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Advances in Sonothrombolysis Techniques Using Piezoelectric Transducers

One of the great advancements in the applications of piezoelectric materials is the application for therapeutic medical ultrasound for sonothrombolysis. Sonothrombolysis is a promising ultrasound based technique to treat blood clots compared to conventional thrombolytic treatments or mechanical thro...

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Detalles Bibliográficos
Autores principales: Goel, Leela, Jiang, Xiaoning
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7085655/
https://www.ncbi.nlm.nih.gov/pubmed/32120902
http://dx.doi.org/10.3390/s20051288
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author Goel, Leela
Jiang, Xiaoning
author_facet Goel, Leela
Jiang, Xiaoning
author_sort Goel, Leela
collection PubMed
description One of the great advancements in the applications of piezoelectric materials is the application for therapeutic medical ultrasound for sonothrombolysis. Sonothrombolysis is a promising ultrasound based technique to treat blood clots compared to conventional thrombolytic treatments or mechanical thrombectomy. Recent clinical trials using transcranial Doppler ultrasound, microbubble mediated sonothrombolysis, and catheter directed sonothrombolysis have shown promise. However, these conventional sonothrombolysis techniques still pose clinical safety limitations, preventing their application for standard of care. Recent advances in sonothrombolysis techniques including targeted and drug loaded microbubbles, phase change nanodroplets, high intensity focused ultrasound, histotripsy, and improved intravascular transducers, address some of the limitations of conventional sonothrombolysis treatments. Here, we review the strengths and limitations of these latest pre-clincial advancements for sonothrombolysis and their potential to improve clinical blood clot treatments.
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spelling pubmed-70856552020-04-21 Advances in Sonothrombolysis Techniques Using Piezoelectric Transducers Goel, Leela Jiang, Xiaoning Sensors (Basel) Review One of the great advancements in the applications of piezoelectric materials is the application for therapeutic medical ultrasound for sonothrombolysis. Sonothrombolysis is a promising ultrasound based technique to treat blood clots compared to conventional thrombolytic treatments or mechanical thrombectomy. Recent clinical trials using transcranial Doppler ultrasound, microbubble mediated sonothrombolysis, and catheter directed sonothrombolysis have shown promise. However, these conventional sonothrombolysis techniques still pose clinical safety limitations, preventing their application for standard of care. Recent advances in sonothrombolysis techniques including targeted and drug loaded microbubbles, phase change nanodroplets, high intensity focused ultrasound, histotripsy, and improved intravascular transducers, address some of the limitations of conventional sonothrombolysis treatments. Here, we review the strengths and limitations of these latest pre-clincial advancements for sonothrombolysis and their potential to improve clinical blood clot treatments. MDPI 2020-02-27 /pmc/articles/PMC7085655/ /pubmed/32120902 http://dx.doi.org/10.3390/s20051288 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Goel, Leela
Jiang, Xiaoning
Advances in Sonothrombolysis Techniques Using Piezoelectric Transducers
title Advances in Sonothrombolysis Techniques Using Piezoelectric Transducers
title_full Advances in Sonothrombolysis Techniques Using Piezoelectric Transducers
title_fullStr Advances in Sonothrombolysis Techniques Using Piezoelectric Transducers
title_full_unstemmed Advances in Sonothrombolysis Techniques Using Piezoelectric Transducers
title_short Advances in Sonothrombolysis Techniques Using Piezoelectric Transducers
title_sort advances in sonothrombolysis techniques using piezoelectric transducers
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7085655/
https://www.ncbi.nlm.nih.gov/pubmed/32120902
http://dx.doi.org/10.3390/s20051288
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