Atypical Sarcoidosis Diagnosed by Massive Splenomegaly

We examined a 22-year-old woman who was admitted to our hospital with abdominal distention. At 19 years of age, the patient presented with hepatosplenomegaly. She was examined several times in another hospital; however, the cause was unidentified. Our evaluation showed severe pancytopenia and a sple...

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Detalles Bibliográficos
Autores principales: Saito, Satomi, Kodama, Kazuhisa, Kogiso, Tomomi, Yamanashi, Yuki, Taniai, Makiko, Ariizumi, Shunichi, Yamamoto, Masakazu, Tokushige, Katsutoshi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Japanese Society of Internal Medicine 2019
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7086327/
https://www.ncbi.nlm.nih.gov/pubmed/31666466
http://dx.doi.org/10.2169/internalmedicine.3646-19
Descripción
Sumario:We examined a 22-year-old woman who was admitted to our hospital with abdominal distention. At 19 years of age, the patient presented with hepatosplenomegaly. She was examined several times in another hospital; however, the cause was unidentified. Our evaluation showed severe pancytopenia and a spleen 13×24 cm in size. The serum levels of angiotensin-converting enzyme and lysozyme were elevated. She was diagnosed with liver sarcoidosis based on non-caseating epithelioid granuloma in liver biopsy tissue. To improve the symptoms, splenectomy was performed, and her pancytopenia and symptoms improved. Sarcoidosis should be considered in cases of massive splenomegaly.

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