Transcranial magnetic stimulation tracks subminute changes in cortical excitability during propofol anesthesia

Automated anesthesia systems that continuously monitor cortical excitability (CE) changes to govern drug infusion rates, are desirable. Paired‐pulse transcranial magnetic stimulation (ppTMS), with electromyography (EMG), provides noninvasive CE measures. We tested whether, and with what temporal res...

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Detalles Bibliográficos
Autores principales: Gersner, Roman, Paredes, Carmen, Hameed, Mustafa Q., Dhamne, Sameer C., Pascual‐Leone, Alvaro, Rotenberg, Alexander
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2020
Materias:
Brief Communications
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7085996/
https://www.ncbi.nlm.nih.gov/pubmed/32061019
http://dx.doi.org/10.1002/acn3.50981
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author Gersner, Roman
Paredes, Carmen
Hameed, Mustafa Q.
Dhamne, Sameer C.
Pascual‐Leone, Alvaro
Rotenberg, Alexander
author_facet Gersner, Roman
Paredes, Carmen
Hameed, Mustafa Q.
Dhamne, Sameer C.
Pascual‐Leone, Alvaro
Rotenberg, Alexander
author_sort Gersner, Roman
collection PubMed
description Automated anesthesia systems that continuously monitor cortical excitability (CE) changes to govern drug infusion rates, are desirable. Paired‐pulse transcranial magnetic stimulation (ppTMS), with electromyography (EMG), provides noninvasive CE measures. We tested whether, and with what temporal resolution, ppTMS‐EMG detects dose‐dependent CE in rats anesthetized with continuous intravenous propofol. Motor‐evoked potentials (MEPs) were recorded every 20 seconds as either propofol bolus or change in infusion rate was applied. ppTMS‐derived measures varied in direct proportion to propofol dose with subminute temporal resolution. We conclude that ppTMS‐EMG enables real‐time markers of target engagement by anesthetics that may be incorporated into an automated device.
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spelling pubmed-70859962020-03-24 Transcranial magnetic stimulation tracks subminute changes in cortical excitability during propofol anesthesia Gersner, Roman Paredes, Carmen Hameed, Mustafa Q. Dhamne, Sameer C. Pascual‐Leone, Alvaro Rotenberg, Alexander Ann Clin Transl Neurol Brief Communications Automated anesthesia systems that continuously monitor cortical excitability (CE) changes to govern drug infusion rates, are desirable. Paired‐pulse transcranial magnetic stimulation (ppTMS), with electromyography (EMG), provides noninvasive CE measures. We tested whether, and with what temporal resolution, ppTMS‐EMG detects dose‐dependent CE in rats anesthetized with continuous intravenous propofol. Motor‐evoked potentials (MEPs) were recorded every 20 seconds as either propofol bolus or change in infusion rate was applied. ppTMS‐derived measures varied in direct proportion to propofol dose with subminute temporal resolution. We conclude that ppTMS‐EMG enables real‐time markers of target engagement by anesthetics that may be incorporated into an automated device. John Wiley and Sons Inc. 2020-02-15 /pmc/articles/PMC7085996/ /pubmed/32061019 http://dx.doi.org/10.1002/acn3.50981 Text en © 2020 The Authors. Annals of Clinical and Translational Neurology published by Wiley Periodicals, Inc on behalf of American Neurological Association. This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
spellingShingle Brief Communications
Gersner, Roman
Paredes, Carmen
Hameed, Mustafa Q.
Dhamne, Sameer C.
Pascual‐Leone, Alvaro
Rotenberg, Alexander
Transcranial magnetic stimulation tracks subminute changes in cortical excitability during propofol anesthesia
title Transcranial magnetic stimulation tracks subminute changes in cortical excitability during propofol anesthesia
title_full Transcranial magnetic stimulation tracks subminute changes in cortical excitability during propofol anesthesia
title_fullStr Transcranial magnetic stimulation tracks subminute changes in cortical excitability during propofol anesthesia
title_full_unstemmed Transcranial magnetic stimulation tracks subminute changes in cortical excitability during propofol anesthesia
title_short Transcranial magnetic stimulation tracks subminute changes in cortical excitability during propofol anesthesia
title_sort transcranial magnetic stimulation tracks subminute changes in cortical excitability during propofol anesthesia
topic Brief Communications
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7085996/
https://www.ncbi.nlm.nih.gov/pubmed/32061019
http://dx.doi.org/10.1002/acn3.50981
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