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Precommissural and postcommissural fornix microstructure in healthy aging and cognition
The fornix is a key tract of the hippocampal formation, whose status is presumed to contribute to age-related cognitive decline. The precommissural and postcommissural fornix subdivisions form respective basal forebrain/frontal and diencephalic networks that may differentially affect aging and cogni...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
SAGE Publications
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7085915/ https://www.ncbi.nlm.nih.gov/pubmed/32219177 http://dx.doi.org/10.1177/2398212819899316 |
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author | Coad, Bethany M. Craig, Emma Louch, Rebecca Aggleton, John P. Vann, Seralynne D. Metzler-Baddeley, Claudia |
author_facet | Coad, Bethany M. Craig, Emma Louch, Rebecca Aggleton, John P. Vann, Seralynne D. Metzler-Baddeley, Claudia |
author_sort | Coad, Bethany M. |
collection | PubMed |
description | The fornix is a key tract of the hippocampal formation, whose status is presumed to contribute to age-related cognitive decline. The precommissural and postcommissural fornix subdivisions form respective basal forebrain/frontal and diencephalic networks that may differentially affect aging and cognition. We employed multi-parametric magnetic resonance imaging (MRI) including neurite orientation density and dispersion imaging, quantitative magnetization transfer (qMT), and T(1)-relaxometry MRI to investigate the microstructural properties of these fornix subdivisions and their relationship with aging and cognition in 149 asymptomatic participants (38–71 years). Aging was associated with increased free water signal and reductions in myelin-sensitive R(1) and qMT indices but no apparent axon density differences in both precommissural and postcommissural fibers. Precommissural relative to postcommissural fibers showed a distinct microstructural pattern characterised by larger free water signal and axon orientation dispersion, with lower apparent myelin and axon density. Furthermore, differences in postcommissural microstructure were related to performance differences in object-location paired-associate learning. These results provide novel in vivo neuroimaging evidence for distinct microstructural properties of precommissural and postcommissural fibers that are consistent with their anatomy as found in axonal tracer studies, as well as for a contribution of postcommissural fibers to the learning of spatial configurations. |
format | Online Article Text |
id | pubmed-7085915 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | SAGE Publications |
record_format | MEDLINE/PubMed |
spelling | pubmed-70859152020-03-26 Precommissural and postcommissural fornix microstructure in healthy aging and cognition Coad, Bethany M. Craig, Emma Louch, Rebecca Aggleton, John P. Vann, Seralynne D. Metzler-Baddeley, Claudia Brain Neurosci Adv Research Paper The fornix is a key tract of the hippocampal formation, whose status is presumed to contribute to age-related cognitive decline. The precommissural and postcommissural fornix subdivisions form respective basal forebrain/frontal and diencephalic networks that may differentially affect aging and cognition. We employed multi-parametric magnetic resonance imaging (MRI) including neurite orientation density and dispersion imaging, quantitative magnetization transfer (qMT), and T(1)-relaxometry MRI to investigate the microstructural properties of these fornix subdivisions and their relationship with aging and cognition in 149 asymptomatic participants (38–71 years). Aging was associated with increased free water signal and reductions in myelin-sensitive R(1) and qMT indices but no apparent axon density differences in both precommissural and postcommissural fibers. Precommissural relative to postcommissural fibers showed a distinct microstructural pattern characterised by larger free water signal and axon orientation dispersion, with lower apparent myelin and axon density. Furthermore, differences in postcommissural microstructure were related to performance differences in object-location paired-associate learning. These results provide novel in vivo neuroimaging evidence for distinct microstructural properties of precommissural and postcommissural fibers that are consistent with their anatomy as found in axonal tracer studies, as well as for a contribution of postcommissural fibers to the learning of spatial configurations. SAGE Publications 2020-01-22 /pmc/articles/PMC7085915/ /pubmed/32219177 http://dx.doi.org/10.1177/2398212819899316 Text en © The Author(s) 2020 https://creativecommons.org/licenses/by/4.0/ This article is distributed under the terms of the Creative Commons Attribution 4.0 License (https://creativecommons.org/licenses/by/4.0/) which permits any use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access pages (https://us.sagepub.com/en-us/nam/open-access-at-sage). |
spellingShingle | Research Paper Coad, Bethany M. Craig, Emma Louch, Rebecca Aggleton, John P. Vann, Seralynne D. Metzler-Baddeley, Claudia Precommissural and postcommissural fornix microstructure in healthy aging and cognition |
title | Precommissural and postcommissural fornix microstructure in healthy aging and cognition |
title_full | Precommissural and postcommissural fornix microstructure in healthy aging and cognition |
title_fullStr | Precommissural and postcommissural fornix microstructure in healthy aging and cognition |
title_full_unstemmed | Precommissural and postcommissural fornix microstructure in healthy aging and cognition |
title_short | Precommissural and postcommissural fornix microstructure in healthy aging and cognition |
title_sort | precommissural and postcommissural fornix microstructure in healthy aging and cognition |
topic | Research Paper |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7085915/ https://www.ncbi.nlm.nih.gov/pubmed/32219177 http://dx.doi.org/10.1177/2398212819899316 |
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