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Different Incidence of Early-Onset Gastric Carcinoma Depending on Ethnicity: Preliminary Results of a Hospital in Liangshan

BACKGROUND: In China, the incidence of cancer has significantly decreased over the last two decades. In contrast, the incidence of gastric carcinoma (GC) has risen in young patients. METHODS: We reevaluated the histopathological results of 4,353 endoscopic gastroscopies from the Department of Pathol...

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Autores principales: Li, Shen, Rexin, Peter, Qin, Zhang, Changbo, Chen, Guanghui, Chen, Luyao, Wang, Voelker, Hans-Ullrich, Stauch, Gerhard
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7085875/
https://www.ncbi.nlm.nih.gov/pubmed/32231466
http://dx.doi.org/10.1155/2020/6845413
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author Li, Shen
Rexin, Peter
Qin, Zhang
Changbo, Chen
Guanghui, Chen
Luyao, Wang
Voelker, Hans-Ullrich
Stauch, Gerhard
author_facet Li, Shen
Rexin, Peter
Qin, Zhang
Changbo, Chen
Guanghui, Chen
Luyao, Wang
Voelker, Hans-Ullrich
Stauch, Gerhard
author_sort Li, Shen
collection PubMed
description BACKGROUND: In China, the incidence of cancer has significantly decreased over the last two decades. In contrast, the incidence of gastric carcinoma (GC) has risen in young patients. METHODS: We reevaluated the histopathological results of 4,353 endoscopic gastroscopies from the Department of Pathology at No 1 Hospital of Liangshan. The ethnic groups Han and Yi were almost equally distributed in this cohort. Over a five-year period, 1407 GC were diagnosed. RESULTS: In 171 of these cases (12%), the patients were ≤40 years old (early-onset GC, EOGC). Out of this cohort, 9 patients were aged ≤25 years. 54% of these patients were male and showed marked predominance (92%) of the Yi-minority. Using the classification of Lauren, 103 GC (60%) were of diffuse type, 27 (16%) of intestinal type, and 41 (24%) of mixed type. In the remaining 1,236 cases of patients ≥41 years (88%), 1,014 patients (82%) belonged to the Yi-minority. Helicobacter pylori (HP) were found in 46% of all cases. Familial clustering was found in 14 patients (18%; in first degree relatives, 12%, and in second degree relatives, 6%). Follow-up was not possible. CONCLUSION: This study demonstrates the unequal manifestation of EOGC within the two ethnic groups of Han and Yi. However, familial clustering was infrequent. Further investigations are necessary to discover relevant risk factors apart from hereditary predisposition.
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spelling pubmed-70858752020-03-30 Different Incidence of Early-Onset Gastric Carcinoma Depending on Ethnicity: Preliminary Results of a Hospital in Liangshan Li, Shen Rexin, Peter Qin, Zhang Changbo, Chen Guanghui, Chen Luyao, Wang Voelker, Hans-Ullrich Stauch, Gerhard ScientificWorldJournal Research Article BACKGROUND: In China, the incidence of cancer has significantly decreased over the last two decades. In contrast, the incidence of gastric carcinoma (GC) has risen in young patients. METHODS: We reevaluated the histopathological results of 4,353 endoscopic gastroscopies from the Department of Pathology at No 1 Hospital of Liangshan. The ethnic groups Han and Yi were almost equally distributed in this cohort. Over a five-year period, 1407 GC were diagnosed. RESULTS: In 171 of these cases (12%), the patients were ≤40 years old (early-onset GC, EOGC). Out of this cohort, 9 patients were aged ≤25 years. 54% of these patients were male and showed marked predominance (92%) of the Yi-minority. Using the classification of Lauren, 103 GC (60%) were of diffuse type, 27 (16%) of intestinal type, and 41 (24%) of mixed type. In the remaining 1,236 cases of patients ≥41 years (88%), 1,014 patients (82%) belonged to the Yi-minority. Helicobacter pylori (HP) were found in 46% of all cases. Familial clustering was found in 14 patients (18%; in first degree relatives, 12%, and in second degree relatives, 6%). Follow-up was not possible. CONCLUSION: This study demonstrates the unequal manifestation of EOGC within the two ethnic groups of Han and Yi. However, familial clustering was infrequent. Further investigations are necessary to discover relevant risk factors apart from hereditary predisposition. Hindawi 2020-03-10 /pmc/articles/PMC7085875/ /pubmed/32231466 http://dx.doi.org/10.1155/2020/6845413 Text en Copyright © 2020 Shen Li et al. http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Li, Shen
Rexin, Peter
Qin, Zhang
Changbo, Chen
Guanghui, Chen
Luyao, Wang
Voelker, Hans-Ullrich
Stauch, Gerhard
Different Incidence of Early-Onset Gastric Carcinoma Depending on Ethnicity: Preliminary Results of a Hospital in Liangshan
title Different Incidence of Early-Onset Gastric Carcinoma Depending on Ethnicity: Preliminary Results of a Hospital in Liangshan
title_full Different Incidence of Early-Onset Gastric Carcinoma Depending on Ethnicity: Preliminary Results of a Hospital in Liangshan
title_fullStr Different Incidence of Early-Onset Gastric Carcinoma Depending on Ethnicity: Preliminary Results of a Hospital in Liangshan
title_full_unstemmed Different Incidence of Early-Onset Gastric Carcinoma Depending on Ethnicity: Preliminary Results of a Hospital in Liangshan
title_short Different Incidence of Early-Onset Gastric Carcinoma Depending on Ethnicity: Preliminary Results of a Hospital in Liangshan
title_sort different incidence of early-onset gastric carcinoma depending on ethnicity: preliminary results of a hospital in liangshan
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7085875/
https://www.ncbi.nlm.nih.gov/pubmed/32231466
http://dx.doi.org/10.1155/2020/6845413
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