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Simulation Study for Designing a Dedicated Cardiac TOF-PET System
The development of dedicated positron emission tomography scanners is an active area of research, especially aiming at the improvement of lesion detection and in support of cancer treatment and management. Recently, dedicated Positron Emission Tomography (PET) systems with different configurations f...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7085583/ https://www.ncbi.nlm.nih.gov/pubmed/32121227 http://dx.doi.org/10.3390/s20051311 |
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author | Oliver, Sandra Moliner, Laura Ilisie, Víctor Benlloch, J.M. Rodríguez-Álvarez, M.J. |
author_facet | Oliver, Sandra Moliner, Laura Ilisie, Víctor Benlloch, J.M. Rodríguez-Álvarez, M.J. |
author_sort | Oliver, Sandra |
collection | PubMed |
description | The development of dedicated positron emission tomography scanners is an active area of research, especially aiming at the improvement of lesion detection and in support of cancer treatment and management. Recently, dedicated Positron Emission Tomography (PET) systems with different configurations for specific organs have been developed for improving detection effectiveness. Open geometries are always subject to distortion and artifacts in the reconstructed images. Therefore, the aim of this work is to determine the optimal geometry for a novel cardiac PET system that will be developed by our team, and determine the time resolution needed to achieve reasonable image quality for the chosen geometry. The proposed geometries consist of 36 modules. These modules are arranged in two sets of two plates, each one with different configurations. We performed Monte Carlo simulations with different TOF resolutions, in order to test the image quality improvement in each case. Our results show, as expected, that increasing TOF resolution reduces distortion and artifact effects. We can conclude that a TOF resolution of the order of 200 ps is needed to reduce the artifacts, to acceptable levels, generated in the simulated cardiac-PET open geometries. |
format | Online Article Text |
id | pubmed-7085583 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-70855832020-03-23 Simulation Study for Designing a Dedicated Cardiac TOF-PET System Oliver, Sandra Moliner, Laura Ilisie, Víctor Benlloch, J.M. Rodríguez-Álvarez, M.J. Sensors (Basel) Article The development of dedicated positron emission tomography scanners is an active area of research, especially aiming at the improvement of lesion detection and in support of cancer treatment and management. Recently, dedicated Positron Emission Tomography (PET) systems with different configurations for specific organs have been developed for improving detection effectiveness. Open geometries are always subject to distortion and artifacts in the reconstructed images. Therefore, the aim of this work is to determine the optimal geometry for a novel cardiac PET system that will be developed by our team, and determine the time resolution needed to achieve reasonable image quality for the chosen geometry. The proposed geometries consist of 36 modules. These modules are arranged in two sets of two plates, each one with different configurations. We performed Monte Carlo simulations with different TOF resolutions, in order to test the image quality improvement in each case. Our results show, as expected, that increasing TOF resolution reduces distortion and artifact effects. We can conclude that a TOF resolution of the order of 200 ps is needed to reduce the artifacts, to acceptable levels, generated in the simulated cardiac-PET open geometries. MDPI 2020-02-28 /pmc/articles/PMC7085583/ /pubmed/32121227 http://dx.doi.org/10.3390/s20051311 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Oliver, Sandra Moliner, Laura Ilisie, Víctor Benlloch, J.M. Rodríguez-Álvarez, M.J. Simulation Study for Designing a Dedicated Cardiac TOF-PET System |
title | Simulation Study for Designing a Dedicated Cardiac TOF-PET System |
title_full | Simulation Study for Designing a Dedicated Cardiac TOF-PET System |
title_fullStr | Simulation Study for Designing a Dedicated Cardiac TOF-PET System |
title_full_unstemmed | Simulation Study for Designing a Dedicated Cardiac TOF-PET System |
title_short | Simulation Study for Designing a Dedicated Cardiac TOF-PET System |
title_sort | simulation study for designing a dedicated cardiac tof-pet system |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7085583/ https://www.ncbi.nlm.nih.gov/pubmed/32121227 http://dx.doi.org/10.3390/s20051311 |
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