CCAAT/Enhancer-Binding Protein β Mediates Oxygen-Induced Retinal Neovascularization via Retinal Vascular Damage and Vascular Endothelial Growth Factor

OBJECTIVE: To evaluate the role of CCAAT/enhancer-binding protein β (C/EBP β (C/EBP METHODS: Rats with OIR were exposed to alternating hypoxic and hyperopic conditions for 14 days. Then, the rats with OIR were assigned randomly to groups that received intravitreal injections of either shRNA lentivir...

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Autores principales: Li, Tingting, Cai, Xuan, Wang, Xiangning, Zhang, Xueyan, Zhang, Hui, Xu, Biwei, Li, Shiwei, Hu, Jianyan, Wu, Qiang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2020
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7085405/
https://www.ncbi.nlm.nih.gov/pubmed/32215270
http://dx.doi.org/10.1155/2020/2789209
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author Li, Tingting
Cai, Xuan
Wang, Xiangning
Zhang, Xueyan
Zhang, Hui
Xu, Biwei
Li, Shiwei
Hu, Jianyan
Wu, Qiang
author_facet Li, Tingting
Cai, Xuan
Wang, Xiangning
Zhang, Xueyan
Zhang, Hui
Xu, Biwei
Li, Shiwei
Hu, Jianyan
Wu, Qiang
author_sort Li, Tingting
collection PubMed
description OBJECTIVE: To evaluate the role of CCAAT/enhancer-binding protein β (C/EBP β (C/EBP METHODS: Rats with OIR were exposed to alternating hypoxic and hyperopic conditions for 14 days. Then, the rats with OIR were assigned randomly to groups that received intravitreal injections of either shRNA lentiviral particles targeting C/EBP β (C/EBP β (C/EBP β (C/EBP β (C/EBP β (C/EBP β (C/EBP RESULTS: In OIR rats, the expression levels of C/EBP β (C/EBP P < 0.01). The p-C/EBP β (C/EBP β (C/EBP β (C/EBP β (C/EBP β (C/EBP P < 0.01). The p-C/EBP β (C/EBP β (C/EBP β (C/EBP P < 0.01). The p-C/EBP CONCLUSIONS: C/EBP β shRNA inhibits RNV in OIR. A potential mechanism may be that the activity of C/EBP β increases with its overexpression, which in turn aggravates the amount of the retinal vascular damage and promotes transcription of VEGF. C/EBP β might be a new therapeutic target for preventing RNV.β (C/EBP β (C/EBP β (C/EBP
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spelling pubmed-70854052020-03-25 CCAAT/Enhancer-Binding Protein β Mediates Oxygen-Induced Retinal Neovascularization via Retinal Vascular Damage and Vascular Endothelial Growth Factor Li, Tingting Cai, Xuan Wang, Xiangning Zhang, Xueyan Zhang, Hui Xu, Biwei Li, Shiwei Hu, Jianyan Wu, Qiang J Diabetes Res Research Article OBJECTIVE: To evaluate the role of CCAAT/enhancer-binding protein β (C/EBP β (C/EBP METHODS: Rats with OIR were exposed to alternating hypoxic and hyperopic conditions for 14 days. Then, the rats with OIR were assigned randomly to groups that received intravitreal injections of either shRNA lentiviral particles targeting C/EBP β (C/EBP β (C/EBP β (C/EBP β (C/EBP β (C/EBP β (C/EBP RESULTS: In OIR rats, the expression levels of C/EBP β (C/EBP P < 0.01). The p-C/EBP β (C/EBP β (C/EBP β (C/EBP β (C/EBP β (C/EBP P < 0.01). The p-C/EBP β (C/EBP β (C/EBP β (C/EBP P < 0.01). The p-C/EBP CONCLUSIONS: C/EBP β shRNA inhibits RNV in OIR. A potential mechanism may be that the activity of C/EBP β increases with its overexpression, which in turn aggravates the amount of the retinal vascular damage and promotes transcription of VEGF. C/EBP β might be a new therapeutic target for preventing RNV.β (C/EBP β (C/EBP β (C/EBP Hindawi 2020-03-09 /pmc/articles/PMC7085405/ /pubmed/32215270 http://dx.doi.org/10.1155/2020/2789209 Text en Copyright © 2020 Tingting Li et al. http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Li, Tingting
Cai, Xuan
Wang, Xiangning
Zhang, Xueyan
Zhang, Hui
Xu, Biwei
Li, Shiwei
Hu, Jianyan
Wu, Qiang
CCAAT/Enhancer-Binding Protein β Mediates Oxygen-Induced Retinal Neovascularization via Retinal Vascular Damage and Vascular Endothelial Growth Factor
title CCAAT/Enhancer-Binding Protein β Mediates Oxygen-Induced Retinal Neovascularization via Retinal Vascular Damage and Vascular Endothelial Growth Factor
title_full CCAAT/Enhancer-Binding Protein β Mediates Oxygen-Induced Retinal Neovascularization via Retinal Vascular Damage and Vascular Endothelial Growth Factor
title_fullStr CCAAT/Enhancer-Binding Protein β Mediates Oxygen-Induced Retinal Neovascularization via Retinal Vascular Damage and Vascular Endothelial Growth Factor
title_full_unstemmed CCAAT/Enhancer-Binding Protein β Mediates Oxygen-Induced Retinal Neovascularization via Retinal Vascular Damage and Vascular Endothelial Growth Factor
title_short CCAAT/Enhancer-Binding Protein β Mediates Oxygen-Induced Retinal Neovascularization via Retinal Vascular Damage and Vascular Endothelial Growth Factor
title_sort ccaat/enhancer-binding protein β mediates oxygen-induced retinal neovascularization via retinal vascular damage and vascular endothelial growth factor
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7085405/
https://www.ncbi.nlm.nih.gov/pubmed/32215270
http://dx.doi.org/10.1155/2020/2789209
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