Drop Head Syndrome as a Rare Complication in Mixed Connective Tissue Disease

A 54-year-old woman developed drop head syndrome (DHS), Raynaud's phenomenon and creatine kinase (CK) elevation. She did not meet the international classification criteria of dermatomyositis/polymyositis, as we observed no muscle weakness, grasping pain or electromyography abnormality in her li...

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Detalles Bibliográficos
Autores principales: Akagi, Midori, Umeda, Masataka, Hashisako, Mikiko, Hara, Kazusato, Tsuji, Sousuke, Endo, Yushiro, Takatani, Ayuko, Shimizu, Toshimasa, Fukui, Shoichi, Koga, Tomohiro, Kawashiri, Shin-ya, Iwamoto, Naoki, Igawa, Takashi, Ichinose, Kunihiro, Tamai, Mami, Nakamura, Hideki, Origuchi, Tomoki, Niino, Daisuke, Kawakami, Atsushi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Japanese Society of Internal Medicine 2019
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7086316/
https://www.ncbi.nlm.nih.gov/pubmed/31735790
http://dx.doi.org/10.2169/internalmedicine.3626-19
Descripción
Sumario:A 54-year-old woman developed drop head syndrome (DHS), Raynaud's phenomenon and creatine kinase (CK) elevation. She did not meet the international classification criteria of dermatomyositis/polymyositis, as we observed no muscle weakness, grasping pain or electromyography abnormality in her limbs, and anti-aminoacyl tRNA synthetase (ARS) antibody was negative. Cervical magnetic resonance imaging and a muscle biopsy of the trapezius muscle revealed myositis findings as the only clinical observations in muscle. These findings, along with her anti-U1-ribonucleoprotein (RNP) antibody positivity and leukopenia, resulted in a diagnosis of mixed connective tissue disease (MCTD). Prednisolone treatment significantly improved her myositis. To our knowledge, this is the first report of DHS as the only muscle complication of MCTD.

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