Atypical Sarcoidosis Diagnosed by Massive Splenomegaly

We examined a 22-year-old woman who was admitted to our hospital with abdominal distention. At 19 years of age, the patient presented with hepatosplenomegaly. She was examined several times in another hospital; however, the cause was unidentified. Our evaluation showed severe pancytopenia and a sple...

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Autores principales: Saito, Satomi, Kodama, Kazuhisa, Kogiso, Tomomi, Yamanashi, Yuki, Taniai, Makiko, Ariizumi, Shunichi, Yamamoto, Masakazu, Tokushige, Katsutoshi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Japanese Society of Internal Medicine 2019
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7086327/
https://www.ncbi.nlm.nih.gov/pubmed/31666466
http://dx.doi.org/10.2169/internalmedicine.3646-19
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author Saito, Satomi
Kodama, Kazuhisa
Kogiso, Tomomi
Yamanashi, Yuki
Taniai, Makiko
Ariizumi, Shunichi
Yamamoto, Masakazu
Tokushige, Katsutoshi
author_facet Saito, Satomi
Kodama, Kazuhisa
Kogiso, Tomomi
Yamanashi, Yuki
Taniai, Makiko
Ariizumi, Shunichi
Yamamoto, Masakazu
Tokushige, Katsutoshi
author_sort Saito, Satomi
collection PubMed
description We examined a 22-year-old woman who was admitted to our hospital with abdominal distention. At 19 years of age, the patient presented with hepatosplenomegaly. She was examined several times in another hospital; however, the cause was unidentified. Our evaluation showed severe pancytopenia and a spleen 13×24 cm in size. The serum levels of angiotensin-converting enzyme and lysozyme were elevated. She was diagnosed with liver sarcoidosis based on non-caseating epithelioid granuloma in liver biopsy tissue. To improve the symptoms, splenectomy was performed, and her pancytopenia and symptoms improved. Sarcoidosis should be considered in cases of massive splenomegaly.
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spelling pubmed-70863272020-03-26 Atypical Sarcoidosis Diagnosed by Massive Splenomegaly Saito, Satomi Kodama, Kazuhisa Kogiso, Tomomi Yamanashi, Yuki Taniai, Makiko Ariizumi, Shunichi Yamamoto, Masakazu Tokushige, Katsutoshi Intern Med Case Report We examined a 22-year-old woman who was admitted to our hospital with abdominal distention. At 19 years of age, the patient presented with hepatosplenomegaly. She was examined several times in another hospital; however, the cause was unidentified. Our evaluation showed severe pancytopenia and a spleen 13×24 cm in size. The serum levels of angiotensin-converting enzyme and lysozyme were elevated. She was diagnosed with liver sarcoidosis based on non-caseating epithelioid granuloma in liver biopsy tissue. To improve the symptoms, splenectomy was performed, and her pancytopenia and symptoms improved. Sarcoidosis should be considered in cases of massive splenomegaly. The Japanese Society of Internal Medicine 2019-10-31 2020-03-01 /pmc/articles/PMC7086327/ /pubmed/31666466 http://dx.doi.org/10.2169/internalmedicine.3646-19 Text en Copyright © 2020 by The Japanese Society of Internal Medicine https://creativecommons.org/licenses/by-nc-nd/4.0/ The Internal Medicine is an Open Access journal distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License. To view the details of this license, please visit (https://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Case Report
Saito, Satomi
Kodama, Kazuhisa
Kogiso, Tomomi
Yamanashi, Yuki
Taniai, Makiko
Ariizumi, Shunichi
Yamamoto, Masakazu
Tokushige, Katsutoshi
Atypical Sarcoidosis Diagnosed by Massive Splenomegaly
title Atypical Sarcoidosis Diagnosed by Massive Splenomegaly
title_full Atypical Sarcoidosis Diagnosed by Massive Splenomegaly
title_fullStr Atypical Sarcoidosis Diagnosed by Massive Splenomegaly
title_full_unstemmed Atypical Sarcoidosis Diagnosed by Massive Splenomegaly
title_short Atypical Sarcoidosis Diagnosed by Massive Splenomegaly
title_sort atypical sarcoidosis diagnosed by massive splenomegaly
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7086327/
https://www.ncbi.nlm.nih.gov/pubmed/31666466
http://dx.doi.org/10.2169/internalmedicine.3646-19
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