Cargando…
The predictive study of the relation between elevated low-density lipoprotein cholesterol to high-density lipoprotein cholesterol ratio and mortality in peritoneal dialysis
BACKGROUND: The low-density lipoprotein cholesterol to high-density lipoprotein cholesterol (LDL-C/HDL-C) ratio constitutes a strong risk predictor of cardiovascular events. However, the association between this ratio and cardiovascular death in peritoneal dialysis (PD) patients is uncertain. The st...
Autores principales: | , , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2020
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7085176/ https://www.ncbi.nlm.nih.gov/pubmed/32199459 http://dx.doi.org/10.1186/s12944-020-01240-8 |
_version_ | 1783508891744600064 |
---|---|
author | Lin, Tong Xia, Xi Yu, Jing Qiu, Yagui Yi, Chunyan Lin, Jianxiong Mao, Haiping Yang, Xiao Huang, Fengxian |
author_facet | Lin, Tong Xia, Xi Yu, Jing Qiu, Yagui Yi, Chunyan Lin, Jianxiong Mao, Haiping Yang, Xiao Huang, Fengxian |
author_sort | Lin, Tong |
collection | PubMed |
description | BACKGROUND: The low-density lipoprotein cholesterol to high-density lipoprotein cholesterol (LDL-C/HDL-C) ratio constitutes a strong risk predictor of cardiovascular events. However, the association between this ratio and cardiovascular death in peritoneal dialysis (PD) patients is uncertain. The study aimed to investigate whether a high LDL-C/HDL-C ratio could predict both cardiovascular and all-cause mortalities in patients on PD. METHODS: A total of 1616 incident patients on PD included from January 1, 2006 to December 31, 2013 were followed up with until 31 December 2018 in this single-center prospective cohort study. Participants were divided into three categories according to LDL-C/HDL-C ratio tertile. The primary endpoint was cardiovascular mortality; the secondary endpoint was all-cause mortality. RESULTS: The mean age of the study cohort was 47.5 years and the mean body mass index (BMI) was 21.6 kg/m(2). During a median follow-up period of 47.6 months, 492 patients died, including 246 (50.0%) due to cardiovascular disease (CVD). A multivariate analysis revealed that the highest LDL-C/HDL-C ratio tertile was significantly associated with increased CVD mortality [hazard ratio (HR): 1.69, 95% CI: 1.24–2.29; P = 0.001] and all-cause mortality (HR: 1.46, 95% CI: 1.18–1.81; P = 0.001) relative to the lowest tertile. After adjusting for covariates, the HRs of cardiovascular and all-cause mortalities were 1.84 (95% CI: 1.25–2.71; P = 0.002) and 1.35 (95% CI: 1.03–1.77; P = 0.032). Subgroup analysis showed that the risk of CVD death rose with a higher LDL-C/HDL-C ratio among PD patients who were female, younger than 65 years old, without being malnourished (BMI ≥ 18.5 kg/m(2) or albumin ≥35 g/L), and with a history of diabetes or CVD, respectively. CONCLUSIONS: A high LDL-C/HDL-C ratio is an independent risk factor for both cardiovascular and all-cause mortalities among PD patients. |
format | Online Article Text |
id | pubmed-7085176 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-70851762020-03-23 The predictive study of the relation between elevated low-density lipoprotein cholesterol to high-density lipoprotein cholesterol ratio and mortality in peritoneal dialysis Lin, Tong Xia, Xi Yu, Jing Qiu, Yagui Yi, Chunyan Lin, Jianxiong Mao, Haiping Yang, Xiao Huang, Fengxian Lipids Health Dis Research BACKGROUND: The low-density lipoprotein cholesterol to high-density lipoprotein cholesterol (LDL-C/HDL-C) ratio constitutes a strong risk predictor of cardiovascular events. However, the association between this ratio and cardiovascular death in peritoneal dialysis (PD) patients is uncertain. The study aimed to investigate whether a high LDL-C/HDL-C ratio could predict both cardiovascular and all-cause mortalities in patients on PD. METHODS: A total of 1616 incident patients on PD included from January 1, 2006 to December 31, 2013 were followed up with until 31 December 2018 in this single-center prospective cohort study. Participants were divided into three categories according to LDL-C/HDL-C ratio tertile. The primary endpoint was cardiovascular mortality; the secondary endpoint was all-cause mortality. RESULTS: The mean age of the study cohort was 47.5 years and the mean body mass index (BMI) was 21.6 kg/m(2). During a median follow-up period of 47.6 months, 492 patients died, including 246 (50.0%) due to cardiovascular disease (CVD). A multivariate analysis revealed that the highest LDL-C/HDL-C ratio tertile was significantly associated with increased CVD mortality [hazard ratio (HR): 1.69, 95% CI: 1.24–2.29; P = 0.001] and all-cause mortality (HR: 1.46, 95% CI: 1.18–1.81; P = 0.001) relative to the lowest tertile. After adjusting for covariates, the HRs of cardiovascular and all-cause mortalities were 1.84 (95% CI: 1.25–2.71; P = 0.002) and 1.35 (95% CI: 1.03–1.77; P = 0.032). Subgroup analysis showed that the risk of CVD death rose with a higher LDL-C/HDL-C ratio among PD patients who were female, younger than 65 years old, without being malnourished (BMI ≥ 18.5 kg/m(2) or albumin ≥35 g/L), and with a history of diabetes or CVD, respectively. CONCLUSIONS: A high LDL-C/HDL-C ratio is an independent risk factor for both cardiovascular and all-cause mortalities among PD patients. BioMed Central 2020-03-21 /pmc/articles/PMC7085176/ /pubmed/32199459 http://dx.doi.org/10.1186/s12944-020-01240-8 Text en © The Author(s) 2020 Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data. |
spellingShingle | Research Lin, Tong Xia, Xi Yu, Jing Qiu, Yagui Yi, Chunyan Lin, Jianxiong Mao, Haiping Yang, Xiao Huang, Fengxian The predictive study of the relation between elevated low-density lipoprotein cholesterol to high-density lipoprotein cholesterol ratio and mortality in peritoneal dialysis |
title | The predictive study of the relation between elevated low-density lipoprotein cholesterol to high-density lipoprotein cholesterol ratio and mortality in peritoneal dialysis |
title_full | The predictive study of the relation between elevated low-density lipoprotein cholesterol to high-density lipoprotein cholesterol ratio and mortality in peritoneal dialysis |
title_fullStr | The predictive study of the relation between elevated low-density lipoprotein cholesterol to high-density lipoprotein cholesterol ratio and mortality in peritoneal dialysis |
title_full_unstemmed | The predictive study of the relation between elevated low-density lipoprotein cholesterol to high-density lipoprotein cholesterol ratio and mortality in peritoneal dialysis |
title_short | The predictive study of the relation between elevated low-density lipoprotein cholesterol to high-density lipoprotein cholesterol ratio and mortality in peritoneal dialysis |
title_sort | predictive study of the relation between elevated low-density lipoprotein cholesterol to high-density lipoprotein cholesterol ratio and mortality in peritoneal dialysis |
topic | Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7085176/ https://www.ncbi.nlm.nih.gov/pubmed/32199459 http://dx.doi.org/10.1186/s12944-020-01240-8 |
work_keys_str_mv | AT lintong thepredictivestudyoftherelationbetweenelevatedlowdensitylipoproteincholesteroltohighdensitylipoproteincholesterolratioandmortalityinperitonealdialysis AT xiaxi thepredictivestudyoftherelationbetweenelevatedlowdensitylipoproteincholesteroltohighdensitylipoproteincholesterolratioandmortalityinperitonealdialysis AT yujing thepredictivestudyoftherelationbetweenelevatedlowdensitylipoproteincholesteroltohighdensitylipoproteincholesterolratioandmortalityinperitonealdialysis AT qiuyagui thepredictivestudyoftherelationbetweenelevatedlowdensitylipoproteincholesteroltohighdensitylipoproteincholesterolratioandmortalityinperitonealdialysis AT yichunyan thepredictivestudyoftherelationbetweenelevatedlowdensitylipoproteincholesteroltohighdensitylipoproteincholesterolratioandmortalityinperitonealdialysis AT linjianxiong thepredictivestudyoftherelationbetweenelevatedlowdensitylipoproteincholesteroltohighdensitylipoproteincholesterolratioandmortalityinperitonealdialysis AT maohaiping thepredictivestudyoftherelationbetweenelevatedlowdensitylipoproteincholesteroltohighdensitylipoproteincholesterolratioandmortalityinperitonealdialysis AT yangxiao thepredictivestudyoftherelationbetweenelevatedlowdensitylipoproteincholesteroltohighdensitylipoproteincholesterolratioandmortalityinperitonealdialysis AT huangfengxian thepredictivestudyoftherelationbetweenelevatedlowdensitylipoproteincholesteroltohighdensitylipoproteincholesterolratioandmortalityinperitonealdialysis AT lintong predictivestudyoftherelationbetweenelevatedlowdensitylipoproteincholesteroltohighdensitylipoproteincholesterolratioandmortalityinperitonealdialysis AT xiaxi predictivestudyoftherelationbetweenelevatedlowdensitylipoproteincholesteroltohighdensitylipoproteincholesterolratioandmortalityinperitonealdialysis AT yujing predictivestudyoftherelationbetweenelevatedlowdensitylipoproteincholesteroltohighdensitylipoproteincholesterolratioandmortalityinperitonealdialysis AT qiuyagui predictivestudyoftherelationbetweenelevatedlowdensitylipoproteincholesteroltohighdensitylipoproteincholesterolratioandmortalityinperitonealdialysis AT yichunyan predictivestudyoftherelationbetweenelevatedlowdensitylipoproteincholesteroltohighdensitylipoproteincholesterolratioandmortalityinperitonealdialysis AT linjianxiong predictivestudyoftherelationbetweenelevatedlowdensitylipoproteincholesteroltohighdensitylipoproteincholesterolratioandmortalityinperitonealdialysis AT maohaiping predictivestudyoftherelationbetweenelevatedlowdensitylipoproteincholesteroltohighdensitylipoproteincholesterolratioandmortalityinperitonealdialysis AT yangxiao predictivestudyoftherelationbetweenelevatedlowdensitylipoproteincholesteroltohighdensitylipoproteincholesterolratioandmortalityinperitonealdialysis AT huangfengxian predictivestudyoftherelationbetweenelevatedlowdensitylipoproteincholesteroltohighdensitylipoproteincholesterolratioandmortalityinperitonealdialysis |