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Sensor-Integrated Microfluidic Approaches for Liquid Biopsies Applications in Early Detection of Cancer
Cancer represents one of the conditions with the most causes of death worldwide. Common methods for its diagnosis are based on tissue biopsies—the extraction of tissue from the primary tumor, which is used for its histological analysis. However, this technique represents a risk for the patient, alon...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7085501/ https://www.ncbi.nlm.nih.gov/pubmed/32121271 http://dx.doi.org/10.3390/s20051317 |
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author | Sierra, Jessica Marrugo-Ramírez, José Rodriguez-Trujillo, Romen Mir, Mònica Samitier, Josep |
author_facet | Sierra, Jessica Marrugo-Ramírez, José Rodriguez-Trujillo, Romen Mir, Mònica Samitier, Josep |
author_sort | Sierra, Jessica |
collection | PubMed |
description | Cancer represents one of the conditions with the most causes of death worldwide. Common methods for its diagnosis are based on tissue biopsies—the extraction of tissue from the primary tumor, which is used for its histological analysis. However, this technique represents a risk for the patient, along with being expensive and time-consuming and so it cannot be frequently used to follow the progress of the disease. Liquid biopsy is a new cancer diagnostic alternative, which allows the analysis of the molecular information of the solid tumors via a body fluid draw. This fluid-based diagnostic method displays relevant advantages, including its minimal invasiveness, lower risk, use as often as required, it can be analyzed with the use of microfluidic-based platforms with low consumption of reagent, and it does not require specialized personnel and expensive equipment for the diagnosis. In recent years, the integration of sensors in microfluidics lab-on-a-chip devices was performed for liquid biopsies applications, granting significant advantages in the separation and detection of circulating tumor nucleic acids (ctNAs), circulating tumor cells (CTCs) and exosomes. The improvements in isolation and detection technologies offer increasingly sensitive and selective equipment’s, and the integration in microfluidic devices provides a better characterization and analysis of these biomarkers. These fully integrated systems will facilitate the generation of fully automatized platforms at low-cost for compact cancer diagnosis systems at an early stage and for the prediction and prognosis of cancer treatment through the biomarkers for personalized tumor analysis. |
format | Online Article Text |
id | pubmed-7085501 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-70855012020-03-23 Sensor-Integrated Microfluidic Approaches for Liquid Biopsies Applications in Early Detection of Cancer Sierra, Jessica Marrugo-Ramírez, José Rodriguez-Trujillo, Romen Mir, Mònica Samitier, Josep Sensors (Basel) Review Cancer represents one of the conditions with the most causes of death worldwide. Common methods for its diagnosis are based on tissue biopsies—the extraction of tissue from the primary tumor, which is used for its histological analysis. However, this technique represents a risk for the patient, along with being expensive and time-consuming and so it cannot be frequently used to follow the progress of the disease. Liquid biopsy is a new cancer diagnostic alternative, which allows the analysis of the molecular information of the solid tumors via a body fluid draw. This fluid-based diagnostic method displays relevant advantages, including its minimal invasiveness, lower risk, use as often as required, it can be analyzed with the use of microfluidic-based platforms with low consumption of reagent, and it does not require specialized personnel and expensive equipment for the diagnosis. In recent years, the integration of sensors in microfluidics lab-on-a-chip devices was performed for liquid biopsies applications, granting significant advantages in the separation and detection of circulating tumor nucleic acids (ctNAs), circulating tumor cells (CTCs) and exosomes. The improvements in isolation and detection technologies offer increasingly sensitive and selective equipment’s, and the integration in microfluidic devices provides a better characterization and analysis of these biomarkers. These fully integrated systems will facilitate the generation of fully automatized platforms at low-cost for compact cancer diagnosis systems at an early stage and for the prediction and prognosis of cancer treatment through the biomarkers for personalized tumor analysis. MDPI 2020-02-28 /pmc/articles/PMC7085501/ /pubmed/32121271 http://dx.doi.org/10.3390/s20051317 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Sierra, Jessica Marrugo-Ramírez, José Rodriguez-Trujillo, Romen Mir, Mònica Samitier, Josep Sensor-Integrated Microfluidic Approaches for Liquid Biopsies Applications in Early Detection of Cancer |
title | Sensor-Integrated Microfluidic Approaches for Liquid Biopsies Applications in Early Detection of Cancer |
title_full | Sensor-Integrated Microfluidic Approaches for Liquid Biopsies Applications in Early Detection of Cancer |
title_fullStr | Sensor-Integrated Microfluidic Approaches for Liquid Biopsies Applications in Early Detection of Cancer |
title_full_unstemmed | Sensor-Integrated Microfluidic Approaches for Liquid Biopsies Applications in Early Detection of Cancer |
title_short | Sensor-Integrated Microfluidic Approaches for Liquid Biopsies Applications in Early Detection of Cancer |
title_sort | sensor-integrated microfluidic approaches for liquid biopsies applications in early detection of cancer |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7085501/ https://www.ncbi.nlm.nih.gov/pubmed/32121271 http://dx.doi.org/10.3390/s20051317 |
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