Localized Inhibition of Protein Phosphatase 1 by NUAK1 Promotes Spliceosome Activity and Reveals a MYC-Sensitive Feedback Control of Transcription

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Deregulated expression of MYC induces a dependence on the NUAK1 kinase, but the molecular mechanisms underlying this dependence have not been fully clarified. Here, we show that NUAK1 is a predominantly nuclear protein that associates with a network of nuclear protein phosphatase 1 (PP1) interactors...

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Detalles Bibliográficos
Autores principales: Cossa, Giacomo, Roeschert, Isabelle, Prinz, Florian, Baluapuri, Apoorva, Silveira Vidal, Raphael, Schülein-Völk, Christina, Chang, Yun-Chien, Ade, Carsten Patrick, Mastrobuoni, Guido, Girard, Cyrille, Wortmann, Lars, Walz, Susanne, Lührmann, Reinhard, Kempa, Stefan, Kuster, Bernhard, Wolf, Elmar, Mumberg, Dominik, Eilers, Martin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cell Press 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7086158/
https://www.ncbi.nlm.nih.gov/pubmed/32006464
http://dx.doi.org/10.1016/j.molcel.2020.01.008

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