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Nanostructured Chemoresistive Sensors for Oncological Screening and Tumor Markers Tracking: Single Sensor Approach Applications on Human Blood and Cell Samples

Preventive screening does not only allow to preemptively intervene on pathologies before they can harm the host; but also to reduce the costs of the intervention itself; boosting the efficiency of the NHS (National Health System) by saving resources for other purposes. To improve technology advancem...

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Autores principales: Landini, Nicolò, Anania, Gabriele, Astolfi, Michele, Fabbri, Barbara, Guidi, Vincenzo, Rispoli, Giorgio, Valt, Matteo, Zonta, Giulia, Malagù, Cesare
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7085750/
https://www.ncbi.nlm.nih.gov/pubmed/32143491
http://dx.doi.org/10.3390/s20051411
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author Landini, Nicolò
Anania, Gabriele
Astolfi, Michele
Fabbri, Barbara
Guidi, Vincenzo
Rispoli, Giorgio
Valt, Matteo
Zonta, Giulia
Malagù, Cesare
author_facet Landini, Nicolò
Anania, Gabriele
Astolfi, Michele
Fabbri, Barbara
Guidi, Vincenzo
Rispoli, Giorgio
Valt, Matteo
Zonta, Giulia
Malagù, Cesare
author_sort Landini, Nicolò
collection PubMed
description Preventive screening does not only allow to preemptively intervene on pathologies before they can harm the host; but also to reduce the costs of the intervention itself; boosting the efficiency of the NHS (National Health System) by saving resources for other purposes. To improve technology advancements in this field; user-friendly yet low-cost devices are required; and various applications for gas sensors have been tested and proved reliable in past studies. In this work; cell cultures and blood samples have been studied; using nanostructured chemoresistive sensors; to both verify if this technology can reliably detect tumor markers; and if correlations between responses from tumor line metabolites and the screening outcomes on human specimens could be observed. The results showed how sensors responded differently to the emanations from healthy and mutant (for cells) or tumor affected (for blood) samples, and how those results were consistent between them, since the tumoral specimens had higher responses compared to the ones of their healthy counterparts. Even though the patterns in the responses require a bigger population to be defined properly; it appeared that the different macro-groups between the same kind of samples are distinguishable from some of the sensors chosen in the study; giving promising outcomes for further research.
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spelling pubmed-70857502020-03-25 Nanostructured Chemoresistive Sensors for Oncological Screening and Tumor Markers Tracking: Single Sensor Approach Applications on Human Blood and Cell Samples Landini, Nicolò Anania, Gabriele Astolfi, Michele Fabbri, Barbara Guidi, Vincenzo Rispoli, Giorgio Valt, Matteo Zonta, Giulia Malagù, Cesare Sensors (Basel) Article Preventive screening does not only allow to preemptively intervene on pathologies before they can harm the host; but also to reduce the costs of the intervention itself; boosting the efficiency of the NHS (National Health System) by saving resources for other purposes. To improve technology advancements in this field; user-friendly yet low-cost devices are required; and various applications for gas sensors have been tested and proved reliable in past studies. In this work; cell cultures and blood samples have been studied; using nanostructured chemoresistive sensors; to both verify if this technology can reliably detect tumor markers; and if correlations between responses from tumor line metabolites and the screening outcomes on human specimens could be observed. The results showed how sensors responded differently to the emanations from healthy and mutant (for cells) or tumor affected (for blood) samples, and how those results were consistent between them, since the tumoral specimens had higher responses compared to the ones of their healthy counterparts. Even though the patterns in the responses require a bigger population to be defined properly; it appeared that the different macro-groups between the same kind of samples are distinguishable from some of the sensors chosen in the study; giving promising outcomes for further research. MDPI 2020-03-04 /pmc/articles/PMC7085750/ /pubmed/32143491 http://dx.doi.org/10.3390/s20051411 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Landini, Nicolò
Anania, Gabriele
Astolfi, Michele
Fabbri, Barbara
Guidi, Vincenzo
Rispoli, Giorgio
Valt, Matteo
Zonta, Giulia
Malagù, Cesare
Nanostructured Chemoresistive Sensors for Oncological Screening and Tumor Markers Tracking: Single Sensor Approach Applications on Human Blood and Cell Samples
title Nanostructured Chemoresistive Sensors for Oncological Screening and Tumor Markers Tracking: Single Sensor Approach Applications on Human Blood and Cell Samples
title_full Nanostructured Chemoresistive Sensors for Oncological Screening and Tumor Markers Tracking: Single Sensor Approach Applications on Human Blood and Cell Samples
title_fullStr Nanostructured Chemoresistive Sensors for Oncological Screening and Tumor Markers Tracking: Single Sensor Approach Applications on Human Blood and Cell Samples
title_full_unstemmed Nanostructured Chemoresistive Sensors for Oncological Screening and Tumor Markers Tracking: Single Sensor Approach Applications on Human Blood and Cell Samples
title_short Nanostructured Chemoresistive Sensors for Oncological Screening and Tumor Markers Tracking: Single Sensor Approach Applications on Human Blood and Cell Samples
title_sort nanostructured chemoresistive sensors for oncological screening and tumor markers tracking: single sensor approach applications on human blood and cell samples
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7085750/
https://www.ncbi.nlm.nih.gov/pubmed/32143491
http://dx.doi.org/10.3390/s20051411
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