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Rare Genetic Variants of Large Effect Influence Risk of Type 1 Diabetes

Most replicated genetic determinants for type 1 diabetes are common (minor allele frequency [MAF] >5%). We aimed to identify novel rare or low-frequency (MAF <5%) single nucleotide polymorphisms with large effects on risk of type 1 diabetes. We undertook deep imputation of genotyped data follo...

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Detalles Bibliográficos
Autores principales:	Forgetta, Vincenzo, Manousaki, Despoina, Istomine, Roman, Ross, Stephanie, Tessier, Marie-Catherine, Marchand, Luc, Li, Min, Qu, Hui-Qi, Bradfield, Jonathan P., Grant, Struan F.A., Hakonarson, Hakon, Paterson, Andrew D., Piccirillo, Ciriaco, Polychronakos, Constantin, Richards, J. Brent
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Diabetes Association 2020
Materias:	Genetics/Genomes/Proteomics/Metabolomics
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7085253/ https://www.ncbi.nlm.nih.gov/pubmed/32005708 http://dx.doi.org/10.2337/db19-0831

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