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I-a(low)CD11b(high) DC Regulates the Immune Response in the Eyes of Experimental Autoimmune Uveitis
Regulatory dendritic cells (DC(reg)) have been reported to be a negative regulator in the immune response. These cells are widely distributed in the liver, spleen, and lung. However, the status and function of DC(reg) in the eyes and disease are still not very clear. Herein, we found that the number...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Hindawi
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7085850/ https://www.ncbi.nlm.nih.gov/pubmed/32256194 http://dx.doi.org/10.1155/2020/6947482 |
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author | Zhao, Yu Wang, Jingwen Min, Zhang Peng, Li Qi, Shuhong Lin, Wei |
author_facet | Zhao, Yu Wang, Jingwen Min, Zhang Peng, Li Qi, Shuhong Lin, Wei |
author_sort | Zhao, Yu |
collection | PubMed |
description | Regulatory dendritic cells (DC(reg)) have been reported to be a negative regulator in the immune response. These cells are widely distributed in the liver, spleen, and lung. However, the status and function of DC(reg) in the eyes and disease are still not very clear. Herein, we found that the number of I-a(low)CD11b(high) DC increased in the eye and spleen at the recovery stage of experimental autoimmune uveitis (EAU), which is a mouse model for autoimmune uveitis. These cells expressed lower levels of CD80, CD86, and CD54 than the mature DCs and expressed interleukin 10 (IL-10), indoleamine 2,3-dioxygenase (IDO), and transforming growth factor beta (TGF-β) as well. Moreover, these DC(reg) can regulate the development of EAU by promoting CD4(+)CD25(+)Foxp3(+) regulatory T cells. The increased interferon-gamma (IFN-γ) in the aqueous humor of EAU participates in inducing DC(reg) to alleviate the symptom of EAU. Furthermore, DC(reg) was found to exist in the eyes of normal mice. Aqueous humor, containing a certain concentration of IL-10, TGF-β, prostaglandin E2 (PGE2), IDO, and nitric oxide (NO), induced the tolerance of DC(reg) in normal eyes. It can be concluded that DC(reg) exists in the eyes and plays a protective role in inflamed eyes. These DC(reg) induced by IFN-γ might be used as a strategy to develop therapy for EAU management. |
format | Online Article Text |
id | pubmed-7085850 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | Hindawi |
record_format | MEDLINE/PubMed |
spelling | pubmed-70858502020-04-03 I-a(low)CD11b(high) DC Regulates the Immune Response in the Eyes of Experimental Autoimmune Uveitis Zhao, Yu Wang, Jingwen Min, Zhang Peng, Li Qi, Shuhong Lin, Wei Mediators Inflamm Research Article Regulatory dendritic cells (DC(reg)) have been reported to be a negative regulator in the immune response. These cells are widely distributed in the liver, spleen, and lung. However, the status and function of DC(reg) in the eyes and disease are still not very clear. Herein, we found that the number of I-a(low)CD11b(high) DC increased in the eye and spleen at the recovery stage of experimental autoimmune uveitis (EAU), which is a mouse model for autoimmune uveitis. These cells expressed lower levels of CD80, CD86, and CD54 than the mature DCs and expressed interleukin 10 (IL-10), indoleamine 2,3-dioxygenase (IDO), and transforming growth factor beta (TGF-β) as well. Moreover, these DC(reg) can regulate the development of EAU by promoting CD4(+)CD25(+)Foxp3(+) regulatory T cells. The increased interferon-gamma (IFN-γ) in the aqueous humor of EAU participates in inducing DC(reg) to alleviate the symptom of EAU. Furthermore, DC(reg) was found to exist in the eyes of normal mice. Aqueous humor, containing a certain concentration of IL-10, TGF-β, prostaglandin E2 (PGE2), IDO, and nitric oxide (NO), induced the tolerance of DC(reg) in normal eyes. It can be concluded that DC(reg) exists in the eyes and plays a protective role in inflamed eyes. These DC(reg) induced by IFN-γ might be used as a strategy to develop therapy for EAU management. Hindawi 2020-03-10 /pmc/articles/PMC7085850/ /pubmed/32256194 http://dx.doi.org/10.1155/2020/6947482 Text en Copyright © 2020 Yu Zhao et al. http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Research Article Zhao, Yu Wang, Jingwen Min, Zhang Peng, Li Qi, Shuhong Lin, Wei I-a(low)CD11b(high) DC Regulates the Immune Response in the Eyes of Experimental Autoimmune Uveitis |
title | I-a(low)CD11b(high) DC Regulates the Immune Response in the Eyes of Experimental Autoimmune Uveitis |
title_full | I-a(low)CD11b(high) DC Regulates the Immune Response in the Eyes of Experimental Autoimmune Uveitis |
title_fullStr | I-a(low)CD11b(high) DC Regulates the Immune Response in the Eyes of Experimental Autoimmune Uveitis |
title_full_unstemmed | I-a(low)CD11b(high) DC Regulates the Immune Response in the Eyes of Experimental Autoimmune Uveitis |
title_short | I-a(low)CD11b(high) DC Regulates the Immune Response in the Eyes of Experimental Autoimmune Uveitis |
title_sort | i-a(low)cd11b(high) dc regulates the immune response in the eyes of experimental autoimmune uveitis |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7085850/ https://www.ncbi.nlm.nih.gov/pubmed/32256194 http://dx.doi.org/10.1155/2020/6947482 |
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