Cargando…

Simulation Study for Designing a Dedicated Cardiac TOF-PET System

The development of dedicated positron emission tomography scanners is an active area of research, especially aiming at the improvement of lesion detection and in support of cancer treatment and management. Recently, dedicated Positron Emission Tomography (PET) systems with different configurations f...

Descripción completa

Detalles Bibliográficos
Autores principales: Oliver, Sandra, Moliner, Laura, Ilisie, Víctor, Benlloch, J.M., Rodríguez-Álvarez, M.J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7085583/
https://www.ncbi.nlm.nih.gov/pubmed/32121227
http://dx.doi.org/10.3390/s20051311
_version_ 1783508965049499648
author Oliver, Sandra
Moliner, Laura
Ilisie, Víctor
Benlloch, J.M.
Rodríguez-Álvarez, M.J.
author_facet Oliver, Sandra
Moliner, Laura
Ilisie, Víctor
Benlloch, J.M.
Rodríguez-Álvarez, M.J.
author_sort Oliver, Sandra
collection PubMed
description The development of dedicated positron emission tomography scanners is an active area of research, especially aiming at the improvement of lesion detection and in support of cancer treatment and management. Recently, dedicated Positron Emission Tomography (PET) systems with different configurations for specific organs have been developed for improving detection effectiveness. Open geometries are always subject to distortion and artifacts in the reconstructed images. Therefore, the aim of this work is to determine the optimal geometry for a novel cardiac PET system that will be developed by our team, and determine the time resolution needed to achieve reasonable image quality for the chosen geometry. The proposed geometries consist of 36 modules. These modules are arranged in two sets of two plates, each one with different configurations. We performed Monte Carlo simulations with different TOF resolutions, in order to test the image quality improvement in each case. Our results show, as expected, that increasing TOF resolution reduces distortion and artifact effects. We can conclude that a TOF resolution of the order of 200 ps is needed to reduce the artifacts, to acceptable levels, generated in the simulated cardiac-PET open geometries.
format Online
Article
Text
id pubmed-7085583
institution National Center for Biotechnology Information
language English
publishDate 2020
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-70855832020-03-23 Simulation Study for Designing a Dedicated Cardiac TOF-PET System Oliver, Sandra Moliner, Laura Ilisie, Víctor Benlloch, J.M. Rodríguez-Álvarez, M.J. Sensors (Basel) Article The development of dedicated positron emission tomography scanners is an active area of research, especially aiming at the improvement of lesion detection and in support of cancer treatment and management. Recently, dedicated Positron Emission Tomography (PET) systems with different configurations for specific organs have been developed for improving detection effectiveness. Open geometries are always subject to distortion and artifacts in the reconstructed images. Therefore, the aim of this work is to determine the optimal geometry for a novel cardiac PET system that will be developed by our team, and determine the time resolution needed to achieve reasonable image quality for the chosen geometry. The proposed geometries consist of 36 modules. These modules are arranged in two sets of two plates, each one with different configurations. We performed Monte Carlo simulations with different TOF resolutions, in order to test the image quality improvement in each case. Our results show, as expected, that increasing TOF resolution reduces distortion and artifact effects. We can conclude that a TOF resolution of the order of 200 ps is needed to reduce the artifacts, to acceptable levels, generated in the simulated cardiac-PET open geometries. MDPI 2020-02-28 /pmc/articles/PMC7085583/ /pubmed/32121227 http://dx.doi.org/10.3390/s20051311 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Oliver, Sandra
Moliner, Laura
Ilisie, Víctor
Benlloch, J.M.
Rodríguez-Álvarez, M.J.
Simulation Study for Designing a Dedicated Cardiac TOF-PET System
title Simulation Study for Designing a Dedicated Cardiac TOF-PET System
title_full Simulation Study for Designing a Dedicated Cardiac TOF-PET System
title_fullStr Simulation Study for Designing a Dedicated Cardiac TOF-PET System
title_full_unstemmed Simulation Study for Designing a Dedicated Cardiac TOF-PET System
title_short Simulation Study for Designing a Dedicated Cardiac TOF-PET System
title_sort simulation study for designing a dedicated cardiac tof-pet system
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7085583/
https://www.ncbi.nlm.nih.gov/pubmed/32121227
http://dx.doi.org/10.3390/s20051311
work_keys_str_mv AT oliversandra simulationstudyfordesigningadedicatedcardiactofpetsystem
AT molinerlaura simulationstudyfordesigningadedicatedcardiactofpetsystem
AT ilisievictor simulationstudyfordesigningadedicatedcardiactofpetsystem
AT benllochjm simulationstudyfordesigningadedicatedcardiactofpetsystem
AT rodriguezalvarezmj simulationstudyfordesigningadedicatedcardiactofpetsystem