
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7084991/
https://www.ncbi.nlm.nih.gov/pubmed/32121631
http://dx.doi.org/10.3390/ma13051099
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