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Traditional Chinese Medicine Containing Arsenic Treated MDS Patients Effectively through Regulating Aberrant Hypomethylation

Aberrant hypermethylation and hypomethylation both play important roles in myelodysplastic syndrome (MDS). Hypomethylating agents targeting hypermethylation have been employed for the MDS treatment, but the treatment effect is limited. Novel drugs for DNA hypomethylation-targeted therapy may be need...

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Autores principales: Zhou, Qing-bing, Zhu, Qian-zhe, Wang, Hong-zhi, Wang, De-xiu, Liu, Zheng-tang, Xu, Yong-gang, Hu, Xiao-mei, Ma, Rou, Xu, Feng-qin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7085376/
https://www.ncbi.nlm.nih.gov/pubmed/32215045
http://dx.doi.org/10.1155/2020/7469809
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author Zhou, Qing-bing
Zhu, Qian-zhe
Wang, Hong-zhi
Wang, De-xiu
Liu, Zheng-tang
Xu, Yong-gang
Hu, Xiao-mei
Ma, Rou
Xu, Feng-qin
author_facet Zhou, Qing-bing
Zhu, Qian-zhe
Wang, Hong-zhi
Wang, De-xiu
Liu, Zheng-tang
Xu, Yong-gang
Hu, Xiao-mei
Ma, Rou
Xu, Feng-qin
author_sort Zhou, Qing-bing
collection PubMed
description Aberrant hypermethylation and hypomethylation both play important roles in myelodysplastic syndrome (MDS). Hypomethylating agents targeting hypermethylation have been employed for the MDS treatment, but the treatment effect is limited. Novel drugs for DNA hypomethylation-targeted therapy may be needed to improve clinic efficacy for the treatment of MDS. Chinese medicine (CM) herbs have been used to treat MDS for many years in our hospital. However, the long-term treatment effect and mechanism remain unclear. In this study, all 135 patients received CM treatment for at least 36 months. The response rates for CM treatment were 81.53% (106/130) for hematological improvement in 130 MDS-RCMD patients and 80% (4/5) for bone marrow CR in 5 MDS-RAEB patients, respectively. The Human Methylation 850K BeadChip showed that 115 genes (50.88%) were aberrantly hypomethylated in 5 MDS patients compared with 3 healthy individuals. GO-analysis showed that these hypomethylated genes participated in many cancer-related biological functions and pathways. Furthermore, 60 genes were hypermethylated and the protein expression level of DNMT1 was significantly increased in the 5 MDS patients after 6 months of CM treatment. Our study suggests that CM can improve aberrant hypomethylation by increasing DNMT1 expression in MDS. The data support the clinical application of CM herbs containing arsenic as an innovative hypermethylation-inducing regimen for the treatment of MDS.
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spelling pubmed-70853762020-03-25 Traditional Chinese Medicine Containing Arsenic Treated MDS Patients Effectively through Regulating Aberrant Hypomethylation Zhou, Qing-bing Zhu, Qian-zhe Wang, Hong-zhi Wang, De-xiu Liu, Zheng-tang Xu, Yong-gang Hu, Xiao-mei Ma, Rou Xu, Feng-qin Evid Based Complement Alternat Med Research Article Aberrant hypermethylation and hypomethylation both play important roles in myelodysplastic syndrome (MDS). Hypomethylating agents targeting hypermethylation have been employed for the MDS treatment, but the treatment effect is limited. Novel drugs for DNA hypomethylation-targeted therapy may be needed to improve clinic efficacy for the treatment of MDS. Chinese medicine (CM) herbs have been used to treat MDS for many years in our hospital. However, the long-term treatment effect and mechanism remain unclear. In this study, all 135 patients received CM treatment for at least 36 months. The response rates for CM treatment were 81.53% (106/130) for hematological improvement in 130 MDS-RCMD patients and 80% (4/5) for bone marrow CR in 5 MDS-RAEB patients, respectively. The Human Methylation 850K BeadChip showed that 115 genes (50.88%) were aberrantly hypomethylated in 5 MDS patients compared with 3 healthy individuals. GO-analysis showed that these hypomethylated genes participated in many cancer-related biological functions and pathways. Furthermore, 60 genes were hypermethylated and the protein expression level of DNMT1 was significantly increased in the 5 MDS patients after 6 months of CM treatment. Our study suggests that CM can improve aberrant hypomethylation by increasing DNMT1 expression in MDS. The data support the clinical application of CM herbs containing arsenic as an innovative hypermethylation-inducing regimen for the treatment of MDS. Hindawi 2020-03-07 /pmc/articles/PMC7085376/ /pubmed/32215045 http://dx.doi.org/10.1155/2020/7469809 Text en Copyright © 2020 Qing-bing Zhou et al. http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Zhou, Qing-bing
Zhu, Qian-zhe
Wang, Hong-zhi
Wang, De-xiu
Liu, Zheng-tang
Xu, Yong-gang
Hu, Xiao-mei
Ma, Rou
Xu, Feng-qin
Traditional Chinese Medicine Containing Arsenic Treated MDS Patients Effectively through Regulating Aberrant Hypomethylation
title Traditional Chinese Medicine Containing Arsenic Treated MDS Patients Effectively through Regulating Aberrant Hypomethylation
title_full Traditional Chinese Medicine Containing Arsenic Treated MDS Patients Effectively through Regulating Aberrant Hypomethylation
title_fullStr Traditional Chinese Medicine Containing Arsenic Treated MDS Patients Effectively through Regulating Aberrant Hypomethylation
title_full_unstemmed Traditional Chinese Medicine Containing Arsenic Treated MDS Patients Effectively through Regulating Aberrant Hypomethylation
title_short Traditional Chinese Medicine Containing Arsenic Treated MDS Patients Effectively through Regulating Aberrant Hypomethylation
title_sort traditional chinese medicine containing arsenic treated mds patients effectively through regulating aberrant hypomethylation
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7085376/
https://www.ncbi.nlm.nih.gov/pubmed/32215045
http://dx.doi.org/10.1155/2020/7469809
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