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A Rare Case of Non-Small Cell Lung Cancer with BRAF V600E Gene: Case Report and Literature Review

Non-small cell lung cancer is one of the leading causes of mortality in the United States. The BRAF mutation, which has been associated with malignant melanoma, has been documented in only 3.5-5% of the non-small cell lung cancer (NSCLC) patient population.The involvement of the BRAF mutation in NSC...

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Autores principales: Patel, Dharti, Mubarik, Ateeq, Patel, Shilen, Vaziri, Ali, Muddassir, Salman
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cureus 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7086119/
https://www.ncbi.nlm.nih.gov/pubmed/32219049
http://dx.doi.org/10.7759/cureus.7055
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author Patel, Dharti
Mubarik, Ateeq
Patel, Shilen
Vaziri, Ali
Muddassir, Salman
author_facet Patel, Dharti
Mubarik, Ateeq
Patel, Shilen
Vaziri, Ali
Muddassir, Salman
author_sort Patel, Dharti
collection PubMed
description Non-small cell lung cancer is one of the leading causes of mortality in the United States. The BRAF mutation, which has been associated with malignant melanoma, has been documented in only 3.5-5% of the non-small cell lung cancer (NSCLC) patient population.The involvement of the BRAF mutation in NSCLC and the treatment for tumors with such mutations is still an evolving topic of interest, which is why more in depth information is warranted. We present a rare case of stage IV non-small cell lung adenocarcinoma, who presented first with a complicated pericardial effusion with evidence of malignant effusion. He had genetic testing done, revealing he had a positive BRAF V600E mutation. He was put on multiple chemotherapy regimens, but was most responsive to Vemurafenib. This case will shed light into the importance of the BRAF V600E gene and its importance in NSCLC for better prognosis value. 
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spelling pubmed-70861192020-03-26 A Rare Case of Non-Small Cell Lung Cancer with BRAF V600E Gene: Case Report and Literature Review Patel, Dharti Mubarik, Ateeq Patel, Shilen Vaziri, Ali Muddassir, Salman Cureus Genetics Non-small cell lung cancer is one of the leading causes of mortality in the United States. The BRAF mutation, which has been associated with malignant melanoma, has been documented in only 3.5-5% of the non-small cell lung cancer (NSCLC) patient population.The involvement of the BRAF mutation in NSCLC and the treatment for tumors with such mutations is still an evolving topic of interest, which is why more in depth information is warranted. We present a rare case of stage IV non-small cell lung adenocarcinoma, who presented first with a complicated pericardial effusion with evidence of malignant effusion. He had genetic testing done, revealing he had a positive BRAF V600E mutation. He was put on multiple chemotherapy regimens, but was most responsive to Vemurafenib. This case will shed light into the importance of the BRAF V600E gene and its importance in NSCLC for better prognosis value.  Cureus 2020-02-20 /pmc/articles/PMC7086119/ /pubmed/32219049 http://dx.doi.org/10.7759/cureus.7055 Text en Copyright © 2020, Patel et al. http://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Genetics
Patel, Dharti
Mubarik, Ateeq
Patel, Shilen
Vaziri, Ali
Muddassir, Salman
A Rare Case of Non-Small Cell Lung Cancer with BRAF V600E Gene: Case Report and Literature Review
title A Rare Case of Non-Small Cell Lung Cancer with BRAF V600E Gene: Case Report and Literature Review
title_full A Rare Case of Non-Small Cell Lung Cancer with BRAF V600E Gene: Case Report and Literature Review
title_fullStr A Rare Case of Non-Small Cell Lung Cancer with BRAF V600E Gene: Case Report and Literature Review
title_full_unstemmed A Rare Case of Non-Small Cell Lung Cancer with BRAF V600E Gene: Case Report and Literature Review
title_short A Rare Case of Non-Small Cell Lung Cancer with BRAF V600E Gene: Case Report and Literature Review
title_sort rare case of non-small cell lung cancer with braf v600e gene: case report and literature review
topic Genetics
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7086119/
https://www.ncbi.nlm.nih.gov/pubmed/32219049
http://dx.doi.org/10.7759/cureus.7055
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